Odefsey is a combination prescription medicine that is used to treat Human Immunodeficiency Virus-1 (HIV-1). It is approved to use in patients who are 12 years of age and older and weigh at least 77 pounds or more. There is currently no generic version of Odefsey in the U.S. You can pay $3,913.98 for 30, 200-25-25mg tablets of Odefsey instead of the average retail price of $4,915.36. Browse our Odefsey coupons here and learn more about how Odefsey works.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.
Prices updated: 05/05/2026
Odefsey is a combination prescription medicine that is used to treat Human Immunodeficiency Virus-1 (HIV-1). It is approved to use in patients who are 12 years of age and older and weigh at least 77 pounds or more. There is currently no generic version of Odefsey in the U.S. You can pay $3,913.98 for 30, 200-25-25mg tablets of Odefsey instead of the average retail price of $4,915.36. Browse our Odefsey coupons here and learn more about how Odefsey works.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Odefsey Retail Price | Odefsey SingleCare Price |
|---|---|---|
| CVS Pharmacy | $4737.00 | $4094.10 |
| Walgreens | $4837.50 | $4138.80 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Odefsey is a combination prescription medicine that is used to treat Human Immunodeficiency Virus-1 (HIV-1). It is approved to use in patients who are 12 years of age and older and weigh at least 77 pounds or more. There is currently no generic version of Odefsey in the U.S. You can pay $3,913.98 for 30, 200-25-25mg tablets of Odefsey instead of the average retail price of $4,915.36. Browse our Odefsey coupons here and learn more about how Odefsey works.
Without insurance, you could pay a cash price of about $4,915.36 for Odefsey. You can save on the cost of your Odefsey prescriptions by using SingleCare instead of insurance. With a free discount card from SingleCare, you could pay the reduced price of $3,913.98 for Odefsey at SingleCare participating pharmacies such as Walmart, Walgreens, and CVS.
How much you pay for Odefsey with insurance tends to vary by the individual health insurance plan. Your pharmacist can help to calculate the cost and your copay for this prescription medication. However, with a SingleCare prescription savings card, you could pay our lowest price of $3,913.98 to refill your Odefsey prescription. This may be cheaper than what you would pay with your insurance. Head over to your local pharmacy like CVS Pharmacy, Walmart, Kroger, or Duane Reade to compare retail prices and start saving.
Odefsey is currently covered by Medicare Part D and Advantage Plans. However, you can still save money on Odefsey prices by using a SingleCare Odefsey coupon. With our free discount card you could pay as little as $3,913.98 for your Odefsey refills.
Odefsey is a brand-name prescription medication. Currently, there are no generic equivalents to Odefsey.
Odefsey is a combination prescription medicine that is used to treat Human Immunodeficiency Virus-1 (HIV-1) in patients who are 12 years of age and older and weigh at least 77 pounds (35 kgs) or more.
Odefsey contains the medicines emtricitabine, rilpivirine, and tenofovir alafenamide but it is not a cure for HIV-1 or AIDS.
Before you take Odefsey, tell your doctor about other medical conditions you may have including Hepatitis B or C, liver or kidney problems, if you have a history of depression or suicidal thoughts, and if you are pregnant, breastfeeding, or plan on becoming pregnant. You should also provide your healthcare provider with a list of all the medications you are using including prescription medicines, over-the-counter drugs, vitamins, and herbal supplements.
Do not use Odefsey if you are using any of the following medications:
Anticonvulsants: carbamazepine, oxcarbazepine, phenobarbital, or phenytoin
Steroid: dexamethasone
St. John's wort
Proton Pump Inhibitors (PPIs): dexlansoprazole, esomeprazole, lansoprazole, omeprazole, pantoprazole, or rabeprazole
Rifampin or rifapentine
You should only use Odefsey as prescribed by your doctor. Odefsey is usually taken once daily with a meal or as directed by your doctor. Do not change your dose or stop taking Odefsey without first getting medical advice from your healthcare provider. Do not miss any doses of Odefsey. As your supply of Odefsey pills gets lower, talk to your doctor or pharmacist about refilling your prescription. This is very important because the amount of virus in your blood may increase if the medicine is stopped, even for a short time. The virus may develop resistance to Odefsey and become harder to treat.
Each time you fill or refill your prescription for Odefsey, you will receive a Medication Guide that details warnings, side effects, and other important information. Read the Medication Guide carefully each time you fill your prescription, and consult your doctor with any questions or concerns.
The most common side effects of Odefsey include headaches, problems sleeping, and nausea. Mood changes, changes in body fat, kidney or bone problems, or changes in the immune system may occur.
Severe skin rash, fever, skin blisters, trouble breathing, redness or swelling of the eyes, and dark or tea-colored urine require fast medical attention. You may also get a change in liver enzymes, especially in patients with Hepatitis B or C.
Odefsey has a boxed warning, which is the strongest warning required by the U.S. Food and Drug Administration (FDA). The warning states that severe acute exacerbation of hepatitis B has occurred in patients who have both HIV-1 and hepatitis B and have stopped taking medications that contain emtricitabine and/or tenofovir disoproxil fumarate. This can happen when Odefsey is stopped. Liver function should be monitored carefully.
This is not a complete list of the possible side effects of Odefsey, and others can occur. For a complete list of side effects you can visit the Odefsey website, or you can ask a healthcare professional what side effects you can expect and how to address them. You can also report your side effects or allergic reactions to the FDA.
After receiving her doctorate from the University of Pittsburgh School of Pharmacy, Karen Berger, Pharm.D., has worked in both chain and independent community pharmacies. She currently works at an independent pharmacy in New Jersey. Dr. Berger enjoys helping patients understand medical conditions and medications—both in person as a pharmacist, and online as a medical writer and reviewer.
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SingleCare is a prescription discount service that offers free coupons on thousands of prescription drugs. It can be used whether you have insurance, Medicare, Medicaid, or none of the above, but it cannot be combined with insurance.
SingleCare provides transparent drug pricing, so you can compare discounts at pharmacies near you. Browse singlecare.com to find drug discounts, helpful information about your prescription, and resources to help you make informed health decisions.
Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2026 SingleCare Administrators. All rights reserved