Diphenoxylate-Atropine is a generic prescription drug that treats severe diarrhea by relaxing the intestines. Diphenoxylate-Atropine is prescribed along with fluid and electrolyte treatment. Diphenoxylate is an opioid that slows the contractions of muscles in the intestines by binding to receptors on the nerves. Atropine is intended to prevent people from abusing diphenoxylate by overdosing in order to get high. Taken at prescribed doses, atropine has no effect. Taken in high doses, atropine results in harsh, unpleasant side effects. On average, the retail price of Diphenoxylate-Atropine is $39.80 for 30, 2.5-0.025mg tablets, but only costs $14.11 for 30, 2.5-0.025mg tablets with a SingleCare Diphenoxylate-Atropine coupon. Many local pharmacies accept SingleCare.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
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Prices updated: 12/05/2025
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Diphenoxylate-Atropine is a generic prescription drug that treats severe diarrhea by relaxing the intestines. Diphenoxylate-Atropine is prescribed along with fluid and electrolyte treatment. Diphenoxylate is an opioid that slows the contractions of muscles in the intestines by binding to receptors on the nerves. Atropine is intended to prevent people from abusing diphenoxylate by overdosing in order to get high. Taken at prescribed doses, atropine has no effect. Taken in high doses, atropine results in harsh, unpleasant side effects. On average, the retail price of Diphenoxylate-Atropine is $39.80 for 30, 2.5-0.025mg tablets, but only costs $14.11 for 30, 2.5-0.025mg tablets with a SingleCare Diphenoxylate-Atropine coupon. Many local pharmacies accept SingleCare.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Diphenoxylate-Atropine Retail Price | Diphenoxylate-Atropine SingleCare Price |
|---|---|---|
| CVS Pharmacy | $43.28 | $30.00 |
| Walmart | $30.00 | $13.50 |
| Walgreens | $12.00 | $12.00 |
| Kroger Pharmacy | $31.50 | $10.31 |
| Albertsons Pharmacy | $22.80 | $10.20 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Diphenoxylate-Atropine is a generic prescription drug that treats severe diarrhea by relaxing the intestines. Diphenoxylate-Atropine is prescribed along with fluid and electrolyte treatment. Diphenoxylate is an opioid that slows the contractions of muscles in the intestines by binding to receptors on the nerves. Atropine is intended to prevent people from abusing diphenoxylate by overdosing in order to get high. Taken at prescribed doses, atropine has no effect. Taken in high doses, atropine results in harsh, unpleasant side effects. On average, the retail price of Diphenoxylate-Atropine is $39.80 for 30, 2.5-0.025mg tablets, but only costs $14.11 for 30, 2.5-0.025mg tablets with a SingleCare Diphenoxylate-Atropine coupon. Many local pharmacies accept SingleCare.
Cash-paying customers can expect to pay $39.80 for 30, 2.5-0.025mg tablets with a SingleCare Diphenoxylate-Atropine coupon. For all your other prescription drug needs, you can save as much as an 80% discount with SingleCare savings cards.
Diphenoxylate-Atropine copays vary by insurance plan. With SingleCare, Diphenoxylate-Atropine costs as little as $14.11 for 30, 2.5-0.025mg tablets which may be lower than your insurance copay. Before you overpay for Diphenoxylate-Atropine, ask your local pharmacist to compare your insurance copay to the SingleCare discount card.
Diphenoxylate-Atropine is usually covered by Medicare Advantage and Medicare Part D prescription drug plans. For those who are not Medicare-eligible, a SingleCare Diphenoxylate-Atropine coupon offers significant savings at major pharmacies: CVS, Walmart, Walgreens, Duane Reade, and many others.
Diphenoxylate-Atropine is a generic prescription drug with diphenoxylate as the active ingredient and atropine to prevent abuse. It is supplied by Mylan, Upsher-Smith, and other generic manufacturers. The brand-name version of Diphenoxylate-Atropine is Pfizer's Lomotil. If you have a prescription for Lomotil and are looking for more information or valuable savings coupons, search the SingleCare website or app.
Diphenoxylate-Atropine is a combination prescription drug used along with appropriate fluid and electrolyte therapy to treat diarrhea, a condition in which the intestines pass waste too quickly. Severe diarrhea can cause life-threatening dehydration.
While Diphenoxylate-Atropine has two active ingredients, only diphenoxylate treats diarrhea. Diphenoxylate is an opioid. It binds to receptors on nerves in the intestines and slows them down. As a result, diphenoxylate reduces the frequency and intensity of intestinal muscle contractions, which means that material moves through the intestines more slowly.
Diphenoxylate is an opioid that, like all opioids, can cause a “high” when taken in large enough quantities. Atropine helps prevent abuse of the diphenoxylate. It is present in Diphenoxylate-Atropine in subclinical doses that will have no effect. In larger doses, atropine produces unpleasant and even harsh side effects.
Diphenoxylate-Atropine tablets contain 2.5 mg of diphenoxylate and 0.025 mg of atropine. Two tablets are taken four times per day. Improvement in diarrhea symptoms should occur in 48 hours. Diphenoxylate-Atropine is discontinued if no improvement is made in 10 days.
Diphenoxylate is a narcotic, so most people taking Diphenoxylate-Atropine will experience drowsiness, dizziness, lightheadedness, sleepiness, and feeling tired. Other mental and mood changes commonly experienced include euphoria, depression, nervousness, confusion, or depression.
Common physical side effects include but are not limited to, nausea, vomiting, upset stomach, loss of appetite, headache, blurred vision, skin rash, and itching.
An diphenoxylate overdose is the same as any other opioid overdose. Overdose can result in slowed reflexes, slowed breathing, slowed heart rate, coma, and even death.
The atropine in Diphenoxylate-Atropine is intended to produce unpleasant but harmless side effects, but in the dose prescribed, the effects from the atropine will be minimal. If more than the prescribed dose prescribed is taken, the side effects of the atropine will include dry skin, dry mouth, lack of sweating, headache, rapid heartbeat, loss of balance, and blurred vision.
Some patients will show allergic reactions, typically rash, hives, swelling, or trouble breathing. Allergic reactions could be severe, including anaphylaxis, a dangerous drop in blood pressure. Get emergency medical help if you suspect you are having an allergic reaction to Diphenoxylate-Atropine.
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Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved