What is Tybost? Uses, warnings & side effects

Updated May 14, 2025  •  Published Dec 30, 2020

Tybost overview

BRAND NAMES:

  • Tybost

Generic Names:

  • Tybost

Uses:

  • Increases the effects of atazanavir or darunavir to help treat HIV infection. This medicine does not cure HIV or AIDS, but it may help slow the progress of the disease.

Therapeutic Classes:

  • Anti-Infective Agent, Antiviral

Forms:

  • Tablet

How it’s taken:

  • By mouth

What is Tybost used for?

Tybost is a prescription medicine used to help treat adults with the Human Immunodeficiency Virus-1 (HIV-1). It works by boosting the levels of protease inhibitors, darunavir or atazanavir.

What form(s) does Tybost come in?

  • Tablet

What are common Tybost dosages?

  • Bottle 30 Tablets

Tybost images - What does Tybost look like?

  • Tybost
    30 tablets bottle

How to take Tybost

  • Your doctor will tell you how much medicine to use. Do not use more than directed. Take all other medicines your doctor has prescribed as part of your combination treatment. You need to take cobicistat at the same time you take atazanavir or darunavir.

  • Do not stop using this medicine without checking first with your doctor. If you stop the medicine even for a short time, the virus may become harder to treat. Contact your doctor or pharmacist when your supply is running low so you do not run out.

  • Oral routeIt is best to take this medicine with food or milk.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep the medicine in the original bottle. Keep it tightly closed. Do not use this medicine if the seal on the bottle is broken or missing.

  • Do not stop using this medicine without checking first with your doctor. If you stop the medicine even for a short time, the virus may become harder to treat. Contact your doctor or pharmacist when your supply is running low so you do not run out.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Your doctor will tell you how much medicine to use. Do not use more than directed. Take all other medicines your doctor has prescribed as part of your combination treatment. You need to take cobicistat at the same time you take atazanavir or darunavir.

  • Oral routeIt is best to take this medicine with food or milk.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep the medicine in the original bottle. Keep it tightly closed. Do not use this medicine if the seal on the bottle is broken or missing.

What to do if you miss a dose of Tybost

Tybost contraindications - Who shouldn't take Tybost?

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to cobicistat.

Tybost warnings

  • This medicine may cause kidney problems, including Fanconi syndrome, when used together with tenofovir.

  • Tell your doctor if you have kidney disease or liver disease.

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant. Certain birth control pills may not work as well to prevent pregnancy when used with this medicine. Use another form of birth control (including condoms or spermicide) along with your pills.

  • Do not breastfeed. You can spread HIV or AIDS to your baby through your breast milk.

  • This medicine will not keep you from giving HIV to others. Always practice safe sex, even if your partner also has HIV. Do not share needles or other items that may have blood or body fluids on them.

  • Your immune system may get stronger when you start using HIV medicines. This could cause a hidden infection in your body to become active. Tell your doctor right away if you notice any changes in your health.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Tybost interactions & what to avoid when taking Tybost

  • This medicine will not keep you from giving HIV to others. Always practice safe sex, even if your partner also has HIV. Do not share needles or other items that may have blood or body fluids on them.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Take antacids at least 2 hours before or after you take this medicine.

  • Do not use this medicine together with alfuzosin, carbamazepine, cisapride, colchicine, dihydroergotamine, drospirenone/ethinyl estradiol, ergotamine, dronedarone, indinavir, irinotecan, lomitapide, lovastatin, lurasidone, methylergonovine, nevirapine, oral midazolam, phenobarbital, phenytoin, pimozide, ranolazine, rifampin, sildenafil for pulmonary hypertension, simvastatin, St John's wort, and triazolam.

  • There are many other drugs that can interact with this medicine. Make sure your doctor knows about all other medicines you are using, especially any of the following:Atorvastatin, boceprevir, bosentan, buprenorphine, buprenorphine/naloxone, clonazepam, colchicine, cyclosporine, dasatinib, efavirenz, eslicarbazepine, etravirine, everolimus, famotidine, fentanyl, maraviroc, methadone, nevirapine, nilotinib, omeprazole, oxcarbazepine, rifabutin, rosuvastatin, salmeterol, simeprevir, sirolimus, tacrolimus, tramadol, vinblastine, vincristineBirth control pillsBlood pressure medicineBlood thinner (including rivaroxaban, warfarin)Medicine for depression or mental health problemsMedicine for heart rhythm problemsMedicine to treat an infection (including clarithromycin, erythromycin, itraconazole, ketoconazole, telithromycin, voriconazole)Steroid medicine (including beclomethasone, dexamethasone, prednisolone)

Tybost side effects - How does Tybost make you feel?

Serious Side Effects

  • Decrease in how much or how often you urinate, blood in your urine, lower back or side pain

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

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