What is Abiraterone: Uses, Warnings & Interactions

Updated May 6, 2025  •  Published Dec 30, 2020

Abiraterone overview

BRAND NAMES:

  • Zytiga, Yonsa

Generic Names:

  • Abiraterone Acetate

Uses:

  • Treats prostate cancer. This medicine is given with prednisone.

Therapeutic Classes:

  • Antiandrogen

Forms:

  • Tablet

How it’s taken:

  • By mouth

What is Abiraterone used for?

What form(s) does Abiraterone come in

  • Tablet

What are common Abiraterone doses?

  • Tablet 250MG

Common Abiraterone prescriptions

  • Abiraterone Acetate
    250mg tablet

  • Abiraterone Acetate
    500mg tablet

How to take Abiraterone

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Take this medicine on an empty stomach, 1 hour before or 2 hours after a meal.

  • Swallow the tablet whole with water. Do not break, crush, or chew it.

  • Your doctor may also give you other medicines (including gonadotropin-releasing hormone medicine) during treatment with abiraterone or you should have had surgical removal of the testes before using this medicine.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Missed dose: If you missed a dose, skip that dose and take your normal dose the following day. If you miss more than one dose, call your doctor right away.

  • Swallow the tablet whole with water. Do not break, crush, or chew it.

  • Missed dose: If you missed a dose, skip that dose and take your normal dose the following day. If you miss more than one dose, call your doctor right away.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Take this medicine on an empty stomach, 1 hour before or 2 hours after a meal.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Your doctor may also give you other medicines (including gonadotropin-releasing hormone medicine) during treatment with abiraterone or you should have had surgical removal of the testes before using this medicine.

What to do if you miss a dose of Abiraterone

Abiraterone contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to abiraterone.

Abiraterone warnings

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Women who are pregnant or may become pregnant should not touch this medicine without wearing gloves.

  • This medicine may cause birth defects if a man is using it when his partner becomes pregnant. Use a condom plus another form of birth control during treatment with this medicine and for 3 weeks after the last dose. Tell your doctor right away if a pregnancy occurs while you are using this medicine.

  • Tell your doctor if you have liver disease, heart or blood vessel disease, high blood pressure, heart failure, heart rhythm problems, a recent heart attack, diabetes, electrolyte imbalance, or a history of adrenal problems.

  • This medicine may cause the following problems:High blood pressureAdrenal problemsLiver problemsIncreased risk of bone fractures and death when used together with radium 223 dichloride (radiation treatment)Low blood sugar

  • Do not stop using this medicine, even for a short time, without first asking your doctor.

  • Talk with your doctor before using this medicine if you plan to have children. Some men who use this medicine have become infertile (unable to have children).

Abiraterone interactions

  • Some medicines can affect how abiraterone works. Tell your doctor if you are using carbamazepine, dextromethorphan, phenobarbital, phenytoin, pioglitazone, rifabutin, rifampin, rifapentine, or thioridazine.

  • This medicine may cause birth defects if a man is using it when his partner becomes pregnant. Use a condom plus another form of birth control during treatment and for 1 week after the last dose. Tell your doctor right away if a pregnancy occurs while you are taking this medicine.

  • Tell your doctor if you have liver disease, a history of adrenal problems, high blood pressure, heart failure, heart rhythm problems, or recently had a heart attack.

  • This medicine may cause the following problems:High blood pressureLow potassium levelsAdrenal problemsLiver problems

  • Do not stop using this medicine even for a short time without asking your doctor.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments. You will need to have your blood pressure measured before you begin to take this medicine and while you are taking it.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Abiraterone side effects

Serious Side Effects

  • Fast, slow, pounding, or uneven heartbeat

  • Fever, chills, cough, runny or stuffy nose, sore throat, body aches

  • Rapid weight gain, swelling in your hands, ankles, or feet

  • Shaking, trembling, sweating, faintness or lightheadedness, hunger, confusion

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Bone pain, pain or swelling in the arms or legs without any injury

  • Dark freckles, skin color changes, feeling of coldness, weakness, tiredness, weight loss

  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes

  • Dry mouth, increased thirst, muscle cramps

Less Serious Side Effects

  • Diarrhea, upset stomach

  • Joint or muscle pain, weakness, or swelling

  • Headache

  • Warmth or redness in your face, neck, arms, or upper chest

  • Falls, bruise

  • Warmth or redness in your face, neck, arms, or upper chest