What is Cholbam: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Aug 5, 2021

Cholbam overview

BRAND NAMES:

  • Cholbam

Generic Names:

  • Cholbam

Uses:

  • Treats bile acid synthesis disorders and peroxisomal disorders (including Zellweger spectrum disorders).

Therapeutic Classes:

  • Gastrointestinal Agent

Forms:

  • Capsule

How it’s taken:

  • By mouth

What is Cholbam used for?

Cholbam is a bile acid that comes in capsule form. It is used to treat Bile Acid Synthesis Disorders and works by normalizing bile acid production in the body. Cholbam works best if you take it with food. Common side effects may include heartburn, acid reflux, nausea, diarrhea, stomach pain and a general ill feeling.

What form(s) does Cholbam come in

  • Capsule

What are common Cholbam doses?

  • Capsule 50MG

How to take Cholbam

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Oral route: It is best to take this medicine with food or milk.

  • Swallow the capsule whole. Do not crush, break, or chew it.

  • If you cannot swallow the capsule, you may open the capsule and mix the contents with 1 to 2 tablespoons of infant formula or breast milk, or soft food (such as mashed potatoes or apple puree). This mixture must be swallowed immediately.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

What to do if you miss a dose of Cholbam

Cholbam contraindications

  • This medicine is generally considered safe for most people. Talk to your doctor if you have concerns.

Cholbam warnings

  • Tell your doctor if you are pregnant or breastfeeding, you have liver disease, or if you or a family member has familial hypertriglyceridemia.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Cholbam interactions

  • Some foods and medicines can affect how cholic acid works. Tell your doctor if you are using cyclosporine.

  • If you are also taking cholestyramine, colesevelam, colestipol, or aluminum-containing antacids, take cholic acid at least 1 hour before or 4 to 6 hours after these medicines.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Cholbam side effects

Serious Side Effects

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes

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