What is Neomycin-Polymyxin B-Dexamethasone: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Neomycin-Polymyxin B-Dexamethasone overview

BRAND NAMES:

  • Maxitrol, Maxitrol, Dexasporin, Maxitrol

Generic Names:

  • Neomycin-Polymyxin-Dexameth

Uses:

  • Treats and prevents eye infection and inflammation. This medicine contains a corticosteroid.

Therapeutic Classes:

  • Aminoglycoside/Corticosteroid Combination

Forms:

  • Ointment, Drop

How it’s taken:

  • Into the eye

What is Neomycin-Polymyxin B-Dexamethasone used for?

Neomycin/polymyxin/dexamethasone is a medication used to treat eye inflammation and eye infections. The drug contains three components: neomycin and polymyxin (antibiotics) and dexamethasone (steroid). Neomycin/polymyxin/dexamethasone is a generic medication also sold under the brand names Maxitrol, Neo-poly-dex, and Methedex. The individual components of in neomycin/polymyxin/dexamethasone have been available for years. In the treatment of eye inflammation and infection, neomycin/polymyxin/dexamethasone use is common.

What form(s) does Neomycin-Polymyxin B-Dexamethasone come in

  • Ointment

  • Drop

What are common Neomycin-Polymyxin B-Dexamethasone doses?

  • Bottle 5ML of 3.5-10000-0.1

  • Tube 3.5GM of 3.5-10000-0.1

Common Neomycin-Polymyxin B-Dexamethasone prescriptions

  • Neomycin-Polymyxin-Dexameth
    5ml of 3.5-10000-0.1 bottle

  • Neomycin-Polymyxin-Dexameth
    3.5gm of 3.5-10000-0.1 tube of ointment

How to take Neomycin-Polymyxin B-Dexamethasone

  • This medicine may be stored in the refrigerator, in a cool dry place, or at room temperature, away from heat, moisture, and direct light.

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • Ophthalmic routeWash your hands with soap and water before and after using this medicine.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Eye drops: Shake the bottle well just before each use.Lie down or tilt your head back. With your index finger, pull down the lower lid of your eye to form a pocket.Hold the dropper close to your eye with the other hand. Drop the correct number of drops into the pocket made between your lower lid and eyeball. Gently close your eyes.Place your index finger over the inner corner of your eye for 1 minute. Do not rinse or wipe the dropper or allow it to touch anything, including your eye.Keep the bottle upright when you are not using it.

  • Ointment: Lie down or tilt your head back. With your index finger, pull down the lower lid of your eye to form a pocket.Hold the tip of the tube close to your eye with the other hand. Do not touch the tip of the tube with your eye or finger. Squeeze a ribbon of ointment about 1/2 inch long into the pocket between your lower lid and eyeball.Look down. Close your eyes for 1 to 2 minutes.Keep the tube tightly closed when you are not using it.

  • Ophthalmic routeWash your hands with soap and water before and after using this medicine.

  • Eye drops: Shake the bottle well just before each use.Lie down or tilt your head back. With your index finger, pull down the lower lid of your eye to form a pocket.Hold the dropper close to your eye with the other hand. Drop the correct number of drops into the pocket made between your lower lid and eyeball. Gently close your eyes.Place your index finger over the inner corner of your eye for 1 minute. Do not rinse or wipe the dropper or allow it to touch anything, including your eye.Keep the bottle upright when you are not using it.

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • Ointment: Lie down or tilt your head back. With your index finger, pull down the lower lid of your eye to form a pocket.Hold the tip of the tube close to your eye with the other hand. Do not touch the tip of the tube with your eye or finger. Squeeze a ribbon of ointment about 1/2 inch long into the pocket between your lower lid and eyeball.Look down. Close your eyes for 1 to 2 minutes.Keep the tube tightly closed when you are not using it.

  • This medicine may be stored in the refrigerator, in a cool dry place, or at room temperature, away from heat, moisture, and direct light.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

What to do if you miss a dose of Neomycin-Polymyxin B-Dexamethasone

Neomycin-Polymyxin B-Dexamethasone contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to polymyxin B, neomycin, or dexamethasone, or if you have certain other eye infections (including herpes simplex).

Neomycin-Polymyxin B-Dexamethasone warnings

  • Call your doctor if your symptoms do not improve or if they get worse.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Ophthalmic routeIf you hurt your eye, develop an eye infection, or need to have eye surgery, talk with your doctor right away. You may need to change your medicine or stop using it.

  • Tell your doctor if you are pregnant or breastfeeding, or if you have glaucoma, cataracts, or other eye problems (including ulcers in the cornea).

  • This medicine may cause blurred vision. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

  • You will need to have your eyes checked regularly if you use the medicine for 10 days or longer. Be sure to keep all appointments.

Neomycin-Polymyxin B-Dexamethasone interactions

  • Tell your doctor if you are pregnant or breastfeeding, or if you have glaucoma, cataracts, or other eye problems.

  • You will need to have your eyes checked regularly if you use the medicine for 10 days or longer. Keep all appointments.

  • Call your doctor if your symptoms do not improve or if they get worse.

  • Ophthalmic routeIf you hurt your eye, develop an eye infection, or need to have eye surgery, talk with your doctor right away. You may need to change your medicine or stop using it.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Neomycin-Polymyxin B-Dexamethasone side effects

Serious Side Effects

  • Redness, pain, swelling, or itching in the eye

  • Trouble seeing or other vision changes

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

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