What is Aklief: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published May 28, 2022

Aklief overview

BRAND NAMES:

  • Aklief

Generic Names:

  • Aklief

Uses:

  • Treats acne.

Therapeutic Classes:

  • Antiacne

Forms:

  • Cream

How it’s taken:

  • On the skin

What is Aklief used for?

What form(s) does Aklief come in

  • Cream

What are common Aklief doses?

  • Pump Btl 45GM of 0.005%

Common Aklief prescriptions

  • Aklief
    45gm of 0.005% pump btl

How to take Aklief

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • This medicine is for use only on the skin. Do not get it into your eyes, nose, or mouth. If you do, rinse the area right away with plenty of water. Do not use on skin areas that have cuts, scrapes, sunburn, or an itchy, scaly, red rash.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • To use: Gently wash your face with mild soap. Remove any makeup before applying the cream to the face. Rinse and pat your skin dry. Apply a pea-sized amount to lightly cover your face or upper body (including chest, shoulders, back). Wash your hands after applying the cream. You may apply a moisturizing sunscreen in the morning, and wear protective clothing while using this medicine. You can also use a cream or lotion to soften or moisturize your skin after you apply the cream.

  • Topical application routeDo not cover the treated area with a bandage unless directed by your doctor.

  • Missed dose: Topical application routeApply a dose as soon as you can. If it is almost time for your next dose, wait until then and apply a regular dose. Do not apply extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

What to do if you miss a dose of Aklief

Aklief contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to trifarotene.

Aklief warnings

  • Tell your doctor if you are pregnant, or if you have eczema, other skin problems, or sunburn.

  • Tell your doctor if you are breastfeeding or planning to breastfeed. Do not apply the cream directly to the nipple and areola to avoid direct exposure to the baby.

  • Topical application routeDo not use this medicine to treat a skin problem your doctor has not examined.

  • This medicine makes your skin more sensitive to irritation and more likely to burn. Avoid exposing your skin to wind, cold weather, and sunlight, even on cloudy days. Do not use a sunlamp or tanning bed. Use a sunscreen or sunblock lotion with a sun protection factor (SPF) of at least 15 on a regular basis. Wear protective clothing when you are outside.

  • Avoid the use of waxing as a hair removal method on the skin treated with this medicine.

  • Call your doctor if your symptoms do not improve or if they get worse.

  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Aklief interactions

  • Do not use any other medicines on the treated skin areas without asking your doctor. Avoid using any skin care products that can dry or irritate your skin. These include harsh skin cleansers, hair removal products, soaps or cosmetics that cause dryness, or products that contain alcohol or astringents.

Aklief side effects

Serious Side Effects

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Blisters, swelling, rash, or red, scaly, crusty skin

  • Severe skin itching, burning, redness, peeling, or pain

Less Serious Side Effects

  • Mild skin itching, peeling, stinging, burning, or dryness

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