What is Ezetimibe-Simvastatin: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

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Ezetimibe-Simvastatin overview

BRAND NAMES:

  • Vytorin

Generic Names:

  • Ezetimibe-Simvastatin

Uses:

  • Lowers high cholesterol and triglyceride levels. May reduce the risk of heart attack, stroke, and blood vessel problems. This is a combination of a cholesterol absorption inhibitor and a statin.

Therapeutic Classes:

  • Antihyperlipidemic

Forms:

  • Tablet

How it’s taken:

  • By mouth

What is Ezetimibe-Simvastatin used for?

Ezetimibe-Simvastatin is used with diet and exercise to lower cholesterol levels. It is also used to treat heterozygous high cholesterol and familial homozygous high cholesterol. It contains of ezetimibe and simvastatin. They work together to increase the levels of high-density lipoprotein and decrease the levels of low-density lipoprotein and fat in the blood. Lowering high cholesterol levels reduces the risk of stroke and heart attack in people who have heart disease. It is indicated for use in adults and children 10 years old and older. This medication is available as a tablet.

What form(s) does Ezetimibe-Simvastatin come in

  • Tablet

What are common Ezetimibe-Simvastatin doses?

  • Tablet 10-10MG

  • Tablet 10-80MG

  • Tablet 10-40MG

  • Tablet 10-20MG

Common Ezetimibe-Simvastatin prescriptions

  • Ezetimibe-Simvastatin
    10-10mg tablet

  • Ezetimibe-Simvastatin
    10-20mg tablet

  • Ezetimibe-Simvastatin
    10-40mg tablet

  • Ezetimibe-Simvastatin
    10-80mg tablet

How to take Ezetimibe-Simvastatin

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Take the medicine in the evening, unless your doctor tells you otherwise.

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Take the medicine in the evening, unless your doctor tells you otherwise.

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

What to do if you miss a dose of Ezetimibe-Simvastatin

Ezetimibe-Simvastatin contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to ezetimibe or simvastatin, you are pregnant or breastfeeding, or you have active liver disease.

Ezetimibe-Simvastatin warnings

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.

  • Tell your doctor if you have kidney disease, diabetes, low blood pressure, seizures, thyroid disease, or a history of stroke or heart disease. Tell your doctor if you drink alcohol regularly or have a history of liver disease.

  • This medicine may cause the following problems: Severe muscle problems (including myopathy, immune-mediated necrotizing myopathy), especially when used with other medicinesRhabdomyolysis (severe muscle weakness) that could lead to kidney damageLiver problems

  • Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Ezetimibe-Simvastatin interactions

  • Do not use this medicine together with boceprevir, clarithromycin, cobicistat-containing medicines, cyclosporine, danazol, erythromycin, gemfibrozil, itraconazole, ketoconazole, nefazodone, posaconazole, telaprevir, telithromycin, voriconazole, or certain medicines to treat HIV/AIDS.

  • Some medicines can affect how this medicine works. Tell your doctor if you are using any of the following:Amiodarone, cholestyramine, colchicine, daptomycin, digoxin, dronedarone, fenofibrate, fenofibric acid, lomitapide, niacin (vitamin B3), ranolazineBlood pressure medicine (including amlodipine, diltiazem, verapamil)Blood thinner (including warfarin)Fibrate medicine

  • Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

  • Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Ezetimibe-Simvastatin side effects

Serious Side Effects

  • Unusual tiredness

  • Blistering, peeling, or red skin rash

  • Muscle pain, tenderness, or weakness

  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

Less Serious Side Effects

  • Headache

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