What is Prialt? Uses, warnings & side effects

Updated May 14, 2025  •  Published Dec 30, 2020

Prialt overview

BRAND NAMES:

  • Prialt

Generic Names:

  • Prialt

Uses:

  • Relieves severe chronic pain.

Therapeutic Classes:

  • Analgesic

Forms:

  • Injectable

How it’s taken:

  • Into the fluid around your spinal cord and brain

What is Prialt used for?

What form(s) does Prialt come in?

  • Injectable

What are common Prialt dosages?

  • Vial 1ML of 100MCG/ML

Prialt images - What does Prialt look like?

  • Prialt
    1ml of 100mcg/ml vial

  • Prialt
    20ml of 500mcg/20ml vial

How to take Prialt

  • A doctor or other trained health professional will give you this medicine in a hospital. This medicine is given through a needle or catheter into your back using a special infusion pump.

  • A doctor or other trained health professional will give you this medicine in a hospital. This medicine is given through a needle or catheter into your back using a special infusion pump.

What to do if you miss a dose of Prialt

Prialt contraindications - Who shouldn't take Prialt?

  • You should not receive this medicine if you have had an allergic reaction to ziconotide. You should not receive this medicine if you have an infection at the injection site, blockage in your spine, uncontrolled bleeding problems, or a history of psychosis (mental illness). Your doctor will decide if there is any reason you should not receive this medicine.

Prialt warnings

  • Unusual thoughts or behavior, or thoughts of killing oneself or others.

  • Seizures or tremors.

  • Uncontrolled eye movements.

  • Seeing, hearing, or feeling things that are not there.

  • Problems with speech, balance, or walking.

  • Numbness, tingling, or burning pain in your hands, arms, legs, or feet.

  • Muscle pain, soreness, or weakness.

  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments. Blood tests may be needed to check for unwanted effects.

  • Call your doctor right away if you have unexplained muscle pain or weakness, loss of strength or energy, and with or without darkened urine. Your doctor may need to reduce the dose of your medicine.

  • If you or your caregiver notice any signs of meningitis such as confusion, drowsiness, fever, headache, nausea or vomiting, seizures, or stiff neck, call your doctor right away.

  • Serious infection or meningitis can occur if the catheter of this medicine becomes disconnected. It is very important that you or your caregiver must follow doctor's instructions about the care of the catheter and the use of the infusion pump.

  • This medicine may make you dizzy, drowsy, confused, disoriented, or clumsy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.

  • This medicine may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. If you or your caregiver notice any of these adverse effects, tell your doctor right away.

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, depression, or mental illness.

Prialt interactions & what to avoid when taking Prialt

  • Make sure your doctor knows if you are also using medicines to treat depression (such as amitriptyline, doxepin, nortriptyline, Celexa®, Pamelor®, Prozac®, Serzone®, Sinequan®, or Zoloft®), sleeping medicine (such as alprazolam, diazepam, midazolam, Halcion®, Librium®, Valium®, Versed®, or Xanax®), medicines for seizures (such as phenytoin, primidone, Dilantin®, or Tegretol®), or a phenothiazine medicine (such as prochlorperazine, Compazine®, Mellaril®, Phenergan®, Thorazine®, or Trilafon®).

  • Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol.

  • Do not drink alcohol while you are using this medicine.

  • Serious infection or meningitis can occur if the catheter of this medicine becomes disconnected. It is very important that you or your caregiver must follow doctor's instructions about the care of the catheter and the use of the infusion pump.

  • If you or your caregiver notice any signs of meningitis such as confusion, drowsiness, fever, headache, nausea or vomiting, seizures, or stiff neck, call your doctor right away.

  • Call your doctor right away if you have unexplained muscle pain or weakness, loss of strength or energy, and with or without darkened urine. Your doctor may need to reduce the dose of your medicine.

  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments. Blood tests may be needed to check for unwanted effects.

Prialt side effects - How does Prialt make you feel?

Serious Side Effects

  • Unusual thoughts or behavior, or thoughts of killing oneself or others.

  • Decrease in how much or how often you urinate, or painful urination.

  • Muscle pain, soreness, or weakness.

  • Problems with speech, balance, or walking.

  • Numbness, tingling, or burning pain in your hands, arms, legs, or feet.

  • Lightheadedness or fainting.

  • Fever, headache, nausea or vomiting, seizures, or stiff neck.

  • Feeling unusually cold.

  • Seeing, hearing, or feeling things that are not there.

  • Dark-colored urine.

  • Confusion, depression, restlessness, or changes in mood or behavior.

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Uncontrolled eye movements.

  • Seizures or tremors.

Less Serious Side Effects

  • Blurred vision.

  • Rash or itching skin.

  • Dry skin.

  • Abnormal thinking, anