What is Definity? Uses, warnings & side effects

Updated May 14, 2025  •  Published Dec 30, 2020

Definity overview

BRAND NAMES:

  • Definity, Isovue-200, Isovue-250, Isovue-300, Isovue-370, Isovue-M 200, Isovue-M 300, Isovue Multipack-250, Isovue Multipack-300, Isovue Multipack-370, Omnipaque 140, Omnipaque 180, Omnipaque 240, Omnipaque 300, Omnipaque 350, Definity

Generic Names:

  • Definity

Uses:

  • Helps parts of your body show up better during imaging tests., Used during an echocardiogram to help show the inside of your heart.

Therapeutic Classes:

  • Diagnostic Agent, Radiological Contrast Media, Radiological Ionic Contrast Media, Radiological Non-Ionic Contrast Media, Radiological Non-Ionic Contrast Media

Forms:

  • Injectable, Injectable

How it’s taken:

  • By injection, By injection

What is Definity used for?

What form(s) does Definity come in?

  • Injectable

  • Injectable

What are common Definity dosages?

  • Vial 2ML of 6.52MG/ML

Definity images - What does Definity look like?

  • Definity
    2ml of 6.52mg/ml vial

How to take Definity

  • Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.

  • Injection routeA nurse or other health provider will give you this medicine.

  • Injection routeA nurse or other health provider will give you this medicine.

  • Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.

  • Injection routeA nurse or other health provider will give you this medicine. It is given through a needle placed in an artery or a vein.

  • Injection routeA nurse or other health provider will give you this medicine. It is given through a needle placed in an artery or a vein.

What to do if you miss a dose of Definity

Definity contraindications - Who shouldn't take Definity?

  • This medicine is not right for everyone. You should not receive it if you had an allergic reaction to perflutren.

  • This medicine is not right for everyone. You should not receive it if you had an allergic reaction to any contrast dye.

Definity warnings

  • Tell your doctor if you are pregnant or breastfeeding, or if you have heart failure, heart rhythm problems, a history of heart attack, or lung disease.

  • This medicine could cause changes to your heart rhythm.

  • Fast, slow, or uneven heartbeat

  • Lightheadedness or fainting

  • Seizures

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart or blood vessel problems, heart failure, a blood disorder (including anemia or sickle cell disease), diabetes, lung disease, thyroid problems, multiple sclerosis, pheochromocytoma, or multiple myeloma. Tell your doctor if you have a history of stroke, heart attack, or seizures. Tell your doctor if you have asthma, hay fever, or an allergy to any food or iodine.

  • This medicine may cause the following problems: Kidney problemsBlood clotting problemsChanges in heart rhythm

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • Fast, slow, or uneven heartbeat

  • Lightheadedness, dizziness, fainting

  • Muscle stiffness or weakness, stiff joints or trouble moving, bone pain

  • Numbness or weakness on one side of your body, pain in your lower leg (calf)

  • Pain, itching, burning, redness, swelling, or a lump under your skin where the needle is placed

  • Skin rash, swelling, hardness, tightness, burning, or itching, red or dark patches

  • Sudden or severe headache, problems with vision, speech, or walking

Definity interactions & what to avoid when taking Definity

  • There are many medicines that can interact with a contrast dye. Make sure your doctor knows the names of all the medicines you use, especially metformin or a beta-blocker medicine.

  • Tell your doctor if you have recently received any other contrast dyes or medicines.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • Tell your doctor if you are pregnant or breastfeeding, or if you have a congenital heart defect or heart or lung condition, such as heart failure, heart rhythm problems, a history of heart attack, or lung disease.

  • This medicine could cause changes to your heart rhythm.

Definity side effects - How does Definity make you feel?

Serious Side Effects

  • Sudden or severe headache, problems with vision, speech, or walking

  • Chest pain, trouble breathing, coughing up blood

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Decrease in how much or how often you urinate, bloody or cloudy urine, lower back or side pain

  • Fast, slow, or uneven heartbeat

  • Numbness or weakness on one side of your body, pain in your lower leg (calf)

  • Muscle stiffness or weakness, stiff joints or trouble moving, bone pain

  • Skin rash, swelling, hardness, tightness, burning, or itching, red or dark patches

  • Pain, itching, burning, redness, swelling, or a lump under your skin where the needle is placed

  • Lightheadedness, dizziness, fainting

  • Seizures

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Chest pain or trouble breathing

  • Fast, slow, pounding, or uneven heartbeat

  • Lightheadedness, dizziness, or fainting

Less Serious Side Effects

  • Warmth or redness in your face, neck, arms, or upper chest

  • Pain, itching, burning, swelling, or a lump under your skin where the needle is placed

  • Pain, itching, burning, swelling, or a lump under your skin where the needle is placed

  • Dizziness or headache

  • Headache

  • Warmth or redness in your face, neck, arms, or upper chest

  • Nausea, vomiting

  • Mild feeling of burning, warmth, coldness when the medicine is injected

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