What is Empliciti: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Empliciti overview

BRAND NAMES:

  • Empliciti

Generic Names:

  • Empliciti

Uses:

  • Treats multiple myeloma.

Therapeutic Classes:

  • Antineoplastic Agent

Forms:

  • Injectable

How it’s taken:

  • By injection

What is Empliciti used for?

Empliciti is used in combination with lenalidomide and dexamethasone to treat patients with multiple myeloma who have had at least 1 to 3 prior treatments. It triggers a special kind of immune cell known as the natural killer cell. Empliciti identifies myeloma cells so that natural killer cells can destroy them. It indicated for use by adults and is available as an injection.

What form(s) does Empliciti come in

  • Injectable

What are common Empliciti doses?

  • Solution Reconstituted 400MG

Common Empliciti prescriptions

  • Empliciti
    300mg solution reconstituted

  • Empliciti
    400mg solution reconstituted

How to take Empliciti

  • Missed dose: Injection routeThis medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Your doctor may give you other medicines (including an allergy medicine, fever medicine, stomach medicine, or steroid) 45 to 90 minutes before infusion to prevent unwanted effects.

  • Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.

  • Injection routeYou will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.

  • Your doctor may give you other medicines (including an allergy medicine, fever medicine, stomach medicine, or steroid) 45 to 90 minutes before infusion to prevent unwanted effects.

  • Missed dose: Injection routeThis medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

  • Injection routeYou will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.

  • Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

What to do if you miss a dose of Empliciti

Empliciti contraindications

  • This medicine is not right for everyone. You should not receive it if you had an allergic reaction to elotuzumab.

Empliciti warnings

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • This medicine may cause the following problems:Infusion reactionsIncreased risk of infectionsIncreased risk for other cancers, including skin cancerLiver problems

  • This medicine is used together with lenalidomide and dexamethasone or pomalidomide and dexamethasone. Lenalidomide and pomalidomide can cause birth defects if either partner is using it during pregnancy or conception. Use an effective form of birth control during treatment with this medicine. Tell your doctor right away if you think you have become pregnant.

  • Do not breastfeed during treatment with this medicine.

  • Tell your doctor if you have liver disease or any type of infection.

  • Injection routeMedicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

Empliciti interactions

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • This medicine may cause the following problems:Infusion reactionsIncreased risk of infectionsIncreased risk for other cancers, including skin cancerLiver problems

  • Injection routeMedicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

  • Tell your doctor if you are breastfeeding, or if you have liver disease or any infection.

  • This medicine is used together with lenalidomide and other medicines. Lenalidomide can cause birth defects if either partner is using it during pregnancy or conception. Tell your doctor right away if your or your partner becomes pregnant.

Empliciti side effects

Serious Side Effects

  • Fever, chills, cough, sore throat, body aches

  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes

  • Skin growths or changes

  • Lightheadedness, dizziness, fainting, slow heartbeat

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

Less Serious Side Effects

  • Decreased appetite

  • Pain, itching, burning, swelling, or a lump under your skin where the needle is placed

  • Numbness, tingling, or burning pain in your hands, arms, legs, or feet

  • Diarrhea, constipation

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