What is Treximet: Uses, Warnings & Interactions

How to take Treximet

• Your doctor will tell you how much medicine to use. Do not use more than directed. Use only when you have a migraine. Do not use this medicine for regular headaches.

• Swallow the tablet whole. Do not break, crush, or chew it.

• Children 12 years of age or older: If your headache does not improve after the first dose, do not take a second dose. Call your doctor.

• Adults: If your headache does not improve after the first dose, wait at least 2 hours before you take a second dose. Do not take more than 2 tablets in 24 hours.

• This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

• Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

• This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

• Swallow the tablet whole. Do not break, crush, or chew it.

• Adults: If your headache does not improve after the first dose, wait at least 2 hours before you take a second dose. Do not take more than 2 tablets in 24 hours.

• Your doctor will tell you how much medicine to use. Do not use more than directed. Use only when you have a migraine. Do not use this medicine for regular headaches.

• Children 12 years of age or older: If your headache does not improve after the first dose, do not take a second dose. Call your doctor.

• Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

What to do if you miss a dose of Treximet

Treximet contraindications

• This medicine is not right for everyone. Do not use it if you had an allergic reaction (including asthma) to sumatriptan, naproxen, aspirin, or similar medicines, or if you have a history of heart disease, heart attack, angina, stroke, transient ischemic attack (TIA), ischemic bowel disease, peripheral vascular disease, or heart bypass surgery.

Treximet warnings

• Sudden or severe headache, problems with vision, speech, or walking

• Unexplained weight gain, swelling in your hands, ankles, or feet

• Unusual bleeding, bruising, or weakness

• Tell your doctor if you are pregnant or breastfeeding. Do not use this medicine during the later part of pregnancy, unless your doctor says it is okay.

• Tell your doctor if you have kidney disease, liver disease, anemia, asthma, bleeding problems, diabetes, fluid retention, high cholesterol, heart rhythm problems, high blood pressure, or a family history of heart disease. Tell your doctor if you have a history of seizures, ulcers, or stomach or bowel bleeding. Tell your doctor if you are on a low-salt diet or if you smoke or drink alcohol.

• This medicine may cause the following problems:Increased risk of blood clots, heart attack, heart rhythm problems, or strokeStomach ulcers or bleedingSerious drug reaction called serotonin syndrome (more likely when used with certain other medicines)Kidney or liver problemsSerious skin reactions

• Your headaches may become worse if you use a headache medicine for 10 or more days per month. Write down how often your headaches occur and how often you use this medicine.

• This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

• Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

• Keep all medicine out of the reach of children. Never share your medicine with anyone.

• Seizure

• Severe stomach pain, bloody or black stools

Treximet interactions

• Do not use this medicine if you have taken an MAO inhibitor in the past 14 days or another migraine medicine within the past 24 hours.

• Do not use other NSAIDs unless your doctor tells you it is okay. Some examples are aspirin, celecoxib, diclofenac, diflunisal, ibuprofen, or salsalate.

• Some medicines can affect how sumatriptan/naproxen works. Tell your doctor if you are using any of the following:Cyclosporine, digoxin, lithium, methotrexate, pemetrexed, or probenecidBlood pressure medicineBlood thinner (including warfarin)Diuretic (water pill)Medicine to treat depressionSteroid (including dexamethasone, hydrocortisone, methylprednisolone, prednisolone, prednisone)

• Your headaches may become worse if you use a headache medicine for 10 or more days per month. Write down how often your headaches occur and how often you use this medicine.

• This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

• Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

• Keep all medicine out of the reach of children. Never share your medicine with anyone.