Nucynta (tapentadol) is a narcotic prescription medication used for severe pain. It’s a controlled substance that requires a prescription from a healthcare professional. Your healthcare provider may prescribe Nucynta to relieve acute, severe pain requiring strong relief. There is no generic version of this brand-name drug. Nucynta costs $446.64 for 30, 50mg tablets of Nucynta without insurance or discounts. If you are uninsured or underinsured, you may use a free Nucynta coupon from SingleCare to reduce your medication cost to $322.15 for 30, 50mg tablets of Nucynta.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
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Prices updated: 12/05/2025
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Nucynta (tapentadol) is a narcotic prescription medication used for severe pain. It’s a controlled substance that requires a prescription from a healthcare professional. Your healthcare provider may prescribe Nucynta to relieve acute, severe pain requiring strong relief. There is no generic version of this brand-name drug. Nucynta costs $446.64 for 30, 50mg tablets of Nucynta without insurance or discounts. If you are uninsured or underinsured, you may use a free Nucynta coupon from SingleCare to reduce your medication cost to $322.15 for 30, 50mg tablets of Nucynta.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Nucynta Retail Price | Nucynta SingleCare Price |
|---|---|---|
| CVS Pharmacy | $431.40 | $383.40 |
| Walgreens | $441.30 | $387.90 |
| Kroger Pharmacy | $438.30 | $313.50 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Nucynta (tapentadol) is a narcotic prescription medication used for severe pain. It’s a controlled substance that requires a prescription from a healthcare professional. Your healthcare provider may prescribe Nucynta to relieve acute, severe pain requiring strong relief. There is no generic version of this brand-name drug. Nucynta costs $446.64 for 30, 50mg tablets of Nucynta without insurance or discounts. If you are uninsured or underinsured, you may use a free Nucynta coupon from SingleCare to reduce your medication cost to $322.15 for 30, 50mg tablets of Nucynta.
The average Nucynta retail price without health insurance is $446.64 for 30, 50mg tablets. People without insurance can use a SingleCare savings card for a discounted price of $322.15 for 30, 50mg tablets. Access the SingleCare website and start saving right away.
Insurance copays for Nucynta vary. Your insurance plan may not cover brand-name pain medicines or may charge a high copay. You can ask your healthcare provider for an alternative to Nucynta—or use our prescription discount card to pay only $322.15 for 30, 50mg tablets of Nucynta. Contact your insurance company for up-to-date coverage information.
Medicare drug benefit plans do not typically cover Nucynta. Ask a pharmacist or consult your insurance provider if there is an alternative to Nucynta that Medicare covers. If so, you can ask your healthcare provider to issue a new prescription. If not, you can always use a free SingleCare savings card to get maximum savings of up to 80% off the cost of your prescription. Currently, our lowest price for Nucynta is $322.15 for 30, 50mg tablets.
Nucynta is a brand-name drug containing tapentadol. However, Nucynta is not currently available in generic form. You can use our free Nucynta discount card to reduce prescription costs by up to 80% when you purchase this medication at a participating local pharmacy.
Nucynta is a narcotic (opioid) analgesic tablet used to relieve severe pain. It works by altering your body’s perception of pain and response to pain. It may be prescribed to individuals with severe pain that won’t respond to a milder pain reliever.
Nucynta tablets are available in strengths of 50 mg, 75 mg, and 100 mg. It’s also available in an extended-release form called Nucynta ER. Follow your healthcare provider's instructions for dosage and use of this medication.
Nucynta’s most common side effects include nausea, vomiting, drowsiness, headache, constipation, dizziness, sleepiness, and dry mouth.
Serious side effects may occur. Possible serious side effects include seizures, hallucinations, severe GI problems, and others. Seek immediate medical help if you experience any of these adverse reactions. Also, if you have symptoms of a serious allergic reaction, like hives, trouble breathing, or swelling of the face, lips, tongue, or throat, get emergency medical attention.
As a controlled substance, this pain medication also has the potential to become habit-forming.
This is not a full list of side effects, and others may occur. Consult your healthcare provider for additional information or questions about side effects.
Before taking Nucynta, tell your doctor about any allergies to medication, as well as your family history and medical history. People who are allergic to tapentadol or any type of opioids, or any ingredient in Nucynta should not take this medicine. Other individuals who should not take Nucynta include:
People who have taken an MAOI drug in the past 14 days
People with severe kidney or liver problems
People with acute or severe asthma
People with severe respiratory depression, in a coma, in circulatory shock, or with impaired consciousness
People with a known or suspected obstruction in the stomach or intestines, or bowel problems
The shelf life of Nucynta will vary, so ask your pharmacist when it expires and how to dispose of it at the nearest drug take-back location. Because Nucynta has the potential for abuse and dependence, you should store it where no one can get to it and keep track of your pills so you know if any are missing. Even taking one pill, especially by a child, can cause death.
The best alternative for Nucynta depends on various individual factors like the severity of your pain, other medications you take, potential side effects, and more. Your doctor will consider what kind of pain control you need and prescribe the appropriate medication(s). This could be a different opioid pain medicine or something less strong, like a nonsteroidal anti-inflammatory drug such as Mobic (meloxicam) or Celebrex (celecoxib). Consult your healthcare provider for medical advice.
After receiving her doctorate from the University of Pittsburgh School of Pharmacy, Karen Berger, Pharm.D., has worked in both chain and independent community pharmacies. She currently works at an independent pharmacy in New Jersey. Dr. Berger enjoys helping patients understand medical conditions and medications—both in person as a pharmacist, and online as a medical writer and reviewer.
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Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved