What is Vitamin K1: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Vitamin K1 overview

BRAND NAMES:

  • Vitamin K1 Novaplus, Novaplus vitamin K1

Generic Names:

  • Vitamin K1

Uses:

  • Prevents bleeding problems by helping blood clot better. Also treats or prevents bleeding problems in newborn infants.

Therapeutic Classes:

  • Antidote, Nutritive Agent

Forms:

  • Injectable

How it’s taken:

  • By injection

What is Vitamin K1 used for?

Phytonadione is a form of vitamin K made by man. It works to enhance the low level of vitamin K in your body. Phytonadione is also used to treat certain bleeding or blood-clotting problems.

What form(s) does Vitamin K1 come in

  • Injectable

What are common Vitamin K1 doses?

  • Ampule 0.5ML of 1MG/0.5ML

  • Ampule 1ML of 10MG/ML

  • Bottle 25GM of

Common Vitamin K1 prescriptions

  • Vitamin K1
    0.5ml of 1mg/0.5ml ampule

  • Vitamin K1
    1ml of 10mg/ml ampule

How to take Vitamin K1

  • Injection routeYour doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot under your skin, into a muscle, or into a vein.

  • Injection routeA nurse or other health provider will give you this medicine.

  • Injection routeYou may be taught how to give your medicine at home. Make sure you understand all instructions before giving yourself an injection. Do not use more medicine or use it more often than your doctor tells you to.

  • Check the medicine before using. It should be clear and yellow. Do not use it if it is discolored or has particles in it.

  • Injection routeYou will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas.

  • Injection routeUse a new needle and syringe each time you inject your medicine.

  • Your doctor may also give you plasma or other blood products in addition to vitamin K if your bleeding is severe.

  • Injection routeThrow away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.

  • Missed dose: Injection routeCall your doctor or pharmacist for instructions.

  • Injection routeIf you store this medicine at home, keep it at room temperature, away from heat and direct light.

  • Injection routeA nurse or other health provider will give you this medicine.

  • Injection routeYou may be taught how to give your medicine at home. Make sure you understand all instructions before giving yourself an injection. Do not use more medicine or use it more often than your doctor tells you to.

  • Injection routeUse a new needle and syringe each time you inject your medicine.

  • Injection routeThrow away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.

  • Check the medicine before using. It should be clear and yellow. Do not use it if it is discolored or has particles in it.

  • Injection routeYour doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot under your skin, into a muscle, or into a vein.

  • Your doctor may also give you plasma or other blood products in addition to vitamin K if your bleeding is severe.

  • Injection routeIf you store this medicine at home, keep it at room temperature, away from heat and direct light.

  • Injection routeYou will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas.

  • Missed dose: Injection routeCall your doctor or pharmacist for instructions.

What to do if you miss a dose of Vitamin K1

Vitamin K1 contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to phytonadione or vitamin K.

Vitamin K1 warnings

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Tell your doctor if you are pregnant or breastfeeding, or if you have liver disease, kidney disease, or if you have a problem with blood clotting too much (which can lead to a stroke).

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Vitamin K1 interactions

  • Some medicines can affect how this medicine works. Tell your doctor if you are using a blood thinner, including warfarin.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • You might also be given plasma or other blood products in addition to vitamin K.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Vitamin K1 side effects

Serious Side Effects

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Chest pain, sudden headache, trouble breathing, pain in your leg

  • Lightheadedness, dizziness, fainting

  • Rash

Less Serious Side Effects

  • Warmth or redness in your face, neck, arms, or upper chest

  • Change in sense of taste

  • Redness, pain, swelling, or a hard lump where the injection was given

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