What is Integra Plus: Uses, Warnings & Interactions

Updated Jul 21, 2025  •  Published Dec 30, 2020

Integra Plus is a prescription iron and folate supplement that treats people with both iron deficiency anemia and folate deficiency. Each capsule provides 125 mg of elemental iron in the form of ferrous fumarate and polysaccharide iron complex, a form of iron that causes fewer side effects than other forms of iron. Integra Plus is a specialty product, so it may take a pharmacy one or two days to fill a prescription.

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Integra Plus overview

BRAND NAMES:

  • Integra, Integra Plus

Generic Names:

  • Ferrous fumarate, polysaccharide iron complex

Uses:

  • Treats iron deficiency anemia and folate deficiency or iron deficiency anemia and vitamin C deficiency.

Therapeutic Classes:

  • Iron supplement, folate supplement, B-complex multivitamin, nutritive agent

Forms:

  • Capsule

How it’s taken:

  • By mouth

What is Integra Plus used for?

Integra Plus is a prescription iron supplement that treats iron deficiency anemia and folate deficiency or iron deficiency and vitamin C deficiency due to excessive blood loss, prolonged menstrual bleeding, extended convalescence, metabolic stress, chronic illness, pregnancy, advanced age, or puberty.

What form(s) does Integra Plus come in

  • Capsule

    • 125 mg elemental iron/1,000 mcg folic acid/210 mg vitamin C/B-complex vitamins

What are common Integra Plus doses?

  • For iron deficiency anemia: One capsule/day taken between meals

Common Integra Plus prescriptions

  • Integra Plus
    1 bottle capsule

How to take Integra Plus

  • Follow the prescriber’s instructions or the package instructions.

  • Take only one capsule daily except under a doctor’s instructions.

  • Take the capsule between meals.

  • Swallow the capsule whole with a drink of water. Do not open, crush, or chew it.

  • Store Integra Plus capsules at room temperature in a cool, dry place out of the reach of children.

What to do if you miss a dose of Integra Plus

  • Ask the prescriber how to handle a missed dose.

  • Missed doses can usually be taken on the day they’re missed.

  • The prescriber may advise that missed doses be skipped if it’s the next day.

  • Do not take two doses to make up for a missed dose.

Integra Plus contraindications

  • This medicine is not right for everyone.

  • Do not use Integra Plus if you have:

    • Known allergies to iron supplements

    • Hemochromatosis (excessive iron absorption in the intestines)

    • Hemosiderosis (excessive iron deposits in the body’s tissues)

    • Hemolytic anemia

    • Pernicious anemia

Integra Plus warnings

  • Tell other healthcare providers treating you that you are taking Integra.

    • Iron supplements may affect some important medical tests

  • Keep all appointments with the prescriber.

  • Before taking Integra Plus, tell the prescribing healthcare professional if you have:

    • Stomach or intestinal problems

    • Diabetes

    • An active infection

    • Porphyria

    • Any other medical condition

  • Iron typically turns stools dark or coal-black. This is normal and nothing to worry about unless there are other symptoms of gastrointestinal bleeding.

  • Accidental overdose of iron supplements is one of the leading causes of fatal poisoning in very young children. Keep Integra Plus securely sealed and out of the reach of children.

Integra Plus interactions

  • Before taking Integra Plus, tell the prescriber about all the drugs and supplements regularly taken, particularly:

    • Fluoxetine

    • Phenytoin

    • Capecitabine

  • Tell doctors treating you about Integra Plus before they prescribe new medications. Iron supplements can block the body’s absorption of other drugs like antibiotics. 

  • People receiving iron injections should avoid taking oral iron supplements.

  • Avoid taking Integra Plus with:

    • Antacids

    • Milk

    • Calcium-containing products

    • High-fiber foods

    • Caffeine

Integra Plus side effects

Serious side effects

Talk to a healthcare provider if you notice any signs or symptoms of iron poisoning or overdose, including:

  • Nausea, vomiting, pale skin, blue skin, drowsiness

  • Sleepiness, dizziness, confusion, lethargy, seizures, coma

  • Blood in the stools, vomiting blood, persistent abdominal pain, black and tarry stools (along with other symptoms)

  • Trouble breathing, shallow breathing, wheezing, breathing problems when lying down 

  • Rapid breathing, rapid heart rate

  • Weakness, yellowing of the skin or eyes

  • Allergic reaction: Itching, skin rash, hives, swelling of the face, lips, mouth, or throat, trouble breathing

Less serious side effects

  • Nausea

  • Vomiting

  • Constipation

  • Diarrhea

  • Flatulence

  • Metallic taste in the mouth

  • Dark or tar-black stools

  • Sleep problems

  • Increased anxiety

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