What is Alka-Seltzer Heartburn: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Jan 13, 2021

Alka-Seltzer Heartburn overview

BRAND NAMES:

  • Alka-Seltzer Heartburn, Alka-Seltzer Heartburn Relief

Generic Names:

  • Alka-Seltzer Heartburn

Uses:

  • Treats heartburn, acid indigestion, and upset stomach.

Therapeutic Classes:

  • Antidote, Antacid, Sodium Bicarbonate Containing

Forms:

  • Packet, Granule, Fizzy Tablet

How it’s taken:

  • By mouth

What is Alka-Seltzer Heartburn used for?

What form(s) does Alka-Seltzer Heartburn come in

  • Packet

  • Granule

  • Fizzy Tablet

What are common Alka-Seltzer Heartburn doses?

  • Box 36 Tablets Effervescent

How to take Alka-Seltzer Heartburn

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Follow the instructions on the medicine label if you are using this medicine without a prescription.

  • If you are using the effervescent tablet form of this medicine, dissolve the tablets fully in 4 ounces of water. Drink all of this mixture right away.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Follow the instructions on the medicine label if you are using this medicine without a prescription.

  • If you are using the effervescent tablet form of this medicine, dissolve the tablets fully in 4 ounces of water. Drink all of this mixture right away.

What to do if you miss a dose of Alka-Seltzer Heartburn

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Alka-Seltzer Heartburn contraindications

  • You should not use this medicine if you have had an allergic reaction to sodium bicarbonate or citric acid.

Alka-Seltzer Heartburn warnings

  • Make sure your doctor knows if you are pregnant or breast feeding.

  • Tell your doctor if your symptoms last for longer than 14 days.

  • The effervescent tablet form of this medicine contains sodium and phenylalanine. Before using an effervescent tablet, tell your doctor if you are on a salt-restricted diet, or if you have phenylketonuria.

Alka-Seltzer Heartburn interactions

  • There are many other medicines that should not be taken together with an antacid, such as sodium bicarbonate. Tell your doctor about all other medicines you are using.

  • The effervescent tablet form of this medicine contains sodium and phenylalanine. Before using an effervescent tablet, tell your doctor if you are on a salt-restricted diet, or if you have phenylketonuria.

  • Tell your doctor if your symptoms last for longer than 14 days.

Alka-Seltzer Heartburn side effects

Serious Side Effects

  • Swelling in your hands, ankles, or feet.

  • Severe stomach pain.

  • Worsening stomach discomfort or new symptoms.