Janumet XR, or sitagliptin and extended-release metformin, is a prescription medication that helps control blood sugar (along with diet and exercise) in adults with Type 2 diabetes. Metformin and sitagliptin are the active ingredients in Janumet XR that, when used along with a proper diet and exercise plan, help control blood sugar levels. The average cash price of Janumet XR is $682.83 for 60, 50-1000mg tablet extended release 24 hours. Although a cheaper generic version of Janumet XR is unavailable, you can still use Janumet XR coupons at any participating pharmacy to save money and pay $324.74 for 60, 50-1000mg tablet extended release 24 hours on this medication.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
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Prices updated: 12/18/2025
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Janumet XR, or sitagliptin and extended-release metformin, is a prescription medication that helps control blood sugar (along with diet and exercise) in adults with Type 2 diabetes. Metformin and sitagliptin are the active ingredients in Janumet XR that, when used along with a proper diet and exercise plan, help control blood sugar levels. The average cash price of Janumet XR is $682.83 for 60, 50-1000mg tablet extended release 24 hours. Although a cheaper generic version of Janumet XR is unavailable, you can still use Janumet XR coupons at any participating pharmacy to save money and pay $324.74 for 60, 50-1000mg tablet extended release 24 hours on this medication.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Janumet Xr Retail Price | Janumet Xr SingleCare Price |
|---|---|---|
| CVS Pharmacy | $397.80 | $360.60 |
| Walmart | $396.00 | $352.20 |
| Walgreens | $661.20 | $352.20 |
| Kroger Pharmacy | $396.00 | $327.60 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Janumet XR, or sitagliptin and extended-release metformin, is a prescription medication that helps control blood sugar (along with diet and exercise) in adults with Type 2 diabetes. Metformin and sitagliptin are the active ingredients in Janumet XR that, when used along with a proper diet and exercise plan, help control blood sugar levels. The average cash price of Janumet XR is $682.83 for 60, 50-1000mg tablet extended release 24 hours. Although a cheaper generic version of Janumet XR is unavailable, you can still use Janumet XR coupons at any participating pharmacy to save money and pay $324.74 for 60, 50-1000mg tablet extended release 24 hours on this medication.
Without insurance coverage, the retail price of Janumet XR could be $682.83 for 60, 50-1000mg tablet extended release 24 hours or higher. If you bring a free SingleCare savings card with you when you go to pick up your prescription, you may be able to pay our lowest price of $324.74 for 60, 50-1000mg tablet extended release 24 hours. Janumet XR coupons can be found on the SingleCare website or mobile app and can be used at many pharmacies.
The copay of Janumet XR with insurance is based on your insurance coverage and your insurance plan's drug formulary. You must consult your pharmacist to determine your exact cost for Janumet XR when you use insurance.
You can easily find Janumet XR pricing by searching the SingleCare website or app. Using your SingleCare discount card, Janumet XR costs $324.74 for 60, 50-1000mg tablet extended release 24 hours. SingleCare's free coupons may provide greater value than your insurance coverage.
Even if your out-of-pocket costs with insurance are cheaper today, your SingleCare savings on your next refill could be even better. We're constantly reviewing prescription prices for our customers.
Most Medicare plans cover Janumet XR. Out-of-pocket expenses will vary based on your plan’s formulary. Using SingleCare coupons can make your Janumet XR prescription more affordable when compared to Medicare. For example, you'll only owe $324.74 for 60, 50-1000mg tablet extended release 24 hours when you use our copay card.
Janumet XR is a brand-name drug. Generic Janumet XR has not yet been approved or released in the U.S. While you wait for a cheaper alternative to become available, you can claim SingleCare savings on the brand-name drug at select drugstores. You can always call or visit your local pharmacy to see if our Janumet XR coupons are accepted at that pharmacy's location.
Janumet XR is an FDA-approved prescription drug containing metformin and sitagliptin to improve blood sugar levels in adults diagnosed with Type 2 diabetes. Sitagliptin helps increase the amount of insulin your body produces while reducing the amount of a substance called glucagon. Glucagon, produced in the pancreas, can cause your liver to produce more sugar (glucose). Metformin reduces the amount of sugar your liver releases into your blood, allowing your body to respond to insulin more efficiently. Janumet XR works better with exercise and a balanced diet.
Janumet XR is available as an oral tablet in strengths of 50-500 mg, 50-1000 mg, and 100-1000 mg. In this formulation, sitagliptin is immediate-release, and metformin is extended-release. Janumet XR is usually taken once a day to control blood sugar levels. Your healthcare provider will determine which dosage of Janumet XR is best depending on your condition and other medications you may be taking. Read the full medication guide and follow your healthcare provider’s instructions before taking Janumet XR.
Take Janumet XR once daily with a meal. Do not split, chew, or crush the tablet—swallow it whole. If you take two tablets daily, take them together at the same time.
The most common side effects of Janumet XR are diarrhea, nausea, vomiting, gas, stomach pain, and indigestion. This medication can also induce ovulation, so there is a potential for unintended pregnancy. Discuss with your healthcare provider if this is a concern.
Serious side effects of Janumet XR include inflammation of the pancreas (pancreatitis), kidney damage/failure, heart failure, joint pain, and others. Get immediate medical attention if you experience any of these side effects.
Hypoglycemia (low blood sugar) may occur. It is more likely to occur if you take Janumet XR with insulin or a sulfonylurea drug such as glimepiride, glipizide, or glyburide. Before taking Janumet XR, talk to your healthcare provider about hypoglycemia and blood sugar monitoring.
Allergic reactions are rare. Get emergency medical help if you experience hives, difficulty breathing, or swelling of the face, lips, tongue, or throat.
Severe-life threatening skin reactions have occurred in rare cases. Get emergency medical help if you experience fever, sore throat, burning eyes, skin pain, red or purple rash, or blistering or peeling skin.
Janumet XR has a black box warning, the most serious warning required by the United States Food and Drug Administration (FDA). There have been cases of lactic acidosis (a buildup of lactic acid in the bloodstream) associated with metformin, an ingredient in Janumet XR. These cases have resulted in serious illness and death. Symptoms may include malaise (feeling unwell), muscle pain, difficulty breathing, sleepiness, dizziness, coldness, and stomach pain. A diagnosis of lactic acidosis will require hemodialysis, as well as stopping the medication. Certain people at higher risk, including:
Adults 65 years and older
People with kidney problems
People who take certain medications
People who are undergoing certain radiology studies, surgery, or other procedures
People who drink excess alcohol
People with liver problems
This is not a full list of side effects, and others may occur. Consult your healthcare provider for questions and more information about side effects.
Janumet XR contains metformin as one of its two ingredients, so by taking Janumet XR, you are already taking metformin. Ask your healthcare provider if you have any questions about how to take your medication.
After receiving her doctorate from the University of Pittsburgh School of Pharmacy, Karen Berger, Pharm.D., has worked in both chain and independent community pharmacies. She currently works at an independent pharmacy in New Jersey. Dr. Berger enjoys helping patients understand medical conditions and medications—both in person as a pharmacist, and online as a medical writer and reviewer.
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SingleCare is a prescription discount service that offers free coupons on thousands of prescription drugs. It can be used whether you have insurance, Medicare, Medicaid, or none of the above, but it cannot be combined with insurance.
SingleCare provides transparent drug pricing, so you can compare discounts at pharmacies near you. Browse singlecare.com to find drug discounts, helpful information about your prescription, and resources to help you make informed health decisions.
Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved