What is Fiorinal: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Fiorinal overview

BRAND NAMES:

  • Fiorinal, Fiorinal

Generic Names:

  • Butalbital-Aspirin-Caffeine

Uses:

  • Treats tension headaches and mild to moderate pain. This medicine contains a barbiturate.

Therapeutic Classes:

  • Butalbital/Salicylate, Aspirin Combination

Forms:

  • Capsule, Tablet

How it’s taken:

  • By mouth

What is Fiorinal used for?

What form(s) does Fiorinal come in

  • Capsule

  • Tablet

What are common Fiorinal doses?

  • Capsule 50-325-40MG

Common Fiorinal prescriptions

  • Fiorinal
    50-325-40mg capsule

How to take Fiorinal

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • This medicine may be taken with food or milk if it upsets your stomach.

  • This medicine works best if you take it at the first sign of pain. Do not wait until the pain is severe.

  • Your doctor will tell you how much medicine to use. Do not use more than directed. Do not increase your dose without your doctor's approval.

  • This medicine works best if you take it at the first sign of pain. Do not wait until the pain is severe.

  • Your doctor will tell you how much medicine to use. Do not use more than directed. Do not increase your dose without your doctor's approval.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • This medicine may be taken with food or milk if it upsets your stomach.

What to do if you miss a dose of Fiorinal

Fiorinal contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to butalbital, aspirin or other salicylates, arthritis medicine, or caffeine. Do not use this medicine if you have porphyria, stomach ulcers, or a bleeding disorder.

Fiorinal warnings

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.

  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • This medicine may make you dizzy or drowsy. Do not drive or do anything that could be dangerous until you know how this medicine affects you.

  • Do not drink alcohol while you are using this medicine. Alcohol combined with this medicine may cause life-threatening problems.

  • Do not give this medicine to a child who has a fever or symptoms of an infection. This medicine contains aspirin. Aspirin can cause a life-threatening reaction called Reye syndrome in children.

  • Tell your doctor if you are pregnant or breastfeeding, or you have asthma, other lung disease, or liver or kidney problems.

Fiorinal interactions

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.

  • This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • This medicine may make you dizzy or drowsy. Do not drive or do anything that could be dangerous until you know how this medicine affects you.

  • Do not drink alcohol while you are using this medicine. Alcohol combined with this medicine may cause life-threatening problems.

  • Do not give this medicine to a child who has a fever or symptoms of an infection. This medicine contains aspirin. Aspirin can cause a life-threatening reaction called Reye syndrome in children.

  • Some medicines can affect how this medicine works. Tell your doctor if you are taking any of the following: Blood thinner, such as warfarinInsulin or oral diabetes medicineMedicine that makes you sleepy, such as allergy medicine or narcotic pain medicineMethotrexate or 6-mercaptopurineNSAID pain or arthritis medicine, such as aspirin, diclofenac, ibuprofen, naproxen, celecoxibProbenecid or sulfinpyrazoneSteroid medicine, such as dexamethasone, hydrocortisone, methylprednisolone, prednisone

Fiorinal side effects

Serious Side Effects

  • Chest tightness, shortness of breath, or trouble breathing

  • Fast, slow, or pounding heartbeat

  • Fever, tiredness, itching, and red spots or bumps on your skin

  • Blistering, peeling, red skin rash

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

Less Serious Side Effects

  • Lightheadedness, dizziness, drowsiness

  • Nausea, vomiting, constipation, gas

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