Ondansetron Hcl is a generic prescription drug used to prevent nausea and vomiting from chemotherapy, radiation, or surgery. It is part of a class of drugs called serotonin (5-HT3) receptor antagonists that work by blocking the actions of serotonin, a natural chemical that can cause nausea and vomiting. The average retail price of Ondansetron Hcl is $161.56 for 10, 4mg tablet disintegratings, but you could pay only $5.11 for 10, 4mg tablet disintegratings with a SingleCare prescription discount card.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
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Prices updated: 12/05/2025
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Ondansetron Hcl is a generic prescription drug used to prevent nausea and vomiting from chemotherapy, radiation, or surgery. It is part of a class of drugs called serotonin (5-HT3) receptor antagonists that work by blocking the actions of serotonin, a natural chemical that can cause nausea and vomiting. The average retail price of Ondansetron Hcl is $161.56 for 10, 4mg tablet disintegratings, but you could pay only $5.11 for 10, 4mg tablet disintegratings with a SingleCare prescription discount card.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Ondansetron Retail Price | Ondansetron SingleCare Price |
|---|---|---|
| CVS Pharmacy | $69.16 | $49.69 |
| Walmart | $46.30 | $14.10 |
| Walgreens | $72.77 | $69.18 |
| Kroger Pharmacy | $59.11 | $5.83 |
| Albertsons Pharmacy | $82.20 | $17.70 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Ondansetron Hcl is a generic prescription drug used to prevent nausea and vomiting from chemotherapy, radiation, or surgery. It is part of a class of drugs called serotonin (5-HT3) receptor antagonists that work by blocking the actions of serotonin, a natural chemical that can cause nausea and vomiting. The average retail price of Ondansetron Hcl is $161.56 for 10, 4mg tablet disintegratings, but you could pay only $5.11 for 10, 4mg tablet disintegratings with a SingleCare prescription discount card.
The average retail cost of Ondansetron Hcl without health insurance is $161.56 for 10, 4mg tablet disintegratings. However, the price can vary depending on different factors, such as the quantity and strength prescribed. For people without insurance, Ondansetron Hcl can be expensive. You could save on the cash price of Ondansetron Hcl by using a SingleCare Ondansetron Hcl coupon, which could lower the price to $5.11 for 10, 4mg tablet disintegratings.
Most insurance plans cover Ondansetron Hcl, although the copay amount will depend on your insurance plan and its formulary. Check with your insurance company or pharmacist to find out if your plan will cover Ondansetron Hcl. If your insurance plan does not cover Ondansetron Hcl, you can use a SingleCare prescription coupon to get a discounted price at participating pharmacies.
Medicare Part D and Medicare Advantage plans may cover Ondansetron Hcl. Copay and coinsurance amounts will vary depending on the level of insurance coverage you have. Check with your plan or speak to your pharmacist to see if your plan covers Ondansetron Hcl and what the total cost will be. For people without Medicare coverage, a SingleCare discount card could help reduce the retail price. The current lowest price with SingleCare is $5.11 for 10, 4mg tablet disintegratings.
Ondansetron Hcl is known by the brand name Zofran, which is manufactured by Novartis.
Ondansetron Hcl is a serotonin receptor antagonist used to prevent nausea and vomiting in patients undergoing chemotherapy, radiation, or surgery. Also known as an antiemetic, Ondansetron Hcl blocks the actions of serotonin, which stimulates the part of the brain that controls nausea.
Ondansetron Hcl is available as an orally disintegrating tablet in strengths of 4 mg and 8 mg. It is usually administered before and after chemotherapy or radiation. Ondansetron Hcl orally-disintegrating tablets are placed on top of the tongue and allowed to dissolve. It is not necessary to administer Ondansetron Hcl with a liquid.
The most common side effects of Ondansetron Hcl are headache, constipation, diarrhea, fatigue, and a general feeling of being unwell (malaise). Ondansetron Hcl may also cause dizziness, a fast heartbeat, and itching, among other side effects. Consult your healthcare provider if side effects persist or worsen.
Serious side effects of Ondansetron Hcl include an irregular heart rhythm (cardiac arrhythmia) and allergic reactions. Consult your healthcare provider if you experience a change in heart rate, lightheadedness, or fainting. Seek immediate medical attention if you experience signs or symptoms of an allergic reaction, including fever, rash, and trouble breathing.
Ask your doctor or healthcare provider for medical advice and more information about possible side effects, drug interactions, warnings, and precautions before taking Ondansetron Hcl. Tell your healthcare provider if you have other medical conditions, such as heart problems and liver disease, or take other medications, such as prescription drugs and over-the-counter medicines.
The timing of when to take Ondansetron may vary depending on what it’s being used for. It is usually taken 30 minutes before chemotherapy and then every eight to twelve hours after completing chemotherapy. For radiation therapy, Ondansetron Hcl is usually taken one to two hours before a session and then every eight hours after completion. Ondansetron Hcl is usually taken one hour before starting anesthesia for a procedure. It’s important to consult a healthcare provider for the appropriate instructions on when to take Ondansetron Hcl.
Gerardo Sison, Pharm.D., graduated from the University of Florida. He has worked in both community and hospital settings, providing drug information and medication therapy management services. As a medical writer, he hopes to educate and empower patients to better manage their health and navigate their treatment plans.
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Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved