Excedrin Extra Strength is a brand-name, over-the-counter pain reliever that combines acetaminophen, aspirin, and caffeine. All are substances that reduce the chemicals that cause pain, fever, or swelling in patients with headache, joint pain, muscle pain, arthritis, or the common cold. Caffeine also blocks pain signals in the brain. Acetaminophen and caffeine are common in a number of generic over-the-counter drugs. Excedrin Extra Strength price averages $8.57, but a SingleCare Excedrin Extra Strength coupon lowers that price down to $5.69 per 10, 250-250-65mg tablets. SingleCare discounts are eligible on over-the-counter products, like Excedrin Extra Strength, when prescribed by a physician.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.
Prices updated: 12/05/2025
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Excedrin Extra Strength is a brand-name, over-the-counter pain reliever that combines acetaminophen, aspirin, and caffeine. All are substances that reduce the chemicals that cause pain, fever, or swelling in patients with headache, joint pain, muscle pain, arthritis, or the common cold. Caffeine also blocks pain signals in the brain. Acetaminophen and caffeine are common in a number of generic over-the-counter drugs. Excedrin Extra Strength price averages $8.57, but a SingleCare Excedrin Extra Strength coupon lowers that price down to $5.69 per 10, 250-250-65mg tablets. SingleCare discounts are eligible on over-the-counter products, like Excedrin Extra Strength, when prescribed by a physician.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
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These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Excedrin Extra Strength is a brand-name, over-the-counter pain reliever that combines acetaminophen, aspirin, and caffeine. All are substances that reduce the chemicals that cause pain, fever, or swelling in patients with headache, joint pain, muscle pain, arthritis, or the common cold. Caffeine also blocks pain signals in the brain. Acetaminophen and caffeine are common in a number of generic over-the-counter drugs. Excedrin Extra Strength price averages $8.57, but a SingleCare Excedrin Extra Strength coupon lowers that price down to $5.69 per 10, 250-250-65mg tablets. SingleCare discounts are eligible on over-the-counter products, like Excedrin Extra Strength, when prescribed by a physician.
On average, the price for Excedrin Extra Strength is $8.57 per 24, 250-250-65mg tablets. Excedrin Extra Strength prices vary by pharmacy, quantity, and dosage. SingleCare discounts are eligible on over-the-counter products prescribed by a doctor. With a prescription and a SingleCare coupon for Excedrin Extra Strength, Excedrin Extra Strength costs only $5.69 for 10, 250-250-65mg tablets.
Excedrin Extra Strength is not covered by prescription drug insurance, so you will always pay full price for Excedrin Extra Strength rather than a copay price. With SingleCare, however, the Excedrin Extra Strength price is only $5.69 if accompanied by a doctor's prescription.
Because Excedrin Extra Strength is an inexpensive over-the-counter pain reliever with many less expensive generic alternatives, neither Medicare Advantage nor Medicare Part D cover Excedrin Extra Strength.
One option for Medicare patients with a prescription for Excedrin Extra Strength is a SingleCare savings card. The cost of Excedrin Extra Strength with a SingleCare discount card is only $5.69 per 10, 250-250-65mg tablets.
Excedrin Extra Strength is a brand-name pain reliever with acetaminophen, aspirin, and caffeine, but there are generic alternatives with the brands Equate, Up & Up, and others, in both tablet and gel capsule form. Search for Excedrin Extra Strength or acetaminophen for information and savings coupons for these medications.
Excedrin Extra Strength is a brand-name, over-the-counter pain relief medication that combines acetaminophen, aspirin, and caffeine. Acetaminophen and aspirin belong to a class of medicines called non-steroidal anti-inflammatory drugs (NSAIDs) that block substances that cause inflammation (swelling) and so relieve the symptoms of inflammation, such as pain and fever. Caffeine reduces inflammation but also acts on the nervous system by blocking pain signals in the brain.
Excedrin Extra Strength provides symptom relief for patients with headache, back pain, joint pain, muscle pain, arthritis, hangover, or the common cold. Excedrin Extra Strength is in a tablet form, but acetaminophen, aspirin, and caffeine are available in a gel capsule form for more rapid absorption.
The Excedrin Extra Strength most common side effects are trouble sleeping, nervousness, heartburn, fever, stomach pain, and nausea. Acetaminophen may cause severe allergic reactions on the skin, such as rash, reddening, and blisters. This is not a complete list of the Excedrin Extra Strength side effects. Consult with your doctor or pharmacist about possible side effects before taking this medicine.
SingleCare is accepted at most national pharmacies and grocers, including the following:
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