What is Loxapine Succinate: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Loxapine Succinate overview

BRAND NAMES:

Generic Names:

  • Loxapine Succinate

Uses:

  • Treats schizophrenia and symptoms of mental disorders.

Therapeutic Classes:

  • Antipsychotic

Forms:

  • Capsule, Liquid, Tablet

How it’s taken:

  • By mouth

What is Loxapine Succinate used for?

What form(s) does Loxapine Succinate come in

  • Capsule

  • Liquid

  • Tablet

What are common Loxapine Succinate doses?

  • Capsule 5MG

  • Capsule 10MG

  • Capsule 25MG

  • Capsule 50MG

Common Loxapine Succinate prescriptions

  • Loxapine Succinate
    10mg capsule

  • Loxapine Succinate
    25mg capsule

  • Loxapine Succinate
    50mg capsule

  • Loxapine Succinate
    5mg capsule

How to take Loxapine Succinate

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • Oral liquid: Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup. Mix the medicine with orange juice or grapefruit juice before drinking.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Oral liquid: Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup. Mix the medicine with orange juice or grapefruit juice before drinking.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

What to do if you miss a dose of Loxapine Succinate

  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Loxapine Succinate contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to loxapine or similar medicines.

Loxapine Succinate warnings

  • This medicine should not be used to treat dementia in elderly adults because of an increased risk for stroke and other side effects.

  • This medicine may make you dizzy or drowsy, or may cause trouble with thinking or controlling body movements, which may lead to falls, fractures, or other injuries. Do not drive or do anything that could be dangerous until you know how this medicine affects you. You may also feel lightheaded when suddenly getting up from a lying or sitting position, so stand up slowly.

  • Tell your doctor if you are pregnant or breastfeeding, or if you have liver disease, heart or blood vessel disease, blood or bone marrow problems, glaucoma, trouble urinating, bowel blockage, brain tumor, or a history of seizures or breast cancer.

  • This medicine may cause the following problems:Tardive dyskinesia (a muscle disorder that could become permanent)Neuroleptic malignant syndrome (a nerve disorder that could be life-threatening)Changes in vision, eye problemsIncreased levels of prolactin hormone

  • This medicine lowers the number of white blood cells. This weakens your immune system, so you may get infections more easily. Wash your hands often. Avoid people who are sick.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Loxapine Succinate interactions

  • Some medicines can affect how loxapine works. Tell your doctor if you are using lorazepam.

  • Do not drink alcohol while you are using this medicine.

  • Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol.

  • This medicine could cause side effects that include muscle spasms, twitching in your face or body, and uncontrolled tongue or jaw movement. Talk to your doctor about this risk.

Loxapine Succinate side effects

Serious Side Effects

  • Anxiety, irritability, nervousness, restlessness, trouble sleeping

  • Blurred vision

  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes

  • Fast, slow, pounding, or uneven heartbeat

  • Fever, chills, cough, sore throat, body aches

  • Lightheadedness, dizziness, fainting

  • Unusual bleeding, bruising, weakness

  • Twitching or muscle movements you cannot control, problems with balance or walking

  • Sweating, confusion, muscle stiffness

  • Unusual tiredness or sleepiness

Less Serious Side Effects

  • Constipation.

  • Dry mouth, loss of appetite, nausea.

  • Constipation, dry mouth

  • Headache

  • Headache.