What is Fusion Plus? Uses, warnings & side effects

Updated Jul 28, 2025  •  Published Dec 30, 2020

Fusion Plus is a prescription iron and folate supplement for people with both iron deficiency anemia and folate deficiency. The active ingredients in Fusion Plus are ferrous fumarate, polysaccharide iron complex, folic acid, vitamin C, and B-complex vitamins. Fusion Plus is a specialty product that pharmacies will need to custom order, so it may take 24 or 48 hours to fill a prescription.

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Fusion Plus overview

BRAND NAMES:

  • Fusion, Fusion Plus

Generic Names:

  • Ferrous fumarate, polysaccharide iron complex

Uses:

  • Treats iron deficiency anemia and folate deficiency. Can also treat iron deficiency anemia and vitamin C deficiency in situations requiring vitamin B supplementation

Therapeutic Classes:

  • Iron supplement, folate supplement, B-complex multivitamin, nutritive agent

Forms:

  • Capsule

How it’s taken:

  • By mouth

What is Fusion Plus used for?

Fusion Plus is a prescription iron supplement that treats iron deficiency anemia and folate deficiency due to extended convalescence, prolonged menstrual bleeding, excessive blood loss, pregnancy, puberty, or advanced age. It also treats iron deficiency anemia and vitamin C deficiency when these problems are also associated with chronic illness or metabolic stress that also requires vitamin B supplementation. 

What form(s) does Fusion Plus come in?

  • Capsule

    • 130 mg elemental iron/1,250 mcg folic acid/75 mg vitamin C/B-complex vitamins/probiotics

What are common Fusion Plus dosages?

  • For iron deficiency anemia: One capsule daily taken between meals

Fusion Plus images - What does Fusion Plus look like?

  • Fusion Plus
    1 bottle capsule

How to take Fusion Plus

  • Follow all the doctor’s or package’s instructions.

  • Take only one capsule daily unless prescribed more.

  • Capsules are taken between meals on an empty stomach.

  • Swallow the capsule whole with a drink of water. Do not open, crush, break, or chew it.

  • Store Fusion P

What to do if you miss a dose of Fusion Plus

  • Ask the prescriber how to handle a missed dose.

  • A missed dose can probably be taken on the day it’s missed but not the next day.

  • Do not take two doses to make up for a missed dose.

Fusion Plus contraindications - Who shouldn't take Fusion Plus?

  • High-dose iron supplements are not safe for everyone.

  • Do not use Fusion Plus if you have:

    • Known allergies to iron supplements

    • Hemochromatosis (excessive iron absorption in the gut)

    • Hemosiderosis (excessive iron deposits in the body’s tissues)

    • Hemolytic anemia

    • Pernicious anemia

Fusion Plus warnings

  • Tell other healthcare providers treating you that you are taking Fusion.

    • Iron supplements can distort the results of certain medical tests

  • Don’t miss appointments with the prescriber. Regular visits are required to monitor therapy and spot possible side effects.

  • Before taking Fusion Plus, tell the prescriber if you have:

    • Stomach or intestinal problems

    • Diabetes

    • An active infection

    • Porphyria

    • Any other medical condition

  • Iron typically turns stools dark or tar-black. This is normal but easily confused with internal bleeding. If there are other symptoms, contact a healthcare professional.

  • Very young children can get seriously ill from iron supplements. Iron overdoses are the leading cause of poisoning fatalities in children. Keep Fusion Plus securely sealed and out of the reach of children.

Fusion Plus interactions & what to avoid when taking Fusion Plus

  • Before taking Fusion Plus, tell the prescriber about all the drugs and supplements you take on a regular basis, particularly:

    • Antibiotics

    • Fluoxetine

    • Phenytoin

    • Capecitabine

  • Tell doctors treating you about Fusion Plus before they prescribe new medications. Iron supplements can block the body’s absorption of other drugs, reducing their effectiveness. 

  • Avoid taking Fusion Plus with:

    • Iron injections

    • Antacids

    • Milk

    • Calcium-containing products

    • High-fiber foods

    • Caffeine

Fusion Plus side effects - How does Fusion Plus make you feel?

Serious side effects

Talk to a healthcare provider if you notice any signs or symptoms of iron poisoning or overdose, including:

  • Nausea, vomiting, pale skin, blue skin

  • Drowsiness, dizziness, confusion, lethargy, seizures, coma

  • Blood in the stools, abdominal pain that won’t stop, vomiting blood, black and tarry stools (along with other symptoms)

  • Nausea, vomiting, pale skin, blue skin

  • Trouble breathing, shallow breathing, wheezing, breathing problems when lying down 

  • Rapid breathing, rapid heart rate

  • Weakness, yellowing of the skin or eyes

  • Allergic reaction: Skin rash, hives, itchy skin, swelling of the face, lips, mouth, or throat, trouble breathing

Less serious side effects

  • Diarrhea

  • Constipation

  • Dark or black stools

  • Nausea

  • Vomiting

  • Gas

  • Metallic taste in the mouth

  • Trouble sleeping

  • Increased anxiety

Sources:

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