Deplin 15 Coupons & Prices

Deplin 15 is a Dietary Management Product Combinations class medication produced by Alfasigma Usa. Deplin 15 is classified as a prescription medical food. Deplin 15 is used together with medications to treat adults with either depression or schizophrenia who also have low levomefolate (a type of vitamin B) levels. It is not an antidepressant or antipsychotic medicine, but it helps these medicines work better. The average retail price of Deplin 15 is $275.09 per 30, 15-90.314mg capsules, but you can pay just $101.24 for 30, 15-90.314mg capsules of Deplin 15 with a SingleCare prescription drug discount card. Deplin 15 is a brand-name drug.

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Deplin 15 coupon at Kroger Pharmacy
$104.24
$ 101.24
$3 off with signupwith signup

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Deplin 15 coupon at Harris Teeter Pharmacy
$104.24
$ 101.24
$3 off with signupwith signup

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Deplin 15 coupon at Walmart Neighborhood Market Pharmacy
$112.06
$ 109.06
$3 off with signupwith signup
Deplin 15 coupon at Walmart Pharmacy
$112.06
$ 109.06
$3 off with signupwith signup
Deplin 15 coupon at Publix Pharmacy
$113.94
$ 110.94
$3 off with signupwith signup
Deplin 15 coupon at Walgreens Pharmacy
$114.21
$ 111.21
$3 off with signupwith signup
$ 111.50
$ 119.38
$126.82
$ 123.82
$3 off with signupwith signup

About SingleCare Pricing

SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.

Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.

Prices updated: 12/05/2025

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About Deplin 15

Deplin 15 is a Dietary Management Product Combinations class medication produced by Alfasigma Usa. Deplin 15 is classified as a prescription medical food. Deplin 15 is used together with medications to treat adults with either depression or schizophrenia who also have low levomefolate (a type of vitamin B) levels. It is not an antidepressant or antipsychotic medicine, but it helps these medicines work better. The average retail price of Deplin 15 is $275.09 per 30, 15-90.314mg capsules, but you can pay just $101.24 for 30, 15-90.314mg capsules of Deplin 15 with a SingleCare prescription drug discount card. Deplin 15 is a brand-name drug.

About Deplin 15

Deplin 15 is a Dietary Management Product Combinations class medication produced by Alfasigma Usa. Deplin 15 is classified as a prescription medical food. Deplin 15 is used together with medications to treat adults with either depression or schizophrenia who also have low levomefolate (a type of vitamin B) levels. It is not an antidepressant or antipsychotic medicine, but it helps these medicines work better. The average retail price of Deplin 15 is $275.09 per 30, 15-90.314mg capsules, but you can pay just $101.24 for 30, 15-90.314mg capsules of Deplin 15 with a SingleCare prescription drug discount card. Deplin 15 is a brand-name drug.

Deplin 15 FAQs

How much does Deplin 15 cost without insurance?

The standard out-of-pocket cost of Deplin 15 without health insurance is $275.09 per 30, 15-90.314mg capsules though you can save using a SingleCare Deplin 15 coupon to pay only $101.24 for 30, 15-90.314mg capsules of Deplin 15. Customers who do not have access to an insurance plan can still use a coupon from SingleCare’s discount program for free Deplin 15 savings. All you need to do is present a valid prescription at a participating pharmacy—there are no other eligibility requirements. 

How much does Deplin 15 cost with insurance?

Each insurance formulary is different and may or may not cover Deplin 15. The cost of Deplin 15 with insurance coverage varies depending on your plan - check with your insurance provider for specific drug coverage and copay details. If your insurance does not cover Deplin 15, you can use SingleCare to get discounts on Deplin 15 at your participating pharmacy. Additionally, you can also use SingleCare coupons if you have Medicare or Medicaid. If Medicare or Medicaid don’t cover your Deplin 15 prescription, you can use SingleCare instead. Go to the SingleCare website or app to compare the lowest price of Deplin 15 with SingleCare versus your copay with insurance or Medicare.

Does Medicare cover Deplin 15, and how much does it cost?

Deplin 15 is generally not covered by Medicare prescription plans. You can refer to your plan’s drug formulary to determine whether your Medicare Part D or Medicare Advantage plan covers Deplin 15 and how much the copay or coinsurance is. If Deplin 15 is not covered by Medicare, you may have to pay the full price of $275.09 for 30, 15-90.314mg capsules. In that case, using a SingleCare coupon for Deplin 15 could save you more money than Medicare. Our lowest price for Deplin 15 is currently $101.24 for 30, 15-90.314mg capsules.

Is there a generic of Deplin 15?

Deplin 15 is a brand name drug made by Alfasigma Usa. The generic version of Deplin 15 is L-Methylfolate-Algae and is much cheaper than the price of Deplin 15, which is $275.09 per 30, 15-90.314mg capsules, but uses the same active ingredient as Deplin 15. Use a SingleCare prescription drug discount card to pay $101.24 for 30, 15-90.314mg capsules.

What is Deplin 15? 

Deplin 15 is classified as a prescription medical food. It can be used in combination with medications to treat depression in people with low levomefolate levels. It can also be used in combination with medications to treat schizophrenia in people with low levomefolate levels. Deplin 15 is not an antidepressant or antipsychotic drug, but helps these types of medicines work better.

Deplin 15 is available as a capsule that is taken by mouth once daily.

What are the side effects of Deplin 15?

Common side effects of Deplin 15 include stomach problems like nausea, vomiting, diarrhea, or stomach cramps. It can also cause altered sleep patterns, vivid dreams, confusion, irritability, rash, and overactivity. 

People with symptoms of an allergic reaction such as hives, difficulty breathing, or swelling of the face, lips, tongue, or throat, should get emergency medical help. 

How does Deplin 15 help with anxiety?

Deplin 15 contains a form of folate, a B vitamin that helps improve the mood. People with depression may have low levels of folate, so taking this medication can help you see results from an antidepressant medicine. 

Are there any known interactions with Deplin 15? 

Before taking Deplin 15, tell your physician about all the medications you take including prescription and OTC medicines, vitamins, and supplements. Deplin 15 interacts with cholestyramine and colestipol. If you take either of these medications, your healthcare provider will likely advise you to take Deplin 15 at least one hour before or four hours after cholestyramine or colestipol. Deplin 15 can also interact with other drugs, such as capecitabine or methotrexate. Ask your healthcare provider about drug interactions and how they may affect you. 

Are there any known contraindications with Deplin 15? 

Anyone allergic to levomefolate or any ingredient in this medicine should not take Deplin 15. Tell your healthcare provider if you have (or have a history of) anemia or B12 deficiency.

What can I take instead of Deplin 15? 

Patients interested in an alternative to Deplin 15 can consult their healthcare provider for more information and medical advice. Only your healthcare provider can determine the appropriate treatment for you based on your medical history. 

Where are Deplin 15 coupons from SingleCare accepted?

SingleCare is accepted at most national pharmacies and grocers, including the following:

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