What is Oxycodone-Aspirin: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Oxycodone-Aspirin overview

BRAND NAMES:

  • Percodan

Generic Names:

  • Oxycodone-Aspirin

Uses:

  • Treats moderate to severe pain. This medicine contains a narcotic pain reliever and an NSAID.

Therapeutic Classes:

  • Analgesic Combination, Opioid/Salicylate, Aspirin Combination

Forms:

  • Tablet

How it’s taken:

  • By mouth

What is Oxycodone-Aspirin used for?

Oxycodone-Aspirin is a combination medication that is used to treat severe or moderate pain. When taken, this drug reduces the substances released by the receptors responsible for causing inflammation and pain symptoms. Oxycodone-Aspirin is a NSAID prescription only medication that should only be used when a patient is experiencing serious pain.

What form(s) does Oxycodone-Aspirin come in

  • Tablet

What are common Oxycodone-Aspirin doses?

  • Tablet 4.8355-325MG

Common Oxycodone-Aspirin prescriptions

  • oxyCODONE-Aspirin
    4.8355-325mg tablet

How to take Oxycodone-Aspirin

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Store the medicine in a safe and secure place. Drop off any unused narcotic medicine at a drug take-back location right away. If you do not have a drug take-back location near you, flush any unused narcotic medicine down the toilet. Check your local drug store and clinics for take-back locations. You can also check the DEA web site for locations. Here is the link to the FDA safe disposal of medicines website: www.fda.gov/drugs/resourcesforyou/consumers/buyingusingmedicinesafely/ensuringsafeuseofmedicine/safedisposalofmedicines/ucm186187.htm

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • An overdose can be dangerous. Follow directions carefully so you do not get too much medicine at one time.

  • Drink plenty of liquids to help avoid constipation.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Drink plenty of liquids to help avoid constipation.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Store the medicine in a safe and secure place. Drop off any unused narcotic medicine at a drug take-back location right away. If you do not have a drug take-back location near you, flush any unused narcotic medicine down the toilet. Check your local drug store and clinics for take-back locations. You can also check the DEA web site for locations. Here is the link to the FDA safe disposal of medicines website: www.fda.gov/drugs/resourcesforyou/consumers/buyingusingmedicinesafely/ensuringsafeuseofmedicine/safedisposalofmedicines/ucm186187.htm

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • An overdose can be dangerous. Follow directions carefully so you do not get too much medicine at one time.

What to do if you miss a dose of Oxycodone-Aspirin

Oxycodone-Aspirin contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction (including asthma) to oxycodone or aspirin, or if you have stomach or bowel blockage (including paralytic ileus) or hemophilia.

Oxycodone-Aspirin warnings

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, anemia, blood clotting problems, lung disease or breathing problems (including sleep apnea), circulation problems, stomach ulcers, Addison disease, enlarge prostate, trouble urinating, thyroid problems, or a history of head injury, seizures, pancreatitis, alcohol abuse or drug addiction.

  • This medicine might cause the following problems:High risk of overdose, which can lead to deathRespiratory depression (serious breathing problem that can be life-threatening)Sleep-related breathing problems (including sleep apnea, sleep-related hypoxemia)Kidney damageLiver damageSerotonin syndrome (when used with certain medicines)

  • Do not give aspirin to a child or teenager who has chickenpox or flu symptoms, unless approved by a doctor. Aspirin can cause a life-threatening reaction called Reye syndrome.

  • This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.

  • This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.

  • This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Oxycodone-Aspirin interactions

  • Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol. Tell your doctor if you are using buprenorphine, butorphanol, nalbuphine, naltrexone, pentazocine, or a muscle relaxer.

  • Do not drink alcohol while you are using this medicine. Do not take any medicine that contains alcohol.

  • Some medicines can affect how this medicine works. Tell your doctor if you are also using any of the following: Acetazolamide, carbamazepine, cyclobenzaprine, erythromycin, ketoconazole, metaxalone, methotrexate, mirtazapine, phenytoin, probenecid, rifampin, ritonavir, sulfinpyrazone, tramadol, trazodone, or valproic acidBlood pressure medicineBlood thinner (including heparin or warfarin)Diuretic (water pill)Insulin or other diabetes medicineMedicine for depression, anxiety, or mental health problemsNSAID pain or arthritis medicine (including celecoxib, diclofenac, ibuprofen, ketorolac, naproxen)Phenothiazine medicineTriptan medicine for migraine headaches

  • This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

  • Too much of this medicine can cause death. Symptoms of an overdose include extreme slow heartbeat, seizure, and cold, clammy skin.

  • This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.

  • This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone. An overdose in a child could cause death.

Oxycodone-Aspirin side effects

Serious Side Effects

  • Blue lips, fingernails, or skin

  • Extreme weakness, shallow breathing, slow heartbeat, sweating, cold or clammy skin

  • Unusual bleeding, bruising, or weakness

  • Dark urine or pale stools, nausea, vomiting, loss of appetite, yellow skin or eyes

  • Blistering, peeling, red skin rash

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Anxiety, restlessness, fast heartbeat, fever, sweating, muscle spasms, twitching, diarrhea, seeing or hearing things that are not there

  • Severe stomach pain, vomiting blood, bloody or black, tarry stools

  • Change in how much or how often you urinate

  • Lightheadedness, dizziness, fainting

Less Serious Side Effects

  • Sleepiness

  • Constipation, heartburn

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