Hydroxyprogesterone Caproate is a generic prescription injection that is used to prevent premature birth in women with a history of preterm, single-child births. The active ingredient in Hydroxyprogesterone Caproate, oxytocin, provokes muscles in the uterus to contract. Generic Hydroxyprogesterone Caproate is administered by a healthcare professional and is not available for purchase at consumer pharmacies. Only brand-name Makena is sold at consumer pharmacies as a subcutaneous autoinjector. The price of Hydroxyprogesterone Caproate is $51.09 at full price. Ask the case manager at the clinic or doctor's office where you receive your Hydroxyprogesterone Caproate injection if they will accept a SingleCare Hydroxyprogesterone Caproate coupon; you could pay only $347.39.
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Prices updated: 05/06/2026
Hydroxyprogesterone Caproate is a generic prescription injection that is used to prevent premature birth in women with a history of preterm, single-child births. The active ingredient in Hydroxyprogesterone Caproate, oxytocin, provokes muscles in the uterus to contract. Generic Hydroxyprogesterone Caproate is administered by a healthcare professional and is not available for purchase at consumer pharmacies. Only brand-name Makena is sold at consumer pharmacies as a subcutaneous autoinjector. The price of Hydroxyprogesterone Caproate is $51.09 at full price. Ask the case manager at the clinic or doctor's office where you receive your Hydroxyprogesterone Caproate injection if they will accept a SingleCare Hydroxyprogesterone Caproate coupon; you could pay only $347.39.
Hydroxyprogesterone Caproate is a generic prescription injection that is used to prevent premature birth in women with a history of preterm, single-child births. The active ingredient in Hydroxyprogesterone Caproate, oxytocin, provokes muscles in the uterus to contract. Generic Hydroxyprogesterone Caproate is administered by a healthcare professional and is not available for purchase at consumer pharmacies. Only brand-name Makena is sold at consumer pharmacies as a subcutaneous autoinjector. The price of Hydroxyprogesterone Caproate is $51.09 at full price. Ask the case manager at the clinic or doctor's office where you receive your Hydroxyprogesterone Caproate injection if they will accept a SingleCare Hydroxyprogesterone Caproate coupon; you could pay only $347.39.
The price of Hydroxyprogesterone Caproate is $51.09 at full retail price. A SingleCare Hydroxyprogesterone Caproate coupon reduces that cost to $347.39 if the clinic where you receive Hydroxyprogesterone Caproate injections will accept SingleCare.
Your copay for Hydroxyprogesterone Caproate with insurance will vary depending on your plan and the price charged for Hydroxyprogesterone Caproate by the clinic or doctor's office where you get your injection. However, Hydroxyprogesterone Caproate may be covered by your health insurance as a medical benefit rather than a prescription drug benefit. Ask the clinic where you receive Hydroxyprogesterone Caproate injections if they will accept a SingleCare Hydroxyprogesterone Caproate coupon. If they do, you could pay only $347.39 for your injection.
Hydroxyprogesterone Caproate is not included in Medicare prescription drug plans, but is usually covered under Medicare Part B as a medical benefit. Patients without Medicare should consider asking the clinic or medical practice that administers Hydroxyprogesterone Caproate injections if they will accept a SingleCare Hydroxyprogesterone Caproate coupon. This could cut the price down to $347.39.
Hydroxyprogesterone Caproate is a generic prescription drug manufactured by Prasco, Aurobindo, Mylan, and other generic manufacturers. Generic Hydroxyprogesterone Caproate is administered only by healthcare professionals and not sold at commercial pharmacies. The brand-name version, Makena, is available at commercial pharmacies as an autoinjector.
Hydroxyprogesterone Caproate is a generic prescription drug that helps prevent preterm delivery in women who have a history of premature birth of a single child. Hydroxyprogesterone Caproate is effective at statistically improving the incidence of premature birth, but it has not been studied in terms of improving the health or survival rates of the baby.
Hydroxyprogesterone Caproate injections are started at 16 to 20 weeks into the pregnancy. Injections are given once weekly in the gluteus maximums until week 37.
While generic Hydroxyprogesterone Caproate is administered only as a deep intramuscular injection by a healthcare professional, the brand-name version of Hydroxyprogesterone Caproate is sold at commercial pharmacies as a subcutaneous auto-injector.
Hydroxyprogesterone Caproate is also used off-label as menopausal hormone replacement therapy, as feminizing hormone therapy for transgender patients, and to treat prostate cancer or enlarged prostate in men.
The most common side effects of Hydroxyprogesterone Caproate are site reactions to the injection, such as pain, itching, bruising, or a hard lump. These reactions should are temporary and only last one or two days.
Common side effects of Hydroxyprogesterone Caproate include but are not limited to hives, itching, nausea, migraine, and diarrhea. The most serious side effects of Hydroxyprogesterone Caproate are the possibility of high blood pressure or blood clots.
Although not common, in clinical trials, Hydroxyprogesterone Caproate increased pregnancy complications including the risk of miscarriage, stillbirth, preterm labor, preeclampsia (gestational high blood pressure), gestational diabetes, and low amniotic fluid.
Mental and mood changes have not been reported. Allergic reactions are rare.
This is not a complete list of side effects. Consult with your doctor if you have concerns or questions about the possible side effects of Hydroxyprogesterone Caproate.
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SingleCare is a prescription discount service that offers free coupons on thousands of prescription drugs. It can be used whether you have insurance, Medicare, Medicaid, or none of the above, but it cannot be combined with insurance.
SingleCare provides transparent drug pricing, so you can compare discounts at pharmacies near you. Browse singlecare.com to find drug discounts, helpful information about your prescription, and resources to help you make informed health decisions.
Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2026 SingleCare Administrators. All rights reserved