What is Ferrous Gluconate: Uses, Warnings & Interactions

Updated Jul 29, 2025  •  Published Dec 30, 2020

Ferrous gluconate is a common ingredient in prescription and over-the-counter iron supplements. Though iron supplements are not always necessary, they can help people avoid or treat low iron levels. Ferrous gluconate is an iron salt. It is readily absorbed in the gut but can cause gastrointestinal problems. Most crucially, iron supplements can make many prescription drugs less effective.

Ferrous Gluconate overview

BRAND NAMES:

  • Ferate, Fergon, Ferralet

Generic Names:

  • Ferrous gluconate

Uses:

  • Prevents or treats iron deficiency or iron deficiency anemia

Therapeutic Classes:

  • Iron supplement, nutritive agent

Forms:

  • Tablet, liquid

How it’s taken:

  • By mouth

What is Ferrous Gluconate used for?

People use ferrous gluconate supplements to ensure adequate daily iron intake or meet increased iron needs. Healthcare professionals prescribe higher-dose ferrous gluconate supplements to treat or prevent iron deficiency and anemia, or to meet the increased iron needs of pregnancy or other medical conditions.

What form(s) does Ferrous Gluconate come in

  • Healthcare providers usually indicate the dosage strength of ferrous gluconate products based on the amount of elemental iron per dose.

  • Most ferrous gluconate products list the elemental iron dose on the package, but some also list the elemental iron and ferrous gluconate amounts. 

  • Tablet

    • 27 mg elemental iron (240 mg ferrous gluconate)

    • 28 mg elemental iron (248 mg ferrous gluconate)

    • 35 mg (300 mg ferrous gluconate)

    • 37.5 mg elemental iron (321 mg ferrous gluconate)

    • 38 mg elemental iron (324 mg ferrous gluconate)

  • Drops/oral solution

    • 10 mg elemental iron/5 mL

    • 10 mg elemental iron/10 mL

    • 18 mg elemental iron/2.5 mL

What are common Ferrous Gluconate doses?

  • Recommended daily intake (elemental iron):

    • For adults 19–50 years of age: 8 mg/day for men and 18 mg/day for women

    • For adults 51 years of age and older: 8 mg/day 

    • For pregnant women (adult and adolescent): 27 mg/day 

    • For lactating women 19 years of age and older: 9 mg/day 

    • For lactating girls 14–18 years: 10 mg/day 

    • For children 14–18 years: 11 mg/day for boys and 15 mg/day for girls

    • For children 9–13 years: 8 mg/day

    • For children 4–8 years: 10 mg/day

    • For children 1–3 years: 7 mg/day

    • For children 7–12 months: 11 mg/day

    • For newborns to infants up to the age of 6 months: 0.27 mg/day (adequate intake)

  • For iron deficiency anemia: 

    • In adults: 100–200 mg elemental iron daily taken in divided doses

    • In children: 60–120 mg elemental iron daily, depending on age

  • To prevent iron deficiency during pregnancy: 30 mg elemental iron per day 

  • For breastfed infants:

    • Preterm or low birth weight: 2–4 mg/kg elemental iron per day given as drops to a maximum of 15 mg elemental iron/day

    • Receiving insufficient iron from supplementary foods by age 6 months: 1 mg/kg elemental iron daily given as drops

Common Ferrous Gluconate prescriptions

  • Ferrous Gluconate
    100 tablets bottle

  • Ferrous Gluconate
    1000 tablets bottle

  • Ferrous Gluconate
    324 (37.5 fe)mg tablet

  • Ferrous Gluconate
    324 (38 fe)mg tablet

How to take Ferrous Gluconate

  • Follow the directions on the label. Do not take more than the recommended dose.

  • If taken under the supervision of a healthcare provider, do not take more than prescribed. Carefully follow the prescriber’s instructions about any special diet.

  • Take ferrous gluconate doses 30 minutes before or two hours after a meal. Take the medicine with a full glass of water or fruit juice. 

    • If the dose causes stomach problems, take it with food.

