What is Vosevi: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 31, 2020

Vosevi overview

BRAND NAMES:

  • Vosevi

Generic Names:

  • Vosevi

Uses:

  • Treats chronic hepatitis C infection.

Therapeutic Classes:

  • Antiviral

Forms:

  • Tablet

How it’s taken:

  • By mouth

What is Vosevi used for?

What form(s) does Vosevi come in

  • Tablet

What are common Vosevi doses?

  • Bottle 28 Tablets

Common Vosevi prescriptions

  • Vosevi
    28 tablets bottle

How to take Vosevi

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Take all of the medicine in your prescription to clear up your infection, even if you feel better after the first few doses.

  • Oral routeIt is best to take this medicine with food or milk.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep this medicine in its original container.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Take all of the medicine in your prescription to clear up your infection, even if you feel better after the first few doses.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep this medicine in its original container.

  • Oral routeIt is best to take this medicine with food or milk.

What to do if you miss a dose of Vosevi

Vosevi contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to sofosbuvir, velpatasvir, or voxilaprevir.

Vosevi warnings

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • This medicine may cause the following problems:Increased risk of reactivation of hepatitis BWorsening of liver problemsSlow and uneven heartbeat when taken with amiodarone

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, other liver disease (including hepatitis B), or heart disease.

Vosevi interactions

  • Take this medicine 4 hours before or after you take antacids containing aluminum or magnesium.

  • Amiodarone can cause serious side effects if used together with sofosbuvir or if you have used it recently.

  • Some medicines can affect how sofosbuvir/velpatasvir/voxilaprevir works. Tell your doctor if you are using any of the following:Cyclosporine, dabigatran, digoxin, imatinib, irinotecan, lapatinib, methotrexate, mitoxantrone, rifabutin, rifapentine, St John€™s wort, sulfasalazine, topotecanMedicine to lower cholesterol (including atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, simvastatin)Medicine to treat HIV infection (including atazanavir, efavirenz, lopinavir, tenofovir, tipranavir/ritonavir)Medicine to treat seizures (including carbamazepine, oxcarbazepine, phenobarbital, phenytoin)

  • Do not use this medicine together with rifampin.

Vosevi side effects

Serious Side Effects

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Dark urine, pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes

  • Fainting, dizziness, lightheadedness

  • Slow or uneven heartbeat

Less Serious Side Effects

  • Tiredness or weakness, trouble sleeping

  • Diarrhea

  • Headache

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