Is there a Trulicity generic?

In this article:

• Is there a generic for Trulicity?
• How much is Trulicity?
• Is Trulicity covered by insurance?
• Generic alternatives to Trulicity

In this article

• Is there a generic for Trulicity?
• How much is Trulicity?
• Is Trulicity covered by insurance?
• Generic alternatives to Trulicity

Trulicity (dulaglutide) is a brand-name drug FDA-approved to lower blood sugar levels and reduce the risk of heart disease complications like heart attack or stroke in people with Type 2 diabetes and known heart disease or multiple risk factors. It may sometimes be prescribed off-label for weight loss. As is the case with many Type 2 diabetes treatments, Trulicity is intended to be taken in addition to lifestyle changes such as diet and exercise.

Like many brand-name prescriptions, Trulicity can be expensive. Unfortunately, there is no generic version in the United States. Here’s everything you need to know about generic Trulicity, the cost of brand-name Trulicity, and lower-cost alternatives to this weekly Type 2 diabetes injection.

Is there a generic for Trulicity?

There is no generic for Trulicity. Technically, there never will be a generic version because Trulicity is a biologic drug, according to Tiffany Marie Hendricks, MD, DipABFM, DipABLM, a double board-certified lifestyle and family medicine physician and metabolic health consultant. 

Biologic drugs are made from living organisms, so they can’t be exactly replicated. While a generic drug contains exactly the same active ingredient as its brand-name counterpart, a biosimilar drug is what the Food & Drug Administration (FDA) calls “highly similar” to the original prescription drug. Clinical trials should also prove that the biosimilar drug has the same risks, benefits, safety, and effectiveness as the original brand-name medication.

So, when can you expect a lower-cost biosimilar version of Trulicity? No sooner than 2027. That’s when Eli Lilly’s US patent for Trulicity expires, according to Dr. Hendricks.

How much is Trulicity?

Without insurance or other discounts, the average retail price for Trulicity is about $1,400 for 4, 1.5 mg/0.5 ml 0.5 ml pens. This comprises a 28-day supply since the drug is administered as a subcutaneous injection once per week. At retail price, once-weekly injections of Trulicity can add up to more than $18,000 annually.

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Is Trulicity covered by insurance?

“In my experience, Trulicity is covered by many of the common insurances,” says Laura Sychta, DNP, FNP-BC, DipACLM, a board-certified primary care nurse practitioner in Oakland County, Michigan. 

However, both Sychta and Dr. Hendricks say most health plans require prior authorization. Some insurance policies may also require step therapy, meaning that you will be required to try lower-cost alternatives before receiving coverage for Trulicity. Finally, drugs are usually only covered by insurance when taken for their FDA-approved purpose — in this case, blood sugar regulation (glycemic control) or cardiovascular protection in the setting of Type 2 diabetes.

Generic alternatives to Trulicity

In most cases, generic drugs cost less than brand-name drugs. There is no generic Trulicity, but Trulicity belongs to a class of drugs called glucagon-like peptide-1 receptor agonists (GLP-1 receptor agonists). And as of 2025, there are two generic GLP-1s: liraglutide (generic for Victoza) and exenatide (generic for Byetta).

• Liraglutide. If you need to use a more affordable GLP-1 than Trulicity, Dr. Hendricks says this injectable is the number-one choice. “It’s taken once daily instead of weekly, but it usually costs less and works in the same way,” she explains. 
• Exenatide. Like its brand-name counterpart, Byetta, exenatide is a twice-daily injection used to lower blood sugar in adults with Type 2 diabetes. 

In most cases, a pharmacist can dispense generic liraglutide or exenatide even if your prescription is for brand-name Victoza or Byetta. However, pharmacy laws on generic substitution may vary by state.

Dr. Hendricks also suggests asking for additional information from your healthcare provider about these Trulicity alternatives:

• Other GLP-1 agonists. Ozempic (semaglutide) is another brand-name weekly injection approved to lower blood sugar in Type 2 diabetes patients. Though Ozempic also has a very high retail price, it may be a more affordable option if your insurance policy covers Ozempic instead of Trulicity.
• Older generic diabetes medications. “Metformin, pioglitazone, and sulfonylureas are much cheaper, though they work differently and have different side effects,” Dr. Hendricks says.

Because none of these drugs is an exact copy of Trulicity, the active ingredients, benefits, potential risks (allergic reaction or side effects), known interactions, and clinical study data may vary. Never switch diabetes medications without seeking personalized medical advice from a prescriber who knows your medical history, health conditions, and other medications. 

Finally, if you are struggling to afford or access your Trulicity prescription, tell your healthcare provider. While there are no known cases of Trulicity withdrawal, suddenly stopping an antidiabetic medication may result in dangerously high blood sugar. In addition to keeping in contact with your prescriber about medications, you can ask for advice on lifestyle changes that can help you maintain healthier blood sugar levels.