What is Boniva: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Boniva overview

BRAND NAMES:

  • Boniva, Boniva

Generic Names:

  • Ibandronate Sodium

Uses:

  • Treats or prevents osteoporosis., Treats or prevents osteoporosis.

Therapeutic Classes:

  • Calcium Regulator, Calcium Regulator

Forms:

  • Injectable, Tablet

How it’s taken:

  • By mouth, By injection

What is Boniva used for?

What form(s) does Boniva come in

  • Injectable

  • Tablet

What are common Boniva doses?

  • Disp Pack 3 Tablets

  • Syringe 3ML of 3MG/3ML

Common Boniva prescriptions

  • Boniva
    3 tablets disp pack

  • Boniva
    3ml of 3mg/3ml syringe

  • Boniva
    150mg tablet

How to take Boniva

  • If you take this medicine once each month, take it on the same date each month. Choose a day that best fits your activity schedule and will be easy to remember.

  • Sit or stand while you take this medicine. Do not lie down for at least 60 minutes after you take the medicine, and do not lie down until after you have eaten.

  • Use plain water to take your medicine. The medicine may not work as well if you use other liquids.

  • Swallow the tablet whole with 6 to 8 ounces of water. Do not chew or suck on the tablet.

  • Wait at least 60 minutes after you take this medicine before you eat or drink or take any other medicine. This will help your body absorb the medicine.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Missed dose: Monthly dose: If your next regular dose is more than 7 days away, take the missed dose the next morning after you remember. Then take a dose on your regular day and continue with your schedule.If your next regular dose is 1 to 7 days away, skip the missed dose and take the next dose on your regular day. Continue with your normal schedule.Do not use extra medicine to make up for a missed dose.Daily dose: Wait until the next morning to take a dose. Do not use extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Take this medicine in the morning on an empty stomach. Follow the directions exactly to lower the risk of esophagus problems.

  • Take this medicine in the morning on an empty stomach. Follow the directions exactly to lower the risk of esophagus problems.

  • Missed dose: Monthly dose: If your next regular dose is more than 7 days away, take the missed dose the next morning after you remember. Then take a dose on your regular day and continue with your schedule.If your next regular dose is 1 to 7 days away, skip the missed dose and take the next dose on your regular day. Continue with your normal schedule.Do not use extra medicine to make up for a missed dose.Daily dose: Wait until the next morning to take a dose. Do not use extra medicine to make up for a missed dose.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Use plain water to take your medicine. The medicine may not work as well if you use other liquids.

  • Wait at least 60 minutes after you take this medicine before you eat or drink or take any other medicine. This will help your body absorb the medicine.

  • Sit or stand while you take this medicine. Do not lie down for at least 60 minutes after you take the medicine, and do not lie down until after you have eaten.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Swallow the tablet whole with 6 to 8 ounces of water. Do not chew or suck on the tablet.

  • If you take this medicine once each month, take it on the same date each month. Choose a day that best fits your activity schedule and will be easy to remember.

  • Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein. This medicine is usually given every 3 months.

  • Injection routeA nurse or other health provider will give you this medicine.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Missed dose: Injection routeCall your doctor or pharmacist for instructions.

  • Missed dose: Injection routeCall your doctor or pharmacist for instructions.

  • Injection routeA nurse or other health provider will give you this medicine.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein. This medicine is usually given every 3 months.

What to do if you miss a dose of Boniva

Boniva contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to ibandronate, or you have esophagus problems or trouble swallowing. Do not use it if you cannot stand or sit upright for at least 60 minutes after you take the medicine.

  • This medicine is not right for everyone. You should not receive it if you had an allergic reaction to ibandronate.

Boniva warnings

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, heartburn, anemia, blood clotting problems, ulcers or other stomach or bowel problems, a vitamin D deficiency, or a history of cancer. Tell your doctor if you have dental problems or if you wear dentures.

  • This medicine may cause the following problems:Low calcium levelsKidney problemsIncreased risk for a thigh bone fracture

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine could cause jaw problems, especially if you have a tooth pulled or have other dental work.

  • This medicine may interact with the dye used for bone scans.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Unusual pain in your thigh, groin, or hip

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, heartburn, anemia, blood clotting problems, ulcers or other stomach or bowel problems, a vitamin D deficiency, or a history of cancer. Tell your doctor if you have dental problems or if you wear dentures.

  • This medicine may cause the following problems:Damage to your esophagusLow calcium levelsIncreased risk for a thigh bone fracture

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine could cause jaw problems, especially if you have a tooth pulled or have other dental work.

  • This medicine may interact with the dye used for bone scans.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Unusual pain in your thigh, groin, or hip

Boniva interactions

  • Some medicines can affect how ibandronate works. Tell your doctor if you are using any of the following:Cancer medicines or treatmentsNSAID pain or arthritis medicine (including aspirin, diclofenac, ibuprofen, naproxen)Steroids (including dexamethasone, hydrocortisone, methylprednisolone, prednisolone, prednisone)

  • Take this medicine at least 60 minutes before you take any other oral medicine, including aluminum, magnesium, iron, or calcium supplements, or antacids.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine could cause jaw problems, especially if you have a tooth pulled or have other dental work.

  • This medicine may interact with the dye used for bone scans.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Some medicines can affect how ibandronate works. Tell your doctor if you are using any of the following:Cancer medicines or radiation treatmentNSAID pain or arthritis medicine (including aspirin, celecoxib, diclofenac, ibuprofen, naproxen)Steroids (including dexamethasone, hydrocortisone, methylprednisolone, prednisolone, prednisone)

  • This medicine may cause the following problems:Low calcium levelsKidney problemsIncreased risk for a thigh bone fracture

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine could cause jaw problems, especially if you have a tooth pulled or have other dental work.

  • This medicine may interact with the dye used for bone scans.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Boniva side effects

Serious Side Effects

  • Unusual pain in your thigh, groin, or hip

  • Muscle spasms or twitching, tingling or numbness in your fingers, toes, or around your mouth

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Difficult or painful swallowing

  • Severe bone, joint, or muscle pain

  • Pain, swelling, numbness, or a heavy feeling in your mouth or jaw, loose teeth, or other tooth problems

  • Chest pain, new or worsening heartburn, or a burning feeling in your throat

  • Severe bone, joint, or muscle pain

  • Unusual pain in your thigh, groin, or hip

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Change in how much or how often you urinate, blood in your urine, lower back or side pain

  • Muscle spasms or twitching, tingling or numbness in your fingers, toes, or around your mouth

  • Pain, swelling, numbness, or a heavy feeling in your mouth or jaw, loose teeth, or other tooth problems

Less Serious Side Effects

  • Pain, itching, burning, swelling, or a lump under your skin where the needle was placed

  • Cough, stuffy or runny nose, sore throat

  • Cough, runny or stuffy nose, sore throat

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