Drug vs. Drug

Xtampza vs Oxycontin: Main Differences and Similarities

SingleCare Logo for author page By | June 26, 2019

Xtampza ER and Oxycontin are two extended-release formulations of the opioid analgesic, oxycodone. They both deliver effective pain relief with a lower risk of abuse and dependence. While Xtampza is a newer version of extended-release oxycodone, they both work in identical ways to treat similar types of pain. Read on to learn more about their differences.

Xtampza ER

Xtampza ER is formulated as an oral capsule containing microspheres of oxycodone and other inactive ingredients. This unique formulation decreases abuse and dependence because crushing the capsules has no effect on the delivery of drug in the body. In other words, Xtampza will not produce greater feelings of euphoria if crushed and snorted. The extended-release effect of Xtampza is also not changed by crushing the capsules.

Xtampza is available as a 9 mg, 13.5 mg, 18 mg, 27 mg, or 36 mg oral capsule.

Oxycontin

Oxycontin is formulated as an extended-release oral tablet. Compared to other formulations, crushing the tablets can impair the delivery of the drug in the body. When crushed, oxycodone may be rapidly released and absorbed. The extended-release effect of the drug is thus, greatly affected. Oxycontin remains a commonly abused opioid according to the DEA.

Oxycontin is available as a 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, 60 mg, and 80 mg oral tablet.

Xtampza vs Oxycontin Side by Side Comparison

Xtampza ER and Oxycontin are two opioid medications that can treat pain. Their differences and similarities can be found in the table below. Because they contain the same active ingredient, their side effects and interactions are identical.

Xtampza ER Oxycontin
Prescribed For
  • Moderate to severe pain
  • Moderate to severe pain
Drug Classification
  • Opioid
  • Opioid
Manufacturer
Common Side Effects
  • Constipation
  • Drowsiness
  • Dizziness
  • Headache
  • Nausea
  • Vomiting
  • Pruritus
  • Lethargy
  • Anxiety
  • Fatigue
  • Flushing
  • Constipation
  • Drowsiness
  • Dizziness
  • Headache
  • Nausea
  • Vomiting
  • Pruritus
  • Lethargy
  • Anxiety
  • Fatigue
  • Flushing
Is there a generic?
  • There is no generic currently available
  • There is no generic currently available
Is it covered by insurance?
  • Varies according to your provider
  • Varies according to your provider
Dosage Forms
  • Oral capsule, extended release
  • Oral capsule, extended release
Average Cash Price
  • $460 for a supply of 60, 18 mg capsules
  • $260 for a supply of 60, 10 mg extended-release tablets
SingleCare Discount Price
Drug Interactions
  • Alcohol
  • SSRI/SNRI antidepressants
  • Triptans
  • CNS depressants (opioids, antihistamines, antipsychotics, antianxiety agents, hypnotics, antiemetics, phenothiazines, tranquilizers)
  • Mixed agonist/antagonist analgesics (butorphanol, nalbuphine, pentazocine, buprenorphine)
  • Anticholinergics
  • MAO inhibitors
  • Tricyclic antidepressants
  • CYP3A4 and CYP2D6 inhibitors (macrolide antibiotics, azole-antifungal agents, protease inhibitors)
  • CYP3A4 inducers (rifampin, carbamazepine, phenytoin)
  • Muscle relaxants
  • Diuretics
  • Alcohol
  • SSRI/SNRI antidepressants
  • Triptans
  • CNS depressants (opioids, antihistamines, antipsychotics, antianxiety agents, hypnotics, antiemetics, phenothiazines, tranquilizers)
  • Mixed agonist/antagonist analgesics (butorphanol, nalbuphine, pentazocine, buprenorphine)
  • Anticholinergics
  • MAO inhibitors
  • Tricyclic antidepressants
  • CYP3A4 and CYP2D6 inhibitors (macrolide antibiotics, azole-antifungal agents, protease inhibitors)
  • CYP3A4 inducers (rifampin, carbamazepine, phenytoin)
  • Muscle relaxants
  • Diuretics
Can I use while planning pregnancy, pregnant, or breastfeeding?
  • Oxycodone is in Pregnancy Category B. It may not harm an unborn baby but may cause withdrawal symptoms. Consult a doctor regarding steps to take while pregnant or breastfeeding.
  • Oxycodone is in Pregnancy Category B. It may not harm an unborn baby but may cause withdrawal symptoms. Consult a doctor regarding steps to take while pregnant or breastfeeding.

Summary

Xtampza ER and Oxycontin are two opioid medications for severe pain that does not respond to other therapies. Both medications contain extended-release formulations of oxycodone. However, Xtampza ER is an oral capsule while Oxycontin is an oral tablet.

Xtampza ER is a newer formulation that contains microspheres which are not affected by crushing the drug. This abuse-deterrent formulation makes it difficult to achieve the “high” that many drug abusers seek. On the other hand, Oxycontin may deliver oxycodone at a faster rate when crushed.

Both medications are often taken every 12 hours for pain depending on a doctor’s instructions. Xtampza ER and Oxycontin are Schedule II drugs that have a high potential for abuse and dependence. Therefore, these drugs should only be used under the supervision of a doctor.