  • How to take ferrous gluconate tablets:

    • Swallow the tablet whole with a glass of water or other liquid. Do not crush, break, or chew it.

    • Store ferrous gluconate tablets in a closed container at room temperature in a cool, dry place.

  • How to administer ferrous gluconate drops or solution:

    • Shake the bottle well before administering a dose.

    • Use the calibrated oral syringe or dropper that comes with this medicine to measure doses. 

    • Use a calibrated teaspoon if indicated on the package directions

    • Take the dose in the mouth or mixed with water, juice, or other liquid.

    • Ask a healthcare provider if you need to give iron supplements to infants or children.

    • Store ferrous gluconate tablets at room temperature, out of the reach of children.

    • Follow the package instructions when storing ferrous gluconate liquid.

What to do if you miss a dose of Ferrous Gluconate

  • Take a missed dose when remembered. 

  • If you are taking one dose per day, take a missed dose on the day it was missed. Skip it if it’s the next day, and take that day’s dose.

  • If you’re taking more than one dose per day, take the missed dose when you remember it. If it’s almost time for the next dose, skip the missed dose and take the next dose at its regular time. 

  • Do not take a double dose to make up for a missed dose.

Ferrous Gluconate contraindications

  • You should not use this medicine if you have had an allergic reaction to iron supplements or if you have:

    • Hemochromatosis (a condition in which your digestive system absorbs too much iron)

    • Hemosiderosis (excessive iron deposits in the body’s tissues)

    • Hemolytic anemia

Ferrous Gluconate warnings

  • If you are pregnant, breastfeeding, or taking medications, don’t start ferrous gluconate supplements without talking to a healthcare provider.

  • Get medical advice before starting ferrous gluconate if you have:

    • Stomach or intestinal problems

    • Diabetes

    • An active infection

    • Porphyria

    • Other medical conditions

  • Make sure any doctor or healthcare provider who treats you knows that you are using this medicine. 

    • Iron supplements may affect certain medical tests.

  • Iron supplements can darken stools, even turning them black. This is normal (the iron is black), but can easily be confused with internal bleeding. If there are other symptoms, call a healthcare provider. 

  • Ferrous gluconate liquid may stain your teeth. 

    • Try diluting the medicine with water or other liquids (such as fruit juice or tomato juice) and using a straw to avoid getting the iron liquid on the teeth.

    • You can remove iron stains by brushing your teeth with baking soda or peroxide.

  • Accidental overdose of iron supplements is the leading cause of fatal poisoning in very young children. Store ferrous gluconate supplements in securely capped childproof containers out of the reach of children.

Ferrous Gluconate interactions

  • Iron supplements can block the body’s ability to absorb other drugs, particularly many types of antibiotics. If you are taking any prescription drugs, talk to a healthcare provider before taking ferrous gluconate or other iron supplements.

  • Tell any healthcare provider prescribing new medications that you are taking ferrous gluconate or other iron supplements.

  • Do not take oral iron supplements if you are also receiving iron injections.

  • Avoid taking ferrous gluconate with:

    • Antacids

    • Milk

    • Calcium-containing products

    • High-fiber foods

    • Caffeine

Ferrous Gluconate side effects

Serious side effects

Most serious side effects of iron supplements are due to chronic overuse or overdosing. Talk to a healthcare provider if you notice any signs or symptoms of iron poisoning or overdose, such as:

  • Black and tarry stools (with other symptoms), bloody stools, bloody vomit, blood clots in the vomit, persistent abdominal pain

  • Wheezing, shallow breathing, trouble breathing (especially when lying down)

  • Nausea, vomiting, pallor, blue skin

  • Drowsiness, dizziness, confusion, lethargy, seizures, coma

  • Rapid breathing, rapid heart rate

  • Weakness, yellowing of the skin or eyes

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

Less serious side effects

  • Nausea

  • Vomiting

  • Constipation

  • Diarrhea

  • Gas

  • Stomach discomfort

  • Metallic taste in the mouth

  • Change in stool color

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