Benlysta Coupons & Prices

Benlysta is a brand-name prescription medication used to treat lupus, specifically active systemic lupus erythematosus (SLE) and active lupus nephritis. The active ingredient in Benlysta is belimumab. Benlysta is a specialty medication that is either administered in a healthcare facility or self-injected at home (supplied by certain specialty pharmacies for at-home use).

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Benlysta coupon at Kroger Pharmacy
$5029.39
$ 5,026
$3 off with signupwith signup

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This coupon is not insurance.
Benlysta coupon at Harris Teeter Pharmacy
$5029.39
$ 5,026
$3 off with signupwith signup
Benlysta coupon at Walgreens Pharmacy
$5216.08
$ 5,213
$3 off with signupwith signup
Benlysta coupon at Food Lion Pharmacy
$ 5,248
Benlysta coupon at Publix Pharmacy
$ 5,310
Benlysta coupon at Walmart Neighborhood Market Pharmacy
$5399.79
$ 5,397
$3 off with signupwith signup
$5399.79
$ 5,397
$3 off with signupwith signup
$5430.10
$ 5,427
$3 off with signupwith signup

About SingleCare Pricing

SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.

Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.

Prices updated: 04/01/2026

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4.8 average rating
About Benlysta

Benlysta is a brand-name prescription medication used to treat lupus, specifically active systemic lupus erythematosus (SLE) and active lupus nephritis. The active ingredient in Benlysta is belimumab. Benlysta is a specialty medication that is either administered in a healthcare facility or self-injected at home (supplied by certain specialty pharmacies for at-home use).

About Benlysta

Benlysta is a brand-name prescription medication used to treat lupus, specifically active systemic lupus erythematosus (SLE) and active lupus nephritis. The active ingredient in Benlysta is belimumab. Benlysta is a specialty medication that is either administered in a healthcare facility or self-injected at home (supplied by certain specialty pharmacies for at-home use).

Benlysta FAQs

Medically reviewed by Gerardo SisonPharm.D.
Licensed Pharmacist

How can I pay for Benlysta without insurance?

The price for Benlysta without insurance depends on several factors, such as the quantity and day supply. For those who self-inject at home, a single dose of Benlysta for self-injection costs about $1,211—however, it is typically sold in a pack of four at an average price of $4,843. For those who receive an intravenous infusion from a healthcare provider at a medical facility, the price varies by patient as it is dosed by weight.

How much does Benlysta cost with insurance?

The cost of Benlysta with insurance varies by plan and the quantity prescribed. Insurance plans generally help cover the cost of Benlysta, but you may be responsible for a copay or coinsurance amount. Consult your insurance plan or pharmacist for more information about the cost of Benlysta with your plan. You can also use the Benlysta Gateway program, which works with patients to understand coverage details and estimate out-of-pocket costs. Keep in mind that you could save more with SingleCare than with insurance, so ask your pharmacist to compare prices.

Where can I get Benlysta?

You may be able to get this medication either at a healthcare provider's office or from certain specialty pharmacies. There are various specialty pharmacies that may provide Benlysta in your local area. The specific pharmacy you use will depend on your insurance plan.

Does Medicare cover Benlysta and how much does it cost?

Medicare prescription drug programs may or may not cover Benlysta. In certain cases, the healthcare provider may need to submit paperwork for a prior authorization to prove to the insurance company that the medicine is medically necessary. Medicare Part B may cover some of the cost if you receive Benlysta in a healthcare facility. If you receive a supply for home use, you can refer to your plan's drug formulary to find out if your Medicare Part D or Medicare Advantage plan covers Benlysta. You can also register with Benlysta Gateway, which can provide more information about costs with your specific Medicare insurance plan.

Is there a generic of Benlysta?

Benlysta is a brand-name prescription medicine. Because Benlysta is a biologic medicine, the generic version is called a biosimilar. However, no pharmaceutical companies offer a biosimilar for Benlysta at this time. Benlysta was initially approved by the FDA in 2011. GlaxoSmithKline is the manufacturer of Benlysta.

What is Benlysta?

Benlysta is a prescription medication that treats systemic lupus erythematosus (SLE), a chronic condition where the immune system mistakenly attacks healthy tissues. It is typically prescribed when other treatments have not been successful in managing the disease. Unlike some autoimmune diseases that target specific tissues, SLE can affect multiple organs, including the skin, heart, lungs, gastrointestinal system, central nervous system, and joints. 

Benlysta is also used to treat patients with an autoimmune disorder of the kidneys caused by SLE, called lupus nephritis. Benlysta can be used in adults and children 5 years and older.

How does Benlysta work?

Benlysta works by blocking a protein in the immune system called B lymphocyte stimulator (BlyS). By lowering the activity of this protein, Benlysta helps reduce the overactive immune response in lupus, which can help relieve symptoms and prevent flare-ups.

How do I use Benlysta?

Benlysta is administered as an intravenous injection (through the vein) or a subcutaneous injection (under the skin) using a prefilled syringe or autoinjector. The dosage and frequency of administration depend on the patient's condition and response to treatment. Always follow the instructions provided by your healthcare provider if you are self-injecting the medication.

What are the side effects of Benlysta?

Common side effects of Benlysta include but are not limited to: 

  • Pain, redness, or swelling at the injection site

  • Nausea 

  • Diarrhea 

  • Fever 

  • Stuffy or runny nose 

  • Sore throat 

  • Headache 

  • Trouble sleeping

  • Depression

Serious side effects may include severe infections, allergic reactions, and a condition called progressive multifocal leukoencephalopathy (PML), which may cause symptoms like mental confusion, weakness, vision problems, and difficulties with coordination. 

Mental and mood changes include depression, anxiety, and, though rare, suicidal thoughts and behaviors. Patients who take Benlysta should be closely monitored for any changes in mood or behavior.

Allergic reactions are rare but potentially life-threatening. If you experience any allergic reactions to Benlysta, such as hives, difficulty breathing, low blood pressure, or swelling of the face, lips, tongue, or throat, get emergency medical help.

This is not a full list of side effects, and others may occur. Consult a healthcare professional for additional information and medical advice.

While taking Benlysta, you should not receive any live vaccines. If you are unsure whether a certain vaccine is live, ask your healthcare provider or pharmacist. 

Do you lose weight on Benlysta?

Weight loss is not a common side effect of Benlysta. However, weight loss may indicate other underlying problems, such as infections or depression, which may be side effects of Benlysta. If you experience significant weight changes while taking this medication, consult your healthcare provider. They can help determine if the weight loss is related to the medication or another underlying issue.

Is Benlysta the same as hydroxychloroquine?

Benlysta and hydroxychloroquine are both used to treat lupus but are different medications. Hydroxychloroquine, also known as Plaquenil, is an antimalarial drug, while Benlysta is a monoclonal antibody that targets specific proteins in the immune system. Both drugs may be used together to manage lupus.

How long do you take Benlysta for?

Benlysta is typically a long-term treatment for conditions like SLE and lupus nephritis. Patients usually continue taking it as long as they tolerate it well and it effectively manages their symptoms. However, it may take several months to see the full benefits of the medication.

Medically reviewed by Gerardo SisonPharm.D.
Licensed Pharmacist

Gerardo Sison, Pharm.D., graduated from the University of Florida. He has worked in both community and hospital settings, providing drug information and medication therapy management services. As a medical writer, he hopes to educate and empower patients to better manage their health and navigate their treatment plans.

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Where are Benlysta coupons from SingleCare accepted?

SingleCare is accepted at most national pharmacies and grocers, including the following:

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