Lonsurf Coupons & Prices

Lonsurf is a brand-name combination prescription drug used to treat colon, rectal, or stomach cancers that have spread to other parts of the body and not responded adequately to other drugs. One of the active ingredients in Lonsurf, trifluridine, works by blocking the cancer cell's ability to grow by corrupting its genetic information. The other active ingredient, tipiracil, slows down the body's breakdown of trifluridine so it has a better chance of working against the cancer cells. The cost of Lonsurf is normally $27,787.56 at full price. A SingleCare Lonsurf coupon reduces that price to $23,543.96 for every 80, 20-8.19mg tablets. You can find more information in our FAQs below.

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Lonsurf coupon at Kroger Pharmacy
$23546.96
$ 23,544
$3 off with signupwith signup

Show this free card to your pharmacist.

This coupon is not insurance.
Lonsurf coupon at Harris Teeter Pharmacy
$23546.96
$ 23,544
$3 off with signupwith signup
Lonsurf coupon at Food Lion Pharmacy
$ 24,561
Lonsurf coupon at Walgreens Pharmacy
$24704.14
$ 24,701
$3 off with signupwith signup
Lonsurf coupon at Publix Pharmacy
$ 24,850
Lonsurf coupon at Walmart Neighborhood Market Pharmacy
$25280.62
$ 25,278
$3 off with signupwith signup
$25280.62
$ 25,278
$3 off with signupwith signup
$25424.54
$ 25,422
$3 off with signupwith signup

About SingleCare Pricing

SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.

Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.

Prices updated: 04/19/2026

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About Lonsurf

Lonsurf is a brand-name combination prescription drug used to treat colon, rectal, or stomach cancers that have spread to other parts of the body and not responded adequately to other drugs. One of the active ingredients in Lonsurf, trifluridine, works by blocking the cancer cell's ability to grow by corrupting its genetic information. The other active ingredient, tipiracil, slows down the body's breakdown of trifluridine so it has a better chance of working against the cancer cells. The cost of Lonsurf is normally $27,787.56 at full price. A SingleCare Lonsurf coupon reduces that price to $23,543.96 for every 80, 20-8.19mg tablets. You can find more information in our FAQs below.

About Lonsurf

Lonsurf is a brand-name combination prescription drug used to treat colon, rectal, or stomach cancers that have spread to other parts of the body and not responded adequately to other drugs. One of the active ingredients in Lonsurf, trifluridine, works by blocking the cancer cell's ability to grow by corrupting its genetic information. The other active ingredient, tipiracil, slows down the body's breakdown of trifluridine so it has a better chance of working against the cancer cells. The cost of Lonsurf is normally $27,787.56 at full price. A SingleCare Lonsurf coupon reduces that price to $23,543.96 for every 80, 20-8.19mg tablets. You can find more information in our FAQs below.

Lonsurf FAQs

How much does Lonsurf cost without insurance?

Lonsurf costs $27,787.56, but only $23,543.96 using a SingleCare savings card. SingleCare is welcomed nationwide at major pharmacies, such as Kroger, Fry's, Harris Teeter, Walgreens, and many others.

How much does Lonsurf cost with insurance?

Depending on your insurance plan, copay costs for Lonsurf can vary dramatically and could be high. Ask your pharmacist to compare your Lonsurf insurance copay to your price using a SingleCare Lonsurf coupon, which you can get for free right here. With SingleCare, Lonsurf costs only $23,543.96, which may be less than what you pay with insurance.

Does Medicare cover Lonsurf and how much does it cost?

Medicare prescription drug plans usually provide coverage for Lonsurf, but the copay could be high. If you don't have coverage for Lonsurf or if your copay is very high, a SingleCare Lonsurf coupon is a reliable way to save money. With SingleCare, the price of Lonsurf is $23,543.96 for 80, 20-8.19mg tablets.

Is there a generic of Lonsurf?

Lonsurf is a brand-name prescription drug with the active ingredients, trifluridine, and tipiracil. Generic Lonsurf is not available at this time.

What is Lonsurf?

Lonsurf is a brand-name combination prescription drug used to treat colon, rectal, or stomach cancer that has spread to other parts of the body and has not responded adequately to other drugs.

One of the active ingredients in Lonsurf, trifluridine, corrupts the genetic information in cancer cells, blocking their ability to produce new cancer cells. The other active ingredient, tipiracil, slows down the body's breakdown of trifluridine and so allows it more time to work against cancer cells.

Lonsurf is taken as a tablet twice a day with food on a 28-day cycle. Lonsurf is initially taken for five days followed by two days not taking the medication. The cycle is repeated once, followed by a two-week break.

What are the side effects of Lonsurf?

Common side effects of Lonsurf include, but are not limited to, nausea, vomiting, diarrhea, abdominal pain, decreased appetite, weakness, fever, hair loss, runny nose, and changes in taste.

Serious side effects include anemia and low to severely low white blood cell counts, which could put the patient at risk for potentially serious infections.

Allergic reactions are rare. Watch for important signs of an allergic reaction, such as fever, sore throat, swelling, itching, or rash, and talk to your doctor if you suspect an allergic reaction.

Where are Lonsurf coupons from SingleCare accepted?

SingleCare is accepted at most national pharmacies and grocers, including the following:

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