What is Trifluoperazine: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Trifluoperazine overview

BRAND NAMES:

Generic Names:

  • Trifluoperazine Hcl

Uses:

  • Treats psychotic disorders and anxiety. Sometimes given for nausea and vomiting caused by chemotherapy. Belongs to a class of drugs called phenothiazines.

Therapeutic Classes:

  • Antipsychotic

Forms:

  • Tablet, Capsule, Liquid

How it’s taken:

  • By mouth

What is Trifluoperazine used for?

What form(s) does Trifluoperazine come in

  • Tablet

  • Capsule

  • Liquid

What are common Trifluoperazine doses?

  • Tablet 1MG

  • Tablet 2MG

  • Tablet 5MG

  • Tablet 10MG

Common Trifluoperazine prescriptions

  • Trifluoperazine HCl
    10mg tablet

  • Trifluoperazine HCl
    1mg tablet

  • Trifluoperazine HCl
    2mg tablet

  • Trifluoperazine HCl
    5mg tablet

How to take Trifluoperazine

  • Your doctor will tell you how much medicine to take and how often.

  • Take with food to avoid stomach upset.

  • Measure the oral liquid using the marked dropper that comes with the medicine. Mix with a full glass of water, milk, juice, or soda pop. Drink the medicine right away. Avoid getting this medicine on your skin.

  • Your doctor will tell you how much medicine to take and how often.

  • Take with food to avoid stomach upset.

  • Measure the oral liquid using the marked dropper that comes with the medicine. Mix with a full glass of water, milk, juice, or soda pop. Drink the medicine right away. Avoid getting this medicine on your skin.

What to do if you miss a dose of Trifluoperazine

  • Take the missed dose as soon as possible.

  • If it is almost time for your next regular dose, wait until then to take your medicine and skip the missed dose.

  • You should not use two doses at the same time.

Trifluoperazine contraindications

  • You should not use this medicine if you have ever had an allergic reaction to trifluoperazine or to any other phenothiazines, such as Mellaril®, Prolixin®, Thorazine®, or Trilafon®.

Trifluoperazine warnings

  • If you are pregnant or breastfeeding, talk to your doctor before taking this medicine.

  • Let your doctor know if you have a history of breast cancer, epilepsy, glaucoma, prostate problems, lung, heart, kidney or liver disease, or Parkinson's disease.

  • Trifluoperazine may make you dizzy and drowsy. If it does, avoid driving a car or operating machinery.

  • Get up slowly from a lying or sitting position to avoid dizziness from this medicine.

  • This medicine may make your skin more sensitive to the sun. Try not to spend long periods in direct sunlight and protect your skin from the sun.

  • While taking this medicine, you might become more sensitive to hot and cold temperatures. Dress warmly in cold weather and don't stay outside too long. Avoid becoming overheated during hot weather.

  • There is a risk side effects that include muscle spasms, twitching in the face and body, and uncontrolled tongue or jaw movement. Talk to your doctor about this risk.

  • Do not stop taking this medicine suddenly without first talking to your doctor. You may need to take smaller and smaller doses before completely stopping.

Trifluoperazine interactions

  • Do not drink alcohol while taking this medicine.

  • Make sure your doctor knows if you are taking other drugs that can make you sleepy such as narcotic pain killers, sleeping pills, sedatives, or cold or allergy medicine.

  • Trifluoperazine may make you dizzy and drowsy. If it does, avoid driving a car or operating machinery.

  • Get up slowly from a lying or sitting position to avoid dizziness from this medicine.

  • This medicine may make your skin more sensitive to the sun. Try not to spend long periods in direct sunlight and protect your skin from the sun.

  • While taking this medicine, you might become more sensitive to hot and cold temperatures. Dress warmly in cold weather and don't stay outside too long. Avoid becoming overheated during hot weather.

  • There is a risk side effects that include muscle spasms, twitching in the face and body, and uncontrolled tongue or jaw movement. Talk to your doctor about this risk.

  • Do not stop taking this medicine suddenly without first talking to your doctor. You may need to take smaller and smaller doses before completely stopping.

Trifluoperazine side effects

Serious Side Effects

  • Skin rash

  • Sore throat or fever

  • Rapid breathing or heartbeat

  • Severe stiffness

  • Convulsions

  • Spasms of neck, face or back

  • Muscle twitching or jerking

  • Sensitivity to sunlight

Less Serious Side Effects

  • Loss of appetite

  • Sensitivity to sunlight

  • Dry mouth

  • Drowsiness or dizziness

  • Loss of interest in sex or loss of ability to have sex

  • Nausea

  • Blurred vision

  • Agitation or restlessness

Subscribe to our savings newsletter

Health education, drug info, wellness & more

By clicking 'Subscribe', I agree to SingleCare's Terms & Conditions.