Lonsurf is a brand-name combination prescription drug used to treat colon, rectal, or stomach cancers that have spread to other parts of the body and not responded adequately to other drugs. One of the active ingredients in Lonsurf, trifluridine, works by blocking the cancer cell's ability to grow by corrupting its genetic information. The other active ingredient, tipiracil, slows down the body's breakdown of trifluridine so it has a better chance of working against the cancer cells. The cost of Lonsurf is normally $27,787.56 at full price. A SingleCare Lonsurf coupon reduces that price to $23,543.96 for every 80, 20-8.19mg tablets. You can find more information in our FAQs below.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.
Prices updated: 04/19/2026
Lonsurf is a brand-name combination prescription drug used to treat colon, rectal, or stomach cancers that have spread to other parts of the body and not responded adequately to other drugs. One of the active ingredients in Lonsurf, trifluridine, works by blocking the cancer cell's ability to grow by corrupting its genetic information. The other active ingredient, tipiracil, slows down the body's breakdown of trifluridine so it has a better chance of working against the cancer cells. The cost of Lonsurf is normally $27,787.56 at full price. A SingleCare Lonsurf coupon reduces that price to $23,543.96 for every 80, 20-8.19mg tablets. You can find more information in our FAQs below.
Lonsurf is a brand-name combination prescription drug used to treat colon, rectal, or stomach cancers that have spread to other parts of the body and not responded adequately to other drugs. One of the active ingredients in Lonsurf, trifluridine, works by blocking the cancer cell's ability to grow by corrupting its genetic information. The other active ingredient, tipiracil, slows down the body's breakdown of trifluridine so it has a better chance of working against the cancer cells. The cost of Lonsurf is normally $27,787.56 at full price. A SingleCare Lonsurf coupon reduces that price to $23,543.96 for every 80, 20-8.19mg tablets. You can find more information in our FAQs below.
Lonsurf costs $27,787.56, but only $23,543.96 using a SingleCare savings card. SingleCare is welcomed nationwide at major pharmacies, such as Kroger, Fry's, Harris Teeter, Walgreens, and many others.
Depending on your insurance plan, copay costs for Lonsurf can vary dramatically and could be high. Ask your pharmacist to compare your Lonsurf insurance copay to your price using a SingleCare Lonsurf coupon, which you can get for free right here. With SingleCare, Lonsurf costs only $23,543.96, which may be less than what you pay with insurance.
Medicare prescription drug plans usually provide coverage for Lonsurf, but the copay could be high. If you don't have coverage for Lonsurf or if your copay is very high, a SingleCare Lonsurf coupon is a reliable way to save money. With SingleCare, the price of Lonsurf is $23,543.96 for 80, 20-8.19mg tablets.
Lonsurf is a brand-name prescription drug with the active ingredients, trifluridine, and tipiracil. Generic Lonsurf is not available at this time.
Lonsurf is a brand-name combination prescription drug used to treat colon, rectal, or stomach cancer that has spread to other parts of the body and has not responded adequately to other drugs.
One of the active ingredients in Lonsurf, trifluridine, corrupts the genetic information in cancer cells, blocking their ability to produce new cancer cells. The other active ingredient, tipiracil, slows down the body's breakdown of trifluridine and so allows it more time to work against cancer cells.
Lonsurf is taken as a tablet twice a day with food on a 28-day cycle. Lonsurf is initially taken for five days followed by two days not taking the medication. The cycle is repeated once, followed by a two-week break.
Common side effects of Lonsurf include, but are not limited to, nausea, vomiting, diarrhea, abdominal pain, decreased appetite, weakness, fever, hair loss, runny nose, and changes in taste.
Serious side effects include anemia and low to severely low white blood cell counts, which could put the patient at risk for potentially serious infections.
Allergic reactions are rare. Watch for important signs of an allergic reaction, such as fever, sore throat, swelling, itching, or rash, and talk to your doctor if you suspect an allergic reaction.
SingleCare is accepted at most national pharmacies and grocers, including the following:
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SingleCare is a prescription discount service that offers free coupons on thousands of prescription drugs. It can be used whether you have insurance, Medicare, Medicaid, or none of the above, but it cannot be combined with insurance.
SingleCare provides transparent drug pricing, so you can compare discounts at pharmacies near you. Browse singlecare.com to find drug discounts, helpful information about your prescription, and resources to help you make informed health decisions.
Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2026 SingleCare Administrators. All rights reserved