What is Ofev? Uses, warnings & side effects

Updated May 14, 2025  •  Published Dec 30, 2020

Ofev overview

BRAND NAMES:

  • Ofev

Generic Names:

  • Ofev

Uses:

  • Treats idiopathic pulmonary fibrosis and systemic sclerosis-associated interstitial lung disease. Also used to treat people with a chronic (long-lasting) interstitial lung disease in which lung fibrosis continues to progress or becomes worse.

Therapeutic Classes:

  • Respiratory Agent

Forms:

  • Capsule

How it’s taken:

  • By mouth

What is Ofev used for?

Ofev is indicated for the treatment of idiopathic pulmonary fibrosis. This condition causes scarring of the lung tissue that results in difficulty breathing. Ofev slows down the progression of this disease but, it is not a cure. It is indicated for use by adults and is available as a capsule.

What form(s) does Ofev come in?

  • Capsule

What are common Ofev dosages?

  • Capsule 100MG

  • Capsule 150MG

Ofev images - What does Ofev look like?

  • Ofev
    100mg capsule

  • Ofev
    150mg capsule

How to take Ofev

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Oral routeIt is best to take this medicine with food or milk.

  • Swallow the capsule whole with water or another liquid. Do not crush, break, or chew it, because it has a bitter taste.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Missed dose: Skip the missed dose and go back to your regular dosing schedule. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Oral routeIt is best to take this medicine with food or milk.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Swallow the capsule whole with water or another liquid. Do not crush, break, or chew it, because it has a bitter taste.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Missed dose: Skip the missed dose and go back to your regular dosing schedule. Do not take extra medicine to make up for a missed dose.

What to do if you miss a dose of Ofev

Ofev contraindications - Who shouldn't take Ofev?

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to nintedanib, or if you are pregnant.

Ofev warnings

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant. You may need to have a negative pregnancy test before starting this medicine. Use an effective form of birth control during treatment and for at least 3 months after the last dose.

  • Tell your doctor if you are breastfeeding, or if you have liver disease, bleeding problems, or heart or blood vessel disease. Tell your doctor if you have stomach or digestion problems or have had recent surgery in your abdomen.

  • This medicine may cause the following problems:Liver problemsStomach or bowel problems (including diarrhea, nausea, vomiting)Increased risk of bleeding, heart attack, or strokeIncreased risk of a tear (perforation) in your digestive system

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Unusual bleeding or bruising

Ofev interactions & what to avoid when taking Ofev

  • Some medicines can affect how nintedanib works. Tell your doctor if you are using the following:Carbamazepine, erythromycin, ketoconazole, phenytoin, rifampicin, St John's wortBlood thinner (including aspirin, warfarin)NSAID pain medicine (including diclofenac, ibuprofen, naproxen)Steroid medicine

  • Do not smoke while you are being treated with this medicine, because this will cause the medicine to not work as well.

  • This medicine may cause the following problems:Liver problemsIncreased risk of bleeding, heart attack, or strokeIncreased risk of a tear (perforation) in your digestive system

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Ofev side effects - How does Ofev make you feel?

Serious Side Effects

  • Severe diarrhea, nausea, vomiting, stomach pain

  • Chest pain that may spread to your arms, jaw, back, or neck, trouble breathing, unusual sweating, faintness

  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes

  • Unusual bleeding or bruising

  • Numbness or weakness on one side of your body, sudden or severe headache, problems with vision, speech, or walking

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

Less Serious Side Effects

  • Dizziness

  • Headache, back pain

  • Tiredness

  • Weight loss or loss of appetite

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