Klayesta topical powder is a prescription antifungal medication used to treat yeast infections (Candida) of the skin. The cash price of Klayesta is about $107.64 per 1, 60gm of 100000unit/gm bottle. However, the Klayesta price could be reduced to $21.16 for 1, 60gm of 100000unit/gm bottle by using a SingleCare coupon.
Edit your dosage
1 bottle, 15gm of 100000unit/gmEdit
You have 0.00 in available bonus savings. Bonus savings will be automatically applied to your next eligible prescription fill.
Show this free card to your pharmacist.
SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.
Prices updated: 05/08/2026
Klayesta topical powder is a prescription antifungal medication used to treat yeast infections (Candida) of the skin. The cash price of Klayesta is about $107.64 per 1, 60gm of 100000unit/gm bottle. However, the Klayesta price could be reduced to $21.16 for 1, 60gm of 100000unit/gm bottle by using a SingleCare coupon.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Klayesta Retail Price | Nystatin Retail Price | Nystatin SingleCare Price |
|---|---|---|---|
| CVS Pharmacy | $110.13 | $105.73 | $65.85 |
| Walmart | - | $39.97 | $27.52 |
| Walgreens | $99.56 | $94.67 | $43.27 |
| Kroger Pharmacy | - | $90.19 | $34.74 |
| Albertsons Pharmacy | - | $100.65 | $38.40 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Klayesta topical powder is a prescription antifungal medication used to treat yeast infections (Candida) of the skin. The cash price of Klayesta is about $107.64 per 1, 60gm of 100000unit/gm bottle. However, the Klayesta price could be reduced to $21.16 for 1, 60gm of 100000unit/gm bottle by using a SingleCare coupon.
The generic form of Klayesta costs $21.16 for 1, 60gm of 100000unit/gm bottle with a free Klayesta coupon from SingleCare. But, you could pay even less depending on your prescription details. Use the dropdown menu above to update your Rx info (i.e., generic/brand, quantity, dosage, form) to see the most accurate prices of Klayesta with SingleCare at your local pharmacies.
Without insurance coverage, Klayesta costs around $107.64 for 1, 60gm of 100000unit/gm bottle. Using a Klayesta coupon without insurance can decrease that cost to $21.16 for 1, 60gm of 100000unit/gm bottle.
Klayesta coverage varies by plan. Brand-name Klayesta is not preferred by many insurance plans, but generic Klayesta, nystatin, is. If covered, copays for Klayesta with insurance vary by plan.
Some Medicare plans cover Klayesta. Those that don’t usually cover generic Klayesta. The copay and other out-of-pocket costs vary by plan, deductible, and coverage phase. If Medicare doesn’t cover Klayesta, you can use a SingleCare coupon for Klayesta instead to save.
Some Medicaid programs cover Klayesta, but many don’t list it as a preferred drug. Medicaid plans usually cover generic nystatin topical medications instead.. If Medicaid doesn’t cover Klayesta, you can use a SingleCare Klayesta coupon instead to save.
Nystatin topical powder is the generic version of Klayesta.
When looking for ways to save on Klayesta, the first place to start is by using a SingleCare prescription discount card. Sign up for SingleCare’s free loyalty program to earn extra savings on every refill. Registration is optional, but you’ll unlock lower prices on Klayesta and thousands of other medications.
You can also use SingleCare to compare Klayesta prices at pharmacies near you before each refill. You could save hundreds of dollars on certain medications simply by choosing the pharmacy with the best price.
Unfortunately, Klayesta does not have any manufacturer discounts at this time. However, you can ask your healthcare provider for free Klayesta samples (although this is not a long-term solution), apply for Medicare Extra Help if eligible, or use a flexible spending account (FSA) or health savings account (HSA) if available.
Yes. Over-the-counter (OTC) topical antifungals like clotrimazole, miconazole, and terbinafine are available as powders and treat the same Candida infections as Klayesta, but they are not as strong. Additionally, switching to generic nystatin topical powder can be a cheaper alternative. Another topical prescription antifungal is itraconazole. Alternatively, oral fluconazole may be prescribed to treat a fungal infection. Talk to your healthcare provider about the best treatment option for you.
SingleCare is accepted at most major pharmacies and grocery stores, i.e., Walgreens, Kroger, Walmart, CVS, Safeway, and more. You can text, email, print, or save your free Klayesta coupon to your mobile wallet and show your pharmacist at the counter.
Josephine Bawab, Pharm.D., graduated from Virginia Commonwealth University School of Pharmacy. She began working in community pharmacy in 2012 and has worked for multiple chain pharmacies since then. She is passionate about helping patients and precepting students. She currently works and resides in Virginia, where she is just a few minutes away from the beach.
...SingleCare is accepted at most national pharmacies and grocers, including the following:
Health education, drug info, wellness & more
SingleCare is a prescription discount service that offers free coupons on thousands of prescription drugs. It can be used whether you have insurance, Medicare, Medicaid, or none of the above, but it cannot be combined with insurance.
SingleCare provides transparent drug pricing, so you can compare discounts at pharmacies near you. Browse singlecare.com to find drug discounts, helpful information about your prescription, and resources to help you make informed health decisions.
Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
© 2026 SingleCare Administrators. All rights reserved
© 2026 SingleCare Administrators. All rights reserved