What is Penicillin G Sodium: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Penicillin G Sodium overview

BRAND NAMES:

Generic Names:

  • Penicillin G Sodium

Uses:

  • Treats infections caused by bacteria. This medicine is a penicillin antibiotic.

Therapeutic Classes:

  • Antibiotic

Forms:

  • Injectable

How it’s taken:

  • By injection

What is Penicillin G Sodium used for?

What form(s) does Penicillin G Sodium come in

  • Injectable

What are common Penicillin G Sodium doses?

  • Solution Reconstituted 5000000UNIT

Common Penicillin G Sodium prescriptions

  • Penicillin G Sodium
    5,000,000 units per vial vial

How to take Penicillin G Sodium

  • Injection routeA nurse or other health provider will give you this medicine.

  • Take all of the medicine in your prescription to clear up your infection, even if you feel better after the first few doses.

  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given through a needle placed in one of your veins or as a shot into one of your muscles.

  • Injection routeA nurse or other health provider will give you this medicine.

  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given through a needle placed in one of your veins or as a shot into one of your muscles.

  • Take all of the medicine in your prescription to clear up your infection, even if you feel better after the first few doses.

What to do if you miss a dose of Penicillin G Sodium

  • You must use this medicine on a fixed schedule. Call your doctor or pharmacist if you miss a dose.

  • Injection routeAsk your pharmacist, doctor, or health caregiver about the best way to dispose of any leftover medicine, containers, and other supplies. Throw away old medicine after the expiration date has passed.

  • Injection routeThrow away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Penicillin G Sodium contraindications

  • You should not use this medicine if you have had an allergic reaction to penicillin G sodium or any penicillin antibiotic such as amoxicillin, amoxicillin/clavulanate, Amoxil®, Augmentin®, Trimox®, or Veetids®.

Penicillin G Sodium warnings

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have asthma, a history of allergies, kidney disease, or heart disease.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • Call your doctor if your symptoms do not improve or if they get worse.

  • Lightheadedness or fainting.

  • Numbness or tingling in your hands, feet, or lips.

  • Rapid weight gain, swelling in your hands, ankles, or feet.

  • Seizures.

  • Shortness of breath, cold sweat, and bluish-colored skin.

  • Unusual bleeding, bruising, or weakness.

  • Yellowing of your skin or the whites of your eyes.

Penicillin G Sodium interactions

  • Make sure your doctor knows if you are using other antibiotic medicines (such as chloramphenicol, erythromycin, doxycycline, minocycline, tetracycline, trimethoprim/sulfamethoxazole, Bactrim®, Chloromycetin®, Chloroptic®, Cotrim®, E.E.S.®, E-Mycin®, Ery-tab®, or Septra®) or a diuretic or "water pill" (such as ethacrynic acid, furosemide, hydrochlorothiazide, Edecrin®, Esidrix®, HydroDiuril®, Lasix®, Microzide®, or Oretic®).

  • Tell your doctor if you are also using aspirin (Ecotrin®), indomethacin (Indocin®), phenylbutazone, or probenecid (Benemid®).

  • This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • Call your doctor if your symptoms do not improve or if they get worse.

Penicillin G Sodium side effects

Serious Side Effects

  • Unusual bleeding, bruising, or weakness.

  • Fever, chills, cough, sore throat, and body aches.

  • Rapid weight gain, swelling in your hands, ankles, or feet.

  • Numbness or tingling in your hands, feet, or lips.

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Change in how much or how often you urinate.

  • Confusion, irregular heartbeat.

  • Diarrhea that may contain blood.

  • Shortness of breath, cold sweat, and bluish-colored skin.

  • Lightheadedness or fainting.

  • Seizures.

  • Yellowing of your skin or the whites of your eyes.

Less Serious Side Effects

  • Pain, itching, burning, swelling, or a lump under your skin where the needle is placed.

  • Muscle or joint pain.

  • Mild skin rash, itching, or redness.

  • Stomach pain.

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