What is Votrient: Uses, Warnings & Interactions

How to take Votrient

• Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

• Oral routeIt is best to take this medicine on an empty stomach. Take this medicine at least 1 hour before or 2 hours after a meal.

• Swallow the tablet whole. Do not crush, break, or chew it.

• This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

• Missed dose: If you miss a dose or forget to take your medicine and it is less than 12 hours until your next dose, skip that dose and take your next dose at the normal time. Do not use extra medicine to make up for a missed dose.

• Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

• Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

• Oral routeIt is best to take this medicine on an empty stomach. Take this medicine at least 1 hour before or 2 hours after a meal.

• Missed dose: If you miss a dose or forget to take your medicine and it is less than 12 hours until your next dose, skip that dose and take your next dose at the normal time. Do not use extra medicine to make up for a missed dose.

• Swallow the tablet whole. Do not crush, break, or chew it.

• Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

• This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

• Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

• Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

What to do if you miss a dose of Votrient

Votrient contraindications

• This medicine is not right for everyone. Do not use it if you had an allergic reaction to pazopanib, or if you are pregnant.

Votrient warnings

• Keep all medicine out of the reach of children. Never share your medicine with anyone.

• Injection routeThis medicine may cause birth defects if either partner is using it during conception or pregnancy. Tell your doctor right away if you or your partner becomes pregnant. Men and women should use an effective form of birth control to keep from getting pregnant during treatment with this medicine and for at least 2 weeks after your last dose.

• Do not breastfeed while you are using this medicine and for 2 weeks after the last dose.

• Tell your doctor if you have kidney disease, liver disease (including Gilbert syndrome), heart disease, high blood pressure, lung disease, stomach or bowel problems, thyroid problems, or a history of heart rhythm problems (including QT prolongation), heart attack, or stroke. Tell your doctor if you had any bleeding problems in the last 6 months, including stomach or bowel bleeding.

• This medicine may cause the following problems:Severe liver problemsChanges in heart rhythm, including QT prolongation, Torsades de pointesHeart failure, high blood pressure, heart attack, or strokeBleeding problemsIncreased risk of blood clotsInterstitial lung disease or pneumonitis, which may be life-threateningStomach or bowel problems (including perforation, fistula)Reversible posterior leukoencephalopathy syndrome (RPLS)High blood pressureHypothyroidism (underactive thyroid)Kidney problemsTumor lysis syndromeSerious infections

• This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.

• Oral routeMedicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

• Tell any doctor who treats you that you are using this medicine. This medicine may affect the way your body heals from cuts and wounds. You may need to stop using it at least 7 days before you have surgery.

• Cancer medicines can cause diarrhea, nausea, or vomiting in most people, sometimes even after they receive medicine to prevent it.

• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Votrient interactions

• Some foods and medicines can affect how pazopanib works. Tell your doctor if you are using any of the following:Bevacizumab, clarithromycin, ketoconazole, lapatinib, pemetrexed, rifampin, ritonavir, simvastatin, topotecanMedicine for heart rhythm problemsStomach medicine (including esomeprazole)

• Take antacids several hours before or after you take pazopanib.

• Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

• Tell any doctor who treats you that you are using this medicine. This medicine may affect the way your body heals from cuts and wounds. You may need to stop using it at least 7 days before you have surgery.

• Cancer medicines can cause diarrhea, nausea, or vomiting in most people, sometimes even after they receive medicine to prevent it.

• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments. You will need to have your blood pressure measured before you start this medicine and while you are using it.

• Keep all medicine out of the reach of children. Never share your medicine with anyone.