What is Cerebyx: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Cerebyx overview

BRAND NAMES:

  • Cerebyx, Cerebyx Novaplus, Fosphenytoin Sodium Novaplus

Generic Names:

  • Cerebyx

Uses:

  • Treats and prevents seizures.

Therapeutic Classes:

  • Anticonvulsant

Forms:

  • Injectable

How it’s taken:

  • By injection

What is Cerebyx used for?

What form(s) does Cerebyx come in

  • Injectable

What are common Cerebyx doses?

  • Vial 10ML of 500MG PE/10ML

Common Cerebyx prescriptions

  • Cerebyx
    10ml of 500mg pe/10ml vial

  • Cerebyx
    2ml of 100mg pe/2ml vial

How to take Cerebyx

  • This medicine is usually given only for a short time when you cannot take other forms of anticonvulsant medicine, such as when you are in the hospital or when you have surgery.

  • A nurse or other trained health professional will give you this medicine in a hospital. This medicine is given as a shot into a muscle or into a vein.

  • After your condition improves, your doctor might switch you to an oral medicine that works the same way. Talk to your doctor if you have any concerns about this.

  • A nurse or other trained health professional will give you this medicine in a hospital. This medicine is given as a shot into a muscle or into a vein.

  • This medicine is usually given only for a short time when you cannot take other forms of anticonvulsant medicine, such as when you are in the hospital or when you have surgery.

  • After your condition improves, your doctor might switch you to an oral medicine that works the same way. Talk to your doctor if you have any concerns about this.

What to do if you miss a dose of Cerebyx

Cerebyx contraindications

  • This medicine is not right for everyone. You should not receive it if you had an allergic reaction to fosphenytoin or similar medicines, if you are pregnant, if you have certain heart rhythm problems, or if you have had liver problems from using fosphenytoin or phenytoin.

Cerebyx warnings

  • Unusual bleeding, bruising, or weakness

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.

  • Tell your doctor if you are breastfeeding, or if you have kidney disease, liver disease, heart failure, low blood pressure, or porphyria.

  • This medicine may cause the following problems:Serious skin reactions (may happen after treatment has stopped)Drug reaction with eosinophilia and systemic symptoms (DRESS), which may damage organs such as the liver, kidney, or heartLiver problemsHigher blood sugar levels

  • This medicine may make you dizzy or drowsy. Do not drive or do anything that could be dangerous until you know how this medicine affects you.

  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Severe confusion, problems with balance or walking, slurred speech, tremors

Cerebyx interactions

  • Do not use this medicine together with delavirdine.

  • The list below includes some of the medicines that can interact with fosphenytoin. There are many other drugs not listed. Make sure your doctor knows the names of all the medicines you use, especially the following:Amiodarone, aspirin, chlordiazepoxide, chlorpropamide, cimetidine, clozapine, cyclosporine, diazepam, diazoxide, digoxin, disulfiram, folic acid, furosemide, isoniazid, methadone, methylphenidate, mexiletine, nifedipine, nimodipine, nisoldipine, omeprazole, quinidine, reserpine, rifampin, St John's wort, theophylline, tolbutamide, verapamil, vitamin D supplementsBirth control pillsBlood thinner (including ticlopidine, warfarin)Cancer medicineHIV/AIDS medicineMedicine to lower cholesterolMedicine to treat depressionMedicine to treat infection (including chloramphenicol, miconazole)Other medicines to treat seizures (including carbamazepine, lamotrigine)Phenothiazine medicine (including chlorpromazine, perphenazine, prochlorperazine, promethazine, thioridazine)Steroid medicine (including dexamethasone, hydrocortisone, methylprednisolone, prednisolone, prednisone)

  • Do not drink alcohol while you are using this medicine.

  • Tell your doctor if you are using a cancer medicine, birth control pills, medicine to treat an infection (such as chloramphenicol), medicine to treat HIV/AIDS, or medicine for a fungus infection (such as miconazole), a steroid medicine (such as hydrocortisone, methylprednisolone, prednisone, prednisolone, dexamethasone), medicine to lower cholesterol, medicine to treat depression, a phenothiazine medicine (such as chlorpromazine, perphenazine, promethazine, prochlorperazine, thioridazine), or a blood thinner (such as ticlopidine, warfarin).

  • Do not drink alcohol while you are using this medicine.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Cerebyx side effects

Serious Side Effects

  • Blistering, peeling, red skin rash

  • Fever, chills, cough, sore throat, and body aches

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Severe confusion, problems with balance or walking, slurred speech, tremors

  • Fast, slow, or pounding heartbeat, lightheadedness or fainting

  • Pain, changes in skin color, or swelling at or near the injection site

  • Unusual bleeding, bruising, or weakness

  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes

  • Fever, skin rash, or swollen glands in your armpits, neck, or groin

Less Serious Side Effects

  • Mild confusion, slurred speech, clumsiness, problems with balance

  • Burning, itching, or tingling feeling

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