What is Amaryl: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Amaryl overview

BRAND NAMES:

  • Glimepiride AvPak, Amaryl

Generic Names:

  • Glimepiride

Uses:

  • Treats type 2 diabetes.

Therapeutic Classes:

  • Hypoglycemic

Forms:

  • Tablet

How it’s taken:

  • By mouth

What is Amaryl used for?

Glimepiride is a medication used to treat type 2 diabetes. Glimepiride belongs to a class of medications called sulfonylurea drugs. Glimepiride stimulates the pancreas to produce more insulin. Glimepiride is a generic medication also marketed under the brand name Amaryl sold by Sanofi-Aventis. Glimepiride use was approved by the FDA in 1995. In the treatment of type 2 diabetes, the used of glimepiride is common. Glimepiride is not used to treat type 1 diabetes.

What form(s) does Amaryl come in

  • Tablet

What are common Amaryl doses?

  • Tablet 1MG

  • Tablet 2MG

  • Tablet 4MG

Common Amaryl prescriptions

  • Amaryl
    1mg tablet

  • Amaryl
    2mg tablet

  • Amaryl
    4mg tablet

How to take Amaryl

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • Take this medicine with breakfast or your first main meal of the day, unless your doctor tells you differently.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • Take this medicine with breakfast or your first main meal of the day, unless your doctor tells you differently.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

What to do if you miss a dose of Amaryl

Amaryl contraindications

  • This medicine is not right for everyone. Do not use if you had an allergic reaction to glimepiride or a sulfa drug.

Amaryl warnings

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart or blood vessel problems, adrenal or pituitary gland problems, or G6PD deficiency. Tell your doctor if you drink alcohol.

  • This medicine may cause the following problems:Higher risk of heart or blood vessel problemsLow blood sugar

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Amaryl interactions

  • Some foods and medicines can affect how glimepiride works. Tell your doctor if you are using cyclophosphamide, danazol, disopyramide, fluoxetine, miconazole, niacin, pentoxifylline, phenobarbital, phenytoin, probenecid, propoxyphene, somatropin, sulfinpyrazone, or a blood thinner (such as warfarin).

  • Tell your doctor if you are also using a beta-blocker or ACE inhibitor blood pressure medicine, stomach medicine, cholesterol medicine, birth control pills, medicine to treat an infection, an NSAID pain or arthritis medicine, a sulfa medicine, an MAO inhibitor, a diuretic (water pill), thyroid medicine, or medicine to treat asthma.

  • There are many other drugs that can interact with glimepiride and affect your blood sugar levels. Make sure your doctor knows about all other medicines you are using.

  • If you are also taking colesevelam, take it at least 4 hours after you take glimepiride.

Amaryl side effects

Serious Side Effects

  • Trouble breathing, tiredness, uneven heartbeat, yellow skin or eyes

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Blistering, peeling, red skin rash

  • Shaking, trembling, sweating, fast or pounding heartbeat, lightheadedness, hunger, confusion

Less Serious Side Effects

  • Weight gain

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