Ondansetron is a generic prescription drug used to prevent nausea and vomiting from chemotherapy, radiation, or surgery. It is part of a class of drugs called serotonin (5-HT3) receptor antagonists that work by blocking the actions of serotonin, a natural chemical that can cause nausea and vomiting. The average retail price of Ondansetron is $412.98 for 30, 4mg tablets, but you could pay only $14.00 for 30, 4mg tablets with a SingleCare coupon for Ondansetron.
Edit your dosage
4.4 cup, 5ml of 4mg/5mlEdit
Unlock members-only prices.Free signup.
You have 0.00 in available bonus savings. Bonus savings will be automatically applied to your next eligible prescription fill.
Show this free card to your pharmacist.

Save an extra $3 on any eligible prescription! Sign up for free
Members can save even more
and it's free to join
SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.
Prices updated: 12/05/2025
Members save the most
Ondansetron is a generic prescription drug used to prevent nausea and vomiting from chemotherapy, radiation, or surgery. It is part of a class of drugs called serotonin (5-HT3) receptor antagonists that work by blocking the actions of serotonin, a natural chemical that can cause nausea and vomiting. The average retail price of Ondansetron is $412.98 for 30, 4mg tablets, but you could pay only $14.00 for 30, 4mg tablets with a SingleCare coupon for Ondansetron.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Ondansetron Hcl Retail Price | Ondansetron Hcl SingleCare Price |
|---|---|---|
| CVS Pharmacy | $118.24 | $74.71 |
| Walmart | $105.90 | $38.10 |
| Walgreens | $123.82 | $119.81 |
| Kroger Pharmacy | $117.22 | $24.98 |
| Albertsons Pharmacy | $122.10 | $117.60 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Ondansetron is a generic prescription drug used to prevent nausea and vomiting from chemotherapy, radiation, or surgery. It is part of a class of drugs called serotonin (5-HT3) receptor antagonists that work by blocking the actions of serotonin, a natural chemical that can cause nausea and vomiting. The average retail price of Ondansetron is $412.98 for 30, 4mg tablets, but you could pay only $14.00 for 30, 4mg tablets with a SingleCare coupon for Ondansetron.
The generic of Ondansetron costs $14.00 for 30, 4mg tablets with a free Ondansetron coupon from SingleCare. However, you could reduce this cost more depending on your prescription information. Use the dropdown menu above to update your Rx details (i.e., brand/generic, form, dosage, quantity) to find the most accurate price of Ondansetron with SingleCare at your local pharmacies.
The average retail cost of Ondansetron without health insurance is $412.98 for 30, 4mg tablets. However, the price can vary depending on different factors, such as the quantity and strength prescribed. For people without insurance, Ondansetron can be expensive. You could save on the price of Ondansetron by using a SingleCare Ondansetron coupon without insurance, which could lower the price to $14.00 for 30, 4mg tablets.
Most insurance plans cover Ondansetron, although the copay amount depends on your insurance plan and its formulary. There may also be quantity limitations of what the insurance plan will cover each month. Check with your insurance company or pharmacy to find out if your plan will cover Ondansetron. If your insurance plan does not cover Ondansetron, you can use a SingleCare prescription coupon to get a discounted price at participating pharmacies.
Medicare Part D and Medicare Advantage plans may cover Ondansetron. Copay and coinsurance amounts vary depending on the level of insurance coverage you have. Check with your plan or speak to your pharmacy to see if your plan covers Ondansetron and what the total cost will be. For people without Medicare coverage, a SingleCare coupon could help reduce the retail Ondansetron price. The current lowest price with SingleCare is $14.00 for 30, 4mg tablets.
Medicaid usually covers the cost of Ondansetron, depending on the plan and state. If Ondansetron is not covered, consider using a SingleCare coupon to pay as little as $14.00 for 30, 4mg tablets.
Ondansetron is known by the brand name Zofran, which is manufactured by Novartis.
If Ondansetron is still too expensive, use a free SingleCare savings card to pay as little as $14.00 for 30, 4mg tablets. Signing up for SingleCare’s loyalty program can help you save even more each month.
There are other potential ways to save on Ondansetron, such as:
Asking your healthcare provider for free samples, although this is not a long-term solution to reduce savings
Shopping around to see the cost of Ondansetron at different pharmacies
Applying for Medicare Extra Help if eligible
Using a flexible spending account (FSA) or health savings account (HSA) if available
Switching to an alternative medication
Cheaper alternatives to Ondansetron may be available based on your insurance’s formulary. Your plan may prefer switching to the regular or orally-disintegrating tablets (ODT) of Ondansetron. Alternative medications to prevent nausea and vomiting include Phenergan (promethazine) and Compazine (prochlorperazine). Discuss all available options with your healthcare provider to determine the best treatment plan for you.
You can use SingleCare coupons at most national pharmacies and grocery stores, including Walgreens, Kroger, Walmart, CVS, Safeway, and more. Just text, email, print, or save your free Ondansetron coupon to your digital wallet and show your pharmacist when you pick up your prescription.
Josephine Bawab, Pharm.D., graduated from Virginia Commonwealth University School of Pharmacy. She began working in community pharmacy in 2012 and has worked for multiple chain pharmacies since then. She is passionate about helping patients and precepting students. She currently works and resides in Virginia, where she is just a few minutes away from the beach.
...SingleCare is accepted at most national pharmacies and grocers, including the following:
Health education, drug info, wellness & more
Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
© 2025 SingleCare Administrators. All rights reserved
© 2025 SingleCare Administrators. All rights reserved