What is Clindamycin: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Clindamycin hydrochloride is a generic prescription antibiotic that treats serious to severe bacterial infections. Clindamycin HCl works by blocking the ability of bacteria to make the proteins they need to survive. Although clindamycin is available in a wide variety of dosage formats, clindamycin HCl can only be taken as capsules. Different versions of clindamycin are found in other dosage formats. Doses are taken four times daily.

Clindamycin overview

BRAND NAMES:

  • Cleocin HCl

Generic Names:

  • Clindamycin Hcl

Uses:

  • Treats infections

Therapeutic Classes:

  • Antibiotic, lincosamide antibiotic

Forms:

  • Capsule

How it’s taken:

  • By mouth

What is Clindamycin used for?

Clindamycin HCl treats serious to severe bacterial infections including respiratory tract infections, soft tissue infections, abdominal infections, pelvic or genital tract infections in women, and septicemia.

What form(s) does Clindamycin come in

  • Capsule

    • 75 mg

    • 150 mg

    • 300 mg

What are common Clindamycin doses?

  • For serious bacterial infections:

    • In adults: 150–300 mg taken orally every six hours

    • In children: 8–16 mg/kg per day divided into three or four doses

  • For severe bacterial infections:

    • In adults: 300–450 mg taken orally every six hours

    • In children: 16–20 mg/kg per day divided into three or four doses

  • Clindamycin HCl is not the first-choice clindamycin treatment. Healthcare professionals may prefer to use or at least start with clindamycin phosphate injections.

  • Because dosages are based on weight, children may not be able to take clindamycin HCl capsules. A healthcare provider may prescribe clindamycin palmitate oral solution for more precise dosing.

Common Clindamycin prescriptions

  • Clindamycin HCl
    16 capsules bottle

  • Clindamycin HCl
    150mg capsule

  • Clindamycin HCl
    300mg capsule

  • Clindamycin HCl
    75mg capsule

How to take Clindamycin

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Take this medicine for the full duration of treatment even if you feel better in the first few days.

  • Store clindamycin capsules at room temperature in a closed, light-resistant container.

What to do if you miss a dose of Clindamycin

  • Take a missed dose when remembered.

  • If it’s almost time for the next dose, skip the missed dose and take the next dose as scheduled.

  • Do not take extra capsules to make up for a missed dose.

Clindamycin contraindications

  • This medicine is not right for everyone. 

  • Do not use it if you have had an allergic reaction to clindamycin or lincomycin.

Clindamycin warnings

  • Tell any healthcare provider or other healthcare provider who treats you that you are on clindamycin. 

  • Regular doctor visits are necessary to check if clindamycin treatment is working. Keep all appointments.

  • Tell the prescriber if you are pregnant, breastfeeding, or have: 

    • Kidney problems

    • Digestive system problems, especially a history of colitis

    • Allergies

  • Clindamycin HCl can cause severe allergic reactions or skin reactions.

  • This medicine can cause diarrhea up to two months after treatment ends. Contact a healthcare professional if you experience severe, continual, watery, or bloody diarrhea. Do not take any medicine to stop diarrhea until you have talked to a doctor.

  • Clindamycin HCl might cause kidney damage.

Clindamycin interactions

  • Some medicines can affect how clindamycin works. Tell your doctor if you are using erythromycin.

  • Clindamycin has very few major drug interactions. To avoid potentially hazardous drug interactions, tell the prescribing healthcare provider about all prescription drugs, over-the-counter medications, and supplements you use.

  • Tell any other prescriber who treats you that you are taking clindamycin HCl capsules before they put you on a new medicine. 

  • Clindamycin could interfere with medicines that other doctors and healthcare professionals use, including:

    • Nerve blocks

    • Bowel preparation regimens before a colonoscopy

    • Bacterial vaccines

Find more detailed information about clindamycin interactions to avoid here.

Clindamycin side effects

Serious side effects

The most serious side effects of clindamycin HCl are allergic reactions, drug reactions, kidney injury, and C. difficile diarrhea. Talk to a doctor if you notice any signs or symptoms of a possible serious side effect, including:

  • Severe diarrhea that does not go away, stomach cramps

  • Decreased urination, swelling in the hands, feet, and ankles

  • Itching, hives, or pustules

  • Blistering, peeling, red skin rash

  • Pain when swallowing

  • Swelling in your hands or face, swelling in your mouth or throat

  • Chest tightness, trouble breathing, wheezing

  • Sudden drop in blood pressure, lightheadedness, fainting, trouble thinking

  • Fever, skin rash, swollen neck glands, change in how much or how often you urinate, or bloody or cloudy urine

Less serious side effects

  • Dry mouth

  • Skin redness

  • Diarrhea

  • Itching

  • Yeast infections

Sources:

Subscribe to our savings newsletter

Health education, drug info, wellness & more

By clicking 'Subscribe', I agree to SingleCare's Terms & Conditions.