Deplin 15 is a Dietary Management Product Combinations class medication produced by Alfasigma Usa. Deplin 15 is classified as a prescription medical food. Deplin 15 is used together with medications to treat adults with either depression or schizophrenia who also have low levomefolate (a type of vitamin B) levels. It is not an antidepressant or antipsychotic medicine, but it helps these medicines work better. The average retail price of Deplin 15 is $282.59 per 30, 15-90.314mg capsules, but you can pay just $101.24 for 30, 15-90.314mg capsules of Deplin 15 with a SingleCare prescription drug discount card. Deplin 15 is a brand-name drug.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
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Prices updated: 05/04/2026
Deplin 15 is a Dietary Management Product Combinations class medication produced by Alfasigma Usa. Deplin 15 is classified as a prescription medical food. Deplin 15 is used together with medications to treat adults with either depression or schizophrenia who also have low levomefolate (a type of vitamin B) levels. It is not an antidepressant or antipsychotic medicine, but it helps these medicines work better. The average retail price of Deplin 15 is $282.59 per 30, 15-90.314mg capsules, but you can pay just $101.24 for 30, 15-90.314mg capsules of Deplin 15 with a SingleCare prescription drug discount card. Deplin 15 is a brand-name drug.
Deplin 15 is a Dietary Management Product Combinations class medication produced by Alfasigma Usa. Deplin 15 is classified as a prescription medical food. Deplin 15 is used together with medications to treat adults with either depression or schizophrenia who also have low levomefolate (a type of vitamin B) levels. It is not an antidepressant or antipsychotic medicine, but it helps these medicines work better. The average retail price of Deplin 15 is $282.59 per 30, 15-90.314mg capsules, but you can pay just $101.24 for 30, 15-90.314mg capsules of Deplin 15 with a SingleCare prescription drug discount card. Deplin 15 is a brand-name drug.
The standard out-of-pocket cost of Deplin 15 without health insurance is $282.59 per 30, 15-90.314mg capsules though you can save using a SingleCare Deplin 15 coupon to pay only $101.24 for 30, 15-90.314mg capsules of Deplin 15. Customers who do not have access to an insurance plan can still use a coupon from SingleCare’s discount program for free Deplin 15 savings. All you need to do is present a valid prescription at a participating pharmacy—there are no other eligibility requirements.
Each insurance formulary is different and may or may not cover Deplin 15. The cost of Deplin 15 with insurance coverage varies depending on your plan - check with your insurance provider for specific drug coverage and copay details. If your insurance does not cover Deplin 15, you can use SingleCare to get discounts on Deplin 15 at your participating pharmacy. Additionally, you can also use SingleCare coupons if you have Medicare or Medicaid. If Medicare or Medicaid don’t cover your Deplin 15 prescription, you can use SingleCare instead. Go to the SingleCare website or app to compare the lowest price of Deplin 15 with SingleCare versus your copay with insurance or Medicare.
Deplin 15 is generally not covered by Medicare prescription plans. You can refer to your plan’s drug formulary to determine whether your Medicare Part D or Medicare Advantage plan covers Deplin 15 and how much the copay or coinsurance is. If Deplin 15 is not covered by Medicare, you may have to pay the full price of $282.59 for 30, 15-90.314mg capsules. In that case, using a SingleCare coupon for Deplin 15 could save you more money than Medicare. Our lowest price for Deplin 15 is currently $101.24 for 30, 15-90.314mg capsules.
Deplin 15 is a brand name drug made by Alfasigma Usa. The generic version of Deplin 15 is L-Methylfolate-Algae and is much cheaper than the price of Deplin 15, which is $282.59 per 30, 15-90.314mg capsules, but uses the same active ingredient as Deplin 15. Use a SingleCare prescription drug discount card to pay $101.24 for 30, 15-90.314mg capsules.
Deplin 15 is classified as a prescription medical food. It can be used in combination with medications to treat depression in people with low levomefolate levels. It can also be used in combination with medications to treat schizophrenia in people with low levomefolate levels. Deplin 15 is not an antidepressant or antipsychotic drug, but helps these types of medicines work better.
Deplin 15 is available as a capsule that is taken by mouth once daily.
Common side effects of Deplin 15 include stomach problems like nausea, vomiting, diarrhea, or stomach cramps. It can also cause altered sleep patterns, vivid dreams, confusion, irritability, rash, and overactivity.
People with symptoms of an allergic reaction such as hives, difficulty breathing, or swelling of the face, lips, tongue, or throat, should get emergency medical help.
Deplin 15 contains a form of folate, a B vitamin that helps improve the mood. People with depression may have low levels of folate, so taking this medication can help you see results from an antidepressant medicine.
Before taking Deplin 15, tell your physician about all the medications you take including prescription and OTC medicines, vitamins, and supplements. Deplin 15 interacts with cholestyramine and colestipol. If you take either of these medications, your healthcare provider will likely advise you to take Deplin 15 at least one hour before or four hours after cholestyramine or colestipol. Deplin 15 can also interact with other drugs, such as capecitabine or methotrexate. Ask your healthcare provider about drug interactions and how they may affect you.
Anyone allergic to levomefolate or any ingredient in this medicine should not take Deplin 15. Tell your healthcare provider if you have (or have a history of) anemia or B12 deficiency.
Patients interested in an alternative to Deplin 15 can consult their healthcare provider for more information and medical advice. Only your healthcare provider can determine the appropriate treatment for you based on your medical history.
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SingleCare is a prescription discount service that offers free coupons on thousands of prescription drugs. It can be used whether you have insurance, Medicare, Medicaid, or none of the above, but it cannot be combined with insurance.
SingleCare provides transparent drug pricing, so you can compare discounts at pharmacies near you. Browse singlecare.com to find drug discounts, helpful information about your prescription, and resources to help you make informed health decisions.
Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2026 SingleCare Administrators. All rights reserved