What is Endometrin: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 31, 2020

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Endometrin overview

BRAND NAMES:

  • Crinone, Endometrin, First-Progesterone VGS 100

Generic Names:

  • Endometrin

Uses:

  • Increases the amount of progesterone in your body. Used as part of treatment for infertility. Also treats menstrual periods that have stopped before menopause.

Therapeutic Classes:

  • Female Reproductive Agent, Endocrine-Metabolic Agent, Endometrial Hyperplasia Agent

Forms:

  • Gel/Jelly, Suppository, Tablet

How it’s taken:

  • Into the vagina

What is Endometrin used for?

What form(s) does Endometrin come in

  • Gel/Jelly

  • Suppository

  • Tablet

What are common Endometrin doses?

  • Box 21 Insert

  • Insert 100MG

Common Endometrin prescriptions

  • Endometrin
    21 insert box

How to take Endometrin

  • Your doctor will tell you how much medicine to use. Do not use more than directed. Use this medicine only in your vagina. Do not swallow it.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Vaginal routeWash your hands with soap and water before and after using this medicine.

  • Vaginal gel: This medicine comes in a prefilled, disposable applicator. Use each applicator only once, and then throw it away.Vaginal routeThis medicine may leak out of your vagina during the day. You may wear a sanitary pad to protect your clothing, but do not use a tampon. You might see small, white drops of gel up to several days after you insert the medicine.

  • Vaginal tablet:This medicine comes with a disposable applicator. Place the tablet in the applicator and then insert the applicator into your vagina. Use each applicator only once, and then throw it away.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Vaginal gel: This medicine comes in a prefilled, disposable applicator. Use each applicator only once, and then throw it away.Vaginal routeThis medicine may leak out of your vagina during the day. You may wear a sanitary pad to protect your clothing, but do not use a tampon. You might see small, white drops of gel up to several days after you insert the medicine.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Your doctor will tell you how much medicine to use. Do not use more than directed. Use this medicine only in your vagina. Do not swallow it.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Vaginal tablet:This medicine comes with a disposable applicator. Place the tablet in the applicator and then insert the applicator into your vagina. Use each applicator only once, and then throw it away.

  • Vaginal routeWash your hands with soap and water before and after using this medicine.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

What to do if you miss a dose of Endometrin

Endometrin contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to progesterone or if you have a history of liver disease, cancer of the breast or genitals, or blood clots (including stroke or heart attack).

Endometrin warnings

  • Tell your doctor if you are pregnant or breastfeeding, or if you have diabetes, heart disease, migraine headaches, epilepsy, asthma, kidney disease, or a history of depression.

  • This medicine may cause blood clots, which may lead to serious problems such as stroke, embolism, or thrombosis.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Rapid weight gain, swelling in your hands, ankles, or feet

  • Unusual, heavy, or nonstop vaginal bleeding or discharge

Endometrin interactions

  • Vaginal tablet: Vaginal routeAvoid using douches or other vaginal products unless your doctor tells you to.

  • Vaginal gel: Do not use other vaginal medicines within 6 hours of the time you insert the gel.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Endometrin side effects

Serious Side Effects

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Chest pain, trouble breathing, or coughing up blood

  • Depression

  • Numbness or weakness on one side of your body, sudden or severe headache, problems with vision, speech, or walking

  • Rapid weight gain, swelling in your hands, ankles, or feet

  • Unusual, heavy, or nonstop vaginal bleeding or discharge

Less Serious Side Effects

  • Breast pain or tenderness

  • Constipation, nausea, cramps

  • Mild headache

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