What is Nateglinide: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Nateglinide overview

BRAND NAMES:

  • Starlix

Generic Names:

  • Nateglinide

Uses:

  • Treats type 2 diabetes.

Therapeutic Classes:

  • Hypoglycemic

Forms:

  • Tablet

How it’s taken:

  • By mouth

What is Nateglinide used for?

Starlix is a meglitinide drug used to treat type 2 diabetes. This medication is combined with proper diet and exercise to help the body to lower high blood sugar. Reducing high blood sugar can prevent conditions such as blindness, kidney damage, nerve problems, loss of limbs, and sexual function problems. Using Starlix may also minimize your risk of heart attack or stroke.

What form(s) does Nateglinide come in

  • Tablet

What are common Nateglinide doses?

  • Tablet 60MG

  • Tablet 120MG

Common Nateglinide prescriptions

  • Nateglinide
    120mg tablet

  • Nateglinide
    60mg tablet

How to take Nateglinide

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • It is best to take this medicine within 30 minutes before a meal. If you skip a meal, then you should also skip your dose of nateglinide.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • It is best to take this medicine within 30 minutes before a meal. If you skip a meal, then you should also skip your dose of nateglinide.

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

What to do if you miss a dose of Nateglinide

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Oral routeAsk your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Nateglinide contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to nateglinide.

Nateglinide warnings

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart or blood vessel disease, adrenal gland problems, or nerve problems.

  • This medicine may cause low blood sugar levels.

  • This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Nateglinide interactions

  • Some foods and medicines can affect how nateglinide works. Tell your doctor if you are using any of the following:Amiodarone, clonidine, fluconazole, guanethidine, glucomannan, Gymnema sylvestre, lanreotide, methandrostenolone, miconazole, octreotide, oxandrolone, phenytoin, reserpine, rifampin, somatropin, sulfinpyrazone, St John's wort, thioctic acid, or voriconazoleBlood pressure medicineA diabetes medicine that you take by mouthA diuretic (water pill)An MAO inhibitorAn NSAID pain or arthritis medicine (including, aspirin, celecoxib, ibuprofen, naproxen)Steroid medicineThyroid medicine

  • Do not drink alcohol while you are using this medicine.

  • Do not drink alcohol while you are using this medicine.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments. You will also need to check your blood sugar on a regular basis at home.

Nateglinide side effects

Serious Side Effects

  • Stuffy or runny nose, cough, sneezing, or sore throat.

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Shaking, trembling, sweating, fast or pounding heartbeat, faintness or lightheadedness, hunger, confusion

  • Rapid weight gain.

  • Swelling in your hands, ankles, or feet.

Less Serious Side Effects

  • Stuffy or runny nose, cough, sneezing, or sore throat.

  • Dizziness or drowsiness

  • Weight gain

  • Dizziness.

  • Rash or itching skin.

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