Can I take gabapentin with ibuprofen?

Q: Can I take gabapentin with ibuprofen?

Yes, you can take gabapentin with ibuprofen safely. There are no known drug interactions between the two because they belong to different drug classes and work through different mechanisms. This combination may provide better pain relief for some people, though each medication has its own potential side effects that should be monitored.

Medically reviewed by Josephine Bawab, Pharm.D.

Licensed Pharmacist

Updated Jan 9, 2026 • Published Jan 9, 2026

Fact Checked

Yes, you can take gabapentin with ibuprofen safely. There are no known drug interactions between the two because they belong to different drug classes and work through different mechanisms. This combination may provide better pain relief for some people, though each medication has its own potential side effects that should be monitored.

Want to learn more about gabapentin and ibuprofen? Here’s our full article: Can you take ibuprofen with gabapentin?

See more drug comparison resources below:

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Medically reviewed by Josephine Bawab, Pharm.D.

Licensed Pharmacist

Josephine Bawab, Pharm.D., graduated from Virginia Commonwealth University School of Pharmacy. She began working in community pharmacy in 2012 and has worked for multiple chain pharmacies since then. She is passionate about helping patients and precepting students. She currently works and resides in Virginia, where she is just a few minutes away from the beach.

Can I take gabapentin with ibuprofen?

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