Apretude is used in at-risk adults and adolescents to lower the risk of sexually acquired HIV-1 infection. The average retail price of Apretude is $5,780.34 per 1, 3ml of 600mg/3ml vial, but you can pay just $4,078.01 for 1, 3ml of 600mg/3ml vial of Apretude with a SingleCare prescription drug discount card. Apretude is administered by a healthcare provider. Your healthcare provider may provide the medication in the office. Or, you may need to get this medication from a specialty pharmacy. Your healthcare provider and insurance can give you additional information on where to get your medication.
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Prices updated: 04/19/2026
Apretude is used in at-risk adults and adolescents to lower the risk of sexually acquired HIV-1 infection. The average retail price of Apretude is $5,780.34 per 1, 3ml of 600mg/3ml vial, but you can pay just $4,078.01 for 1, 3ml of 600mg/3ml vial of Apretude with a SingleCare prescription drug discount card. Apretude is administered by a healthcare provider. Your healthcare provider may provide the medication in the office. Or, you may need to get this medication from a specialty pharmacy. Your healthcare provider and insurance can give you additional information on where to get your medication.
Apretude is used in at-risk adults and adolescents to lower the risk of sexually acquired HIV-1 infection. The average retail price of Apretude is $5,780.34 per 1, 3ml of 600mg/3ml vial, but you can pay just $4,078.01 for 1, 3ml of 600mg/3ml vial of Apretude with a SingleCare prescription drug discount card. Apretude is administered by a healthcare provider. Your healthcare provider may provide the medication in the office. Or, you may need to get this medication from a specialty pharmacy. Your healthcare provider and insurance can give you additional information on where to get your medication.
Your healthcare provider will tell you where you will get your medication. This may be directly at the provider’s office, or a specialty pharmacy or regular pharmacy. The standard out-of-pocket cost of Apretude without health insurance is $5,780.34 per 1, 3ml of 600mg/3ml vial though you can save using a SingleCare Apretude coupon to pay only $4,078.01 for 1, 3ml of 600mg/3ml vial of Apretude. If you don’t have access to an insurance plan, you can still use SingleCare for free Apretude savings.
Each insurance formulary is different, but many insurers do cover Apretude. The cost of Apretude with insurance coverage varies depending on your plan - check with your insurance company for specific drug coverage and copay details. If your insurance does not cover Apretude, you can use SingleCare to get discounts on Apretude at your participating pharmacy. Additionally, you can also use SingleCare coupons if you have Medicare or Medicaid. If Medicare or Medicaid don’t cover your Apretude prescription, you can use SingleCare instead—although most Medicaid plans now cover Apretude. Go to the SingleCare website or app to compare the lowest price of Apretude with SingleCare versus your copay with insurance or Medicare. You can also visit ViiVConnect to find out more about the Apretude Savings Program and other savings options.
Apretude costs with Medicare will vary by plan, prescription, and coverage stage. Refer to your plan’s drug formulary to find out whether your Medicare Part D or Medicare Advantage plan covers Apretude and how much the copay or coinsurance is. If Apretude is not covered by Medicare or if you have not met your plan’s deductible, you may have to pay the full price of $5,780.34 for 1, 3ml of 600mg/3ml vial. In that case, using a SingleCare coupon for Apretude could save you more money than Medicare. Our lowest price for Apretude is currently $4,078.01 for 1, 3ml of 600mg/3ml vial.
Apretude is a brand-name drug made by Viiv Healthcare. There is no generic substitute for Apretude. Use a SingleCare prescription drug discount card to pay $4,078.01 for 1, 3ml of 600mg/3ml vial.
Apretude is classified as an HIV-1 integrase strand transfer inhibitor (INSTI). Manufactured by the pharmaceutical company ViiV Healthcare Company, it is FDA-approved for use in at-risk adults and adolescents (weighing at least 35 kg, or 77 lbs) for pre-exposure prophylaxis (PrEP) to reduce the risk of getting HIV-1 infection through sex. HIV is the virus that can cause acquired immunodeficiency syndrome (AIDS).
Patients must have a negative HIV-1 test before using Apretude. You will either start treatment with Apretude, or take Vocabria (oral cabotegravir) for four weeks first.
Apretude is administered by a healthcare provider by intramuscular injection (injection into a muscle) of the gluteal area. It is given once a month for two months, then once every two months after that.
Common side effects of Apretude include:
Injection site reactions such as pain, swelling, redness, and bruising
Stomach problems like nausea, vomiting, diarrhea, stomach pain, and gas
Headache
Fever
Fatigue
Sleep problems
Muscle and/or back pain
Rash
Appetite loss
Sleepiness
Upper respiratory tract infection
If you have symptoms of an allergic reaction, such as hives, trouble breathing or swallowing, or swelling of the face, lips, tongue, or throat, get emergency medical help. Other serious side effects may include liver problems, depression, or suicidal thoughts and behaviors. Be alert to changes in mood and behavior while taking this medication, and report any changes to your healthcare provider right away.
In clinical trials, people who took Apretude had a small amount of weight gain, anywhere from an average of two to 9 pounds over about two years.
In terms of use for PrEP, two studies compared Apretude vs. Truvada and found that Apretude was more effective in preventing HIV. This may be because Truvada is a daily pill, while Apretude is given monthly for two months, then every two months, making it easier to adhere to the regimen. However, the best drug for you can only be determined by your healthcare provider. See your healthcare provider for professional medical advice on the best medicine for you.
After receiving her doctorate from the University of Pittsburgh School of Pharmacy, Karen Berger, Pharm.D., has worked in both chain and independent community pharmacies. She currently works at an independent pharmacy in New Jersey. Dr. Berger enjoys helping patients understand medical conditions and medications—both in person as a pharmacist, and online as a medical writer and reviewer.
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SingleCare is a prescription discount service that offers free coupons on thousands of prescription drugs. It can be used whether you have insurance, Medicare, Medicaid, or none of the above, but it cannot be combined with insurance.
SingleCare provides transparent drug pricing, so you can compare discounts at pharmacies near you. Browse singlecare.com to find drug discounts, helpful information about your prescription, and resources to help you make informed health decisions.
Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2026 SingleCare Administrators. All rights reserved