What is Doxorubicin: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Doxorubicin overview

BRAND NAMES:

  • Adriamycin, Adriamycin Novaplus, PremierPro Rx DOXOrubicin HCl

Generic Names:

  • Doxorubicin Hcl

Uses:

  • Treats cancer.

Therapeutic Classes:

  • Antineoplastic Agent

Forms:

  • Injectable

How it’s taken:

  • By injection

What is Doxorubicin used for?

Adriamycin comes in an injectable form and is used to treat several types of cancer including breast, bone, stomach and lung. It works by interfering with the growth and spread of cancer cells in the body.

What form(s) does Doxorubicin come in

  • Injectable

What are common Doxorubicin doses?

  • Vial 5ML of 2MG/ML

  • Vial 10ML of 2MG/ML

  • Vial 25ML of 2MG/ML

  • Vial 100ML of 2MG/ML

Common Doxorubicin prescriptions

  • DOXOrubicin HCl
    10mg solution reconstituted

  • DOXOrubicin HCl
    50mg solution reconstituted

  • DOXOrubicin HCl
    100ml of 2mg/ml vial

  • DOXOrubicin HCl
    10ml of 2mg/ml vial

  • DOXOrubicin HCl
    25ml of 2mg/ml vial

  • DOXOrubicin HCl
    5ml of 2mg/ml vial

  • DOXOrubicin HCl
    75ml of 2mg/ml vial

How to take Doxorubicin

  • Do not get the medicine on your skin. If it does, wash the area well with soap and water, and tell your caregiver.

  • If you feel stinging or burning in your skin where the needle is placed, tell your caregiver right away. Apply ice to the skin for 15 minutes, 4 times each day, to relieve pain or swelling, Do this for 3 days. Tell your doctor if you have blisters, sores, or other skin changes where the needle was placed.

  • Drink extra fluids so you will urinate more often and help prevent kidney problems.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Injection routeThis medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

  • Injection routeMedicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

  • Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.

  • Injection routeYou will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.

  • The medicine is usually given once every 21 to 28 days.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Drink extra fluids so you will urinate more often and help prevent kidney problems.

  • The medicine is usually given once every 21 to 28 days.

  • If you feel stinging or burning in your skin where the needle is placed, tell your caregiver right away. Apply ice to the skin for 15 minutes, 4 times each day, to relieve pain or swelling, Do this for 3 days. Tell your doctor if you have blisters, sores, or other skin changes where the needle was placed.

  • Injection routeYou will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.

  • Injection routeThis medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

  • Do not get the medicine on your skin. If it does, wash the area well with soap and water, and tell your caregiver.

  • Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.

  • Injection routeMedicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

What to do if you miss a dose of Doxorubicin

Doxorubicin contraindications

  • This medicine is not right for everyone. You should not receive this medicine if you had an allergic reaction to doxorubicin, are pregnant, or have had a recent heart attack.

Doxorubicin warnings

  • Injection routeThis medicine may cause birth defects if either partner is using it during conception or pregnancy. Tell your doctor right away if you or your partner becomes pregnant. Use an effective form of birth control during treatment and for 6 months after the last dose of this medicine.

  • Tell your doctor if you are breastfeeding, or if you have liver disease, heart disease, or blood or bone marrow problems (myelosuppression). Tell your doctor if you have received other cancer medicine or radiation treatment.

  • This medicine may cause the following problems:Heart damage, including heart failure (may be permanent)Heart rhythm problemHigher risk of new cancersSkin damage near the injection siteTumor lysis syndrome

  • Oral routeThis medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children. This medicine may also cause premature menopause.

  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Unusual bleeding, bruising, or weakness

Doxorubicin interactions

  • Some foods and medicines can affect how doxorubicin works. Tell your doctor if you are also using any of the following:St John's wortMercaptopurineCyclophosphamide, paclitaxel, , trastuzumabPhenobarbital, phenytoinVerapamil

  • Tell your doctor if you are breastfeeding, or if you have liver disease, heart disease, or blood or bone marrow problems (myelosuppression). Tell your doctor if you have received other cancer medicine or radiation treatment.

  • This medicine may cause the following problems:Heart damage, including heart failure (may be permanent)Heart rhythm problemHigher risk of new cancersSkin damage near the injection siteTumor lysis syndrome

  • Oral routeThis medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children. This medicine may also cause premature menopause.

  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Doxorubicin side effects

Serious Side Effects

  • Unusual bleeding, bruising, or weakness

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Chest pain

  • Fast, pounding, or uneven heartbeat

  • Fever, chills, cough, sore throat, and body aches

  • Severe nausea, mouth sores, diarrhea, or uncontrollable vomiting

  • Rapid weight gain, swelling in your hands, ankles, or feet, trouble breathing, tiredness

Less Serious Side Effects

  • Hair loss

  • Changes in menstrual periods

  • Red urine for 1 to 2 days after treatment

  • Mild nausea, vomiting, diarrhea, mouth sores

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