What is Fusion Plus: Uses, Warnings & Interactions
Updated Jul 28,
2025 • Published Dec 30,
2020
Fusion Plus is a prescription iron and folate supplement for people with both iron deficiency anemia and folate deficiency. The active ingredients in Fusion Plus are ferrous fumarate, polysaccharide iron complex, folic acid, vitamin C, and B-complex vitamins. Fusion Plus is a specialty product that pharmacies will need to custom order, so it may take 24 or 48 hours to fill a prescription.
Treats iron deficiency anemia and folate deficiency. Can also treat iron deficiency anemia and vitamin C deficiency in situations requiring vitamin B supplementation
Therapeutic Classes:
Iron supplement, folate supplement, B-complex multivitamin, nutritive agent
Forms:
Capsule
How it’s taken:
By mouth
What is Fusion Plus used for?
Fusion Plus is a prescription iron supplement that treats iron deficiency anemia and folate deficiency due to extended convalescence, prolonged menstrual bleeding, excessive blood loss, pregnancy, puberty, or advanced age. It also treats iron deficiency anemia and vitamin C deficiency when these problems are also associated with chronic illness or metabolic stress that also requires vitamin B supplementation.
For iron deficiency anemia: One capsule daily taken between meals
Common Fusion Plus prescriptions
Fusion Plus 1 bottle capsule
How to take Fusion Plus
Follow all the doctor’s or package’s instructions.
Take only one capsule daily unless prescribed more.
Capsules are taken between meals on an empty stomach.
Swallow the capsule whole with a drink of water. Do not open, crush, break, or chew it.
Store Fusion P
What to do if you miss a dose of Fusion Plus
Ask the prescriber how to handle a missed dose.
A missed dose can probably be taken on the day it’s missed but not the next day.
Do not take two doses to make up for a missed dose.
Fusion Plus contraindications
High-dose iron supplements are not safe for everyone.
Do not use Fusion Plus if you have:
Known allergies to iron supplements
Hemochromatosis (excessive iron absorption in the gut)
Hemosiderosis (excessive iron deposits in the body’s tissues)
Hemolytic anemia
Pernicious anemia
Fusion Plus warnings
Tell other healthcare providers treating you that you are taking Fusion.
Iron supplements can distort the results of certain medical tests
Don’t miss appointments with the prescriber. Regular visits are required to monitor therapy and spot possible side effects.
Before taking Fusion Plus, tell the prescriber if you have:
Stomach or intestinal problems
Diabetes
An active infection
Porphyria
Any other medical condition
Iron typically turns stools dark or tar-black. This is normal but easily confused with internal bleeding. If there are other symptoms, contact a healthcare professional.
Very young children can get seriously ill from iron supplements. Iron overdoses are the leading cause of poisoning fatalities in children. Keep Fusion Plus securely sealed and out of the reach of children.
Fusion Plus interactions
Before taking Fusion Plus, tell the prescriber about all the drugs and supplements you take on a regular basis, particularly:
Antibiotics
Fluoxetine
Phenytoin
Capecitabine
Tell doctors treating you about Fusion Plus before they prescribe new medications. Iron supplements can block the body’s absorption of other drugs, reducing their effectiveness.
