What is Osphena: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 31, 2020

Osphena overview

BRAND NAMES:

  • Osphena

Generic Names:

  • Osphena

Uses:

  • Treats pain during sex and vaginal dryness caused by vaginal changes during menopause.

Therapeutic Classes:

  • Endocrine-Metabolic Agent

Forms:

  • Tablet

How it’s taken:

  • By mouth

What is Osphena used for?

What form(s) does Osphena come in

  • Tablet

What are common Osphena doses?

  • Tablet 60MG

Common Osphena prescriptions

  • Osphena
    60mg tablet

How to take Osphena

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Oral routeIt is best to take this medicine with food or milk.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Oral routeIt is best to take this medicine with food or milk.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

What to do if you miss a dose of Osphena

Osphena contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to ospemifene, or if you are pregnant. Do not use it if you have vaginal bleeding that has not been checked by a doctor or a history of blood clots, stroke, or heart attack.

Osphena warnings

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Pregnancy after menopause is not likely, but if you think you could be pregnant, tell your doctor. This medicine could harm an unborn baby.

  • Tell your doctor if you are breastfeeding, or if you have liver disease, diabetes, heart disease, high blood pressure, high cholesterol, lupus, or a history of cancer. Tell your doctor if you smoke.

  • This medicine may cause the following problems:Increased risk of heart attack, stroke, or blood clotsIncreased risk of endometrial cancer

  • Tell any doctor who treats you that you are using this medicine. Because of the risk of blood clots, you may need to stop using this medicine before you have surgery or if you need to stay in bed for a long time.

Osphena interactions

  • Some medicines can affect how ospemifene works. Tell your doctor if you are using any of the following:Fluconazole, ketoconazole, rifampinMedicine that contains estrogen

  • Tell your doctor if you are breastfeeding, or if you have liver disease, diabetes, heart disease, high blood pressure, high cholesterol, lupus, or a history of cancer. Tell your doctor if you smoke.

  • This medicine may cause the following problems:Increased risk of heart attack, stroke, or blood clotsIncreased risk of endometrial cancer

  • Tell any doctor who treats you that you are using this medicine. Because of the risk of blood clots, you may need to stop using this medicine before you have surgery or if you need to stay in bed for a long time.

  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Osphena side effects

Serious Side Effects

  • Chest pain that may spread, trouble breathing, coughing up blood, nausea, unusual sweating, faintness

  • Unusual vaginal bleeding, pain or pressure in the pelvis

  • Numbness or weakness in your arm or leg, or on one side of your body, pain in your lower leg (calf), sudden or severe headache, problems with vision, speech, or walking

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

Less Serious Side Effects

  • Warmth or redness in your face, neck, arms, or upper chest

  • White or brownish vaginal discharge

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