Learn more about lyllana
Lyllana costs $210.30 per 1, 1 box (8 twice weekly patches), 0.05mg/24 hr box without insurance. Use the SingleCare Lyllana coupon to pay as little as $43.88 for 1, 1 box (8 twice weekly patches), 0.05mg/24 hr box of Lyllana.
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$46.88
$ 43.88
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$60.44
$ 57.44
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$ 63.99
$70.85
$ 67.85
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$73.02
$ 70.02
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$73.02
$ 70.02
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$76.08
$ 73.08
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$ 79.12
About SingleCare Pricing
SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.
Prices updated: 12/19/2025
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About Lyllana
Lyllana costs $210.30 per 1, 1 box (8 twice weekly patches), 0.05mg/24 hr box without insurance. Use the SingleCare Lyllana coupon to pay as little as $43.88 for 1, 1 box (8 twice weekly patches), 0.05mg/24 hr box of Lyllana.
Learn more about lyllana
Lyllana Price History & Information
Price History for Lyllana (Trademark Generic) & Estradiol (Generic)
1 count, box, 1 box (8 twice weekly patches), 0.05mg/24 hrOur price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
Average 1-Month Prices for Lyllana (Trademark Generic) & Estradiol (Generic)
1 count, box, 1 box (8 twice weekly patches), 0.05mg/24 hr| Pharmacy | Lyllana Retail Price | Estradiol Retail Price | Estradiol SingleCare Price |
|---|---|---|---|
| CVS Pharmacy | $142.00 | $106.72 | $72.80 |
| Walmart | $58.24 | $58.47 | $52.70 |
| Walgreens | $58.80 | $52.26 | $44.96 |
| Kroger Pharmacy | $172.00 | $113.45 | $73.04 |
| Albertsons Pharmacy | $195.68 | $136.12 | $58.56 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
About Lyllana
Lyllana costs $210.30 per 1, 1 box (8 twice weekly patches), 0.05mg/24 hr box without insurance. Use the SingleCare Lyllana coupon to pay as little as $43.88 for 1, 1 box (8 twice weekly patches), 0.05mg/24 hr box of Lyllana.
Where are Lyllana coupons from SingleCare accepted?
SingleCare is accepted at most national pharmacies and grocers, including the following:
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