Benlysta is a brand-name prescription medication used to treat lupus, specifically active systemic lupus erythematosus (SLE) and active lupus nephritis. The active ingredient in Benlysta is belimumab. Benlysta is a specialty medication that is either administered in a healthcare facility or self-injected at home (supplied by certain specialty pharmacies for at-home use).
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Prices updated: 04/01/2026
Benlysta is a brand-name prescription medication used to treat lupus, specifically active systemic lupus erythematosus (SLE) and active lupus nephritis. The active ingredient in Benlysta is belimumab. Benlysta is a specialty medication that is either administered in a healthcare facility or self-injected at home (supplied by certain specialty pharmacies for at-home use).
Benlysta is a brand-name prescription medication used to treat lupus, specifically active systemic lupus erythematosus (SLE) and active lupus nephritis. The active ingredient in Benlysta is belimumab. Benlysta is a specialty medication that is either administered in a healthcare facility or self-injected at home (supplied by certain specialty pharmacies for at-home use).
The price for Benlysta without insurance depends on several factors, such as the quantity and day supply. For those who self-inject at home, a single dose of Benlysta for self-injection costs about $1,211—however, it is typically sold in a pack of four at an average price of $4,843. For those who receive an intravenous infusion from a healthcare provider at a medical facility, the price varies by patient as it is dosed by weight.
The cost of Benlysta with insurance varies by plan and the quantity prescribed. Insurance plans generally help cover the cost of Benlysta, but you may be responsible for a copay or coinsurance amount. Consult your insurance plan or pharmacist for more information about the cost of Benlysta with your plan. You can also use the Benlysta Gateway program, which works with patients to understand coverage details and estimate out-of-pocket costs. Keep in mind that you could save more with SingleCare than with insurance, so ask your pharmacist to compare prices.
You may be able to get this medication either at a healthcare provider's office or from certain specialty pharmacies. There are various specialty pharmacies that may provide Benlysta in your local area. The specific pharmacy you use will depend on your insurance plan.
Medicare prescription drug programs may or may not cover Benlysta. In certain cases, the healthcare provider may need to submit paperwork for a prior authorization to prove to the insurance company that the medicine is medically necessary. Medicare Part B may cover some of the cost if you receive Benlysta in a healthcare facility. If you receive a supply for home use, you can refer to your plan's drug formulary to find out if your Medicare Part D or Medicare Advantage plan covers Benlysta. You can also register with Benlysta Gateway, which can provide more information about costs with your specific Medicare insurance plan.
Benlysta is a brand-name prescription medicine. Because Benlysta is a biologic medicine, the generic version is called a biosimilar. However, no pharmaceutical companies offer a biosimilar for Benlysta at this time. Benlysta was initially approved by the FDA in 2011. GlaxoSmithKline is the manufacturer of Benlysta.
Benlysta is a prescription medication that treats systemic lupus erythematosus (SLE), a chronic condition where the immune system mistakenly attacks healthy tissues. It is typically prescribed when other treatments have not been successful in managing the disease. Unlike some autoimmune diseases that target specific tissues, SLE can affect multiple organs, including the skin, heart, lungs, gastrointestinal system, central nervous system, and joints.
Benlysta is also used to treat patients with an autoimmune disorder of the kidneys caused by SLE, called lupus nephritis. Benlysta can be used in adults and children 5 years and older.
Benlysta works by blocking a protein in the immune system called B lymphocyte stimulator (BlyS). By lowering the activity of this protein, Benlysta helps reduce the overactive immune response in lupus, which can help relieve symptoms and prevent flare-ups.
Benlysta is administered as an intravenous injection (through the vein) or a subcutaneous injection (under the skin) using a prefilled syringe or autoinjector. The dosage and frequency of administration depend on the patient's condition and response to treatment. Always follow the instructions provided by your healthcare provider if you are self-injecting the medication.
Common side effects of Benlysta include but are not limited to:
Pain, redness, or swelling at the injection site
Nausea
Diarrhea
Fever
Stuffy or runny nose
Sore throat
Headache
Trouble sleeping
Depression
Serious side effects may include severe infections, allergic reactions, and a condition called progressive multifocal leukoencephalopathy (PML), which may cause symptoms like mental confusion, weakness, vision problems, and difficulties with coordination.
Mental and mood changes include depression, anxiety, and, though rare, suicidal thoughts and behaviors. Patients who take Benlysta should be closely monitored for any changes in mood or behavior.
Allergic reactions are rare but potentially life-threatening. If you experience any allergic reactions to Benlysta, such as hives, difficulty breathing, low blood pressure, or swelling of the face, lips, tongue, or throat, get emergency medical help.
This is not a full list of side effects, and others may occur. Consult a healthcare professional for additional information and medical advice.
While taking Benlysta, you should not receive any live vaccines. If you are unsure whether a certain vaccine is live, ask your healthcare provider or pharmacist.
Weight loss is not a common side effect of Benlysta. However, weight loss may indicate other underlying problems, such as infections or depression, which may be side effects of Benlysta. If you experience significant weight changes while taking this medication, consult your healthcare provider. They can help determine if the weight loss is related to the medication or another underlying issue.
Benlysta and hydroxychloroquine are both used to treat lupus but are different medications. Hydroxychloroquine, also known as Plaquenil, is an antimalarial drug, while Benlysta is a monoclonal antibody that targets specific proteins in the immune system. Both drugs may be used together to manage lupus.
Benlysta is typically a long-term treatment for conditions like SLE and lupus nephritis. Patients usually continue taking it as long as they tolerate it well and it effectively manages their symptoms. However, it may take several months to see the full benefits of the medication.
Gerardo Sison, Pharm.D., graduated from the University of Florida. He has worked in both community and hospital settings, providing drug information and medication therapy management services. As a medical writer, he hopes to educate and empower patients to better manage their health and navigate their treatment plans.
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Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
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