What is Pentacel: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Pentacel overview

BRAND NAMES:

  • Quadracel, Kinrix, Pentacel, Pentacel-DTaP/IPV Component, Pentacel

Generic Names:

  • Pentacel

Uses:

  • Protects against infections caused by diphtheria, tetanus (lockjaw), pertussis (whooping cough), polio, and Haemophilus influenzae type b., Protects against infections caused by diphtheria, tetanus (lockjaw), pertussis (whooping cough), and polio.

Therapeutic Classes:

  • Vaccine

Forms:

  • Injectable, Injectable, Injectable

How it’s taken:

  • By injection, By injection

What is Pentacel used for?

What form(s) does Pentacel come in

  • Injectable

  • Injectable

  • Injectable

What are common Pentacel doses?

  • Suspension Reconstituted

Common Pentacel prescriptions

  • Pentacel
    5 vials suspension reconstituted

How to take Pentacel

  • A nurse or other health professional will give your child this vaccine. This vaccine is given as a shot into a muscle, usually in the shoulder.

  • Your child may receive other vaccines at the same time as this one. You should receive other information sheets on those vaccines. Make sure you understand all the information given to you.

  • Your child may also receive medicines to help prevent or treat some minor side effects of the vaccine.

  • Missed dose: If this vaccine is part of a series of vaccines, it is important that your child receive all of the shots. Try to keep all scheduled appointments. If your child must miss a shot, make another appointment as soon as possible.

  • Your child may receive other vaccines at the same time as this one. You should receive other information sheets on those vaccines. Make sure you understand all the information given to you.

  • Your child may also receive medicines to help prevent or treat some minor side effects of the vaccine.

  • Missed dose: If this vaccine is part of a series of vaccines, it is important that your child receive all of the shots. Try to keep all scheduled appointments. If your child must miss a shot, make another appointment as soon as possible.

  • A nurse or other health professional will give your child this vaccine. This vaccine is given as a shot into a muscle, usually in the shoulder.

  • A nurse or other trained health professional will give your child this vaccine. The vaccine is given as a shot into one of your child's muscles. Your child will receive a series of 4 shots.

  • Your child may receive other vaccines at the same time as this one. You should receive patient information sheets about all of the vaccines. Make sure you understand all of the information that is given to you.

  • Your child may also receive medicines to help prevent or treat some minor side effects of the vaccine, such as fever and soreness.

  • Your child may receive other vaccines at the same time as this one. You should receive patient information sheets about all of the vaccines. Make sure you understand all of the information that is given to you.

  • A nurse or other trained health professional will give your child this vaccine. The vaccine is given as a shot into one of your child's muscles. Your child will receive a series of 4 shots.

  • Your child may also receive medicines to help prevent or treat some minor side effects of the vaccine, such as fever and soreness.

What to do if you miss a dose of Pentacel

  • If this vaccine is part of a series of vaccines, it is important that your child receive all of the shots. Try to keep all scheduled appointments. If your child must miss a shot, make another appointment with the doctor as soon as possible.

Pentacel contraindications

  • This vaccine may not be right for everyone. Your child should not receive this vaccine if he or she had an allergic or other serious reaction to tetanus, diphtheria, pertussis, or polio vaccine or to neomycin or polymyxin B. Tell the doctor if your child has seizures or other nervous system problems.

  • This vaccine should not be given to a child who has had an allergic reaction to the separate or combined diphtheria, tetanus, pertussis, polio, or Haemophilus b vaccines. This vaccine should not be given to a child who has had seizures, mood or mental changes, or lost consciousness within 7 days after receiving a pertussis vaccine. This vaccine should not be given to a child who has brain problems or seizures that are not controlled.

Pentacel warnings

  • Make sure your child's doctor knows if your child has been sick or had a fever recently. Tell your doctor about all other vaccines your child has had. Tell your doctor about any reaction your child has had after receiving any type of vaccine. This includes fainting, seizures, a fever over 105 degrees F, crying that would not stop, or severe redness or swelling where the shot was given. Tell your doctor if your child has had Guillain-Barré syndrome after a tetanus vaccine.

  • Make sure your doctor knows if your child was born prematurely. This vaccine may cause breathing problems in infants born prematurely.

  • This vaccine will not treat an active infection. If your child has an infection due to diphtheria, tetanus, pertussis, polio, or Haemophilus influenzae type b, your child will need medicines to treat these infections.

  • Crying constantly for 3 hours or more

  • Fever over 105 degrees F

  • Lightheadedness or fainting

  • Seizures

  • Severe muscle weakness, sleepiness, or drowsiness

  • Tell the doctor if your child has a bleeding disorder, or a history of Guillain-Barré syndrome or other severe reaction to a vaccine (including fever or prolonged crying).

  • This vaccine may cause the following problems:Guillain-Barré syndrome

  • Tell the doctor if your child is allergic to latex rubber or has been sick or had a fever recently.

  • Lightheadedness or fainting

  • Seizures

  • Severe headache

  • Severe muscle weakness or numbness

Pentacel interactions

  • Some foods and medicines can affect how this vaccine works. Tell the doctor if your child has recently received any of the following:Immune globulinBlood thinner (including warfarin)Any treatment that weakens the immune system, such as cancer medicine, radiation treatment, or a steroid

  • This vaccine may cause the following problems:Guillain-Barré syndrome

  • Tell the doctor if your child is allergic to latex rubber or has been sick or had a fever recently.

  • Make sure your doctor knows if your child was born prematurely. This vaccine may cause breathing problems in infants born prematurely.

  • This vaccine will not treat an active infection. If your child has an infection due to diphtheria, tetanus, pertussis, polio, or Haemophilus influenzae type b, your child will need medicines to treat these infections.

  • Make sure your doctor knows if your child uses a medicine that weakens the immune system, such as a steroid (such as hydrocortisone, methylprednisolone, prednisolone, prednisone), radiation treatment, or cancer medicine. This vaccine may not work as well if your child has a weak immune system.

Pentacel side effects

Serious Side Effects

  • Lightheadedness or fainting

  • Seizures

  • Crying constantly for 3 hours or more

  • Severe headache

  • Fever over 105 degrees F

  • Severe muscle weakness or numbness

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Crying constantly for 3 hours or more

  • Seizures

  • Fever over 105 degrees F

  • Severe muscle weakness, sleepiness, or drowsiness

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Bluish lips, skin, or nails

  • Chills, cough, sore throat, body aches

  • Lightheadedness or fainting

Less Serious Side Effects

  • Mild pain, redness, swelling, tenderness, or a lump where the shot was given

  • Tiredness

  • Fussiness or irritability

  • Mild pain, redness, or swelling where the shot was given

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