What is Chlordiazepoxide-Amitriptyline: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Chlordiazepoxide-Amitriptyline overview

BRAND NAMES:

  • Limbitrol DS

Generic Names:

  • Chlordiazepoxide-Amitriptyline

Uses:

  • Treats depression caused by anxiety. This medicine is a combination of a benzodiazepine and a tricyclic antidepressant (TCA).

Therapeutic Classes:

  • Tricyclic Antidepressant/Benzodiazepine Combination

Forms:

  • Tablet

How it’s taken:

  • By mouth

What is Chlordiazepoxide-Amitriptyline used for?

Chlordiazepoxide-Amitriptyline contains benzodiazepine and a tricyclic antidepressant (TCA) and is used to treat patients with depression caused by anxiety. This combination drug works by targeting the chemicals in the brain that may be unbalanced causing depression and anxiety.

What form(s) does Chlordiazepoxide-Amitriptyline come in

  • Tablet

What are common Chlordiazepoxide-Amitriptyline doses?

  • Tablet 5-12.5MG

  • Tablet 10-25MG

Common Chlordiazepoxide-Amitriptyline prescriptions

  • chlordiazePOXIDE-Amitriptyline
    10-25mg tablet

  • chlordiazePOXIDE-Amitriptyline
    5-12.5mg tablet

How to take Chlordiazepoxide-Amitriptyline

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Drink extra fluids so you will urinate more often and help prevent kidney problems.

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Drink extra fluids so you will urinate more often and help prevent kidney problems.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

What to do if you miss a dose of Chlordiazepoxide-Amitriptyline

Chlordiazepoxide-Amitriptyline contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to chlordiazepoxide, amitriptyline, or similar medicines.

Chlordiazepoxide-Amitriptyline warnings

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.

  • Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.

  • This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

  • This medicine may cause the following problems:Changes in heart rhythm (including arrhythmia)Heart attack or stroke

  • This medicine may increase depression or thoughts of suicide. Tell your doctor right away if you start to feel more depressed or think about hurting yourself.

  • Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding, or if you have kidney disease, liver disease, heart or blood vessel disease, an overactive thyroid, or a history of glaucoma, seizures, or trouble urinating. Tell your doctor if you have a recent heart attack.

Chlordiazepoxide-Amitriptyline interactions

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.

  • Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.

  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.

  • Do not drink alcohol while you are using this medicine.

  • Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol.

  • Do not use this medicine if you have used an MAO inhibitor within the past 14 days.

  • Some foods and medicines can affect how this medicine works. Tell your doctor if you are using any of the following: Cimetidine, guanethidine, topiramateMedicine for heart rhythm problem (including flecainide, propafenone, quinidine)Other medicine to treat depression (including fluoxetine, paroxetine, sertraline)Phenothiazine medicine (including chlorpromazine, prochlorperazine, promethazine, thioridazine)

Chlordiazepoxide-Amitriptyline side effects

Serious Side Effects

  • Seizures or tremors

  • Fast, pounding, or uneven heartbeat

  • Chest pain that may spread to your arms, jaw, back, or neck, trouble breathing, nausea, unusual sweating, faintness

  • Changes in behavior, unusual thoughts of hurting yourself or others, trouble sleeping

  • Change in how much or how often you urinate, trouble urinating

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

Less Serious Side Effects

  • Dry mouth

  • Dizziness or drowsiness

  • Constipation

  • Blurred vision

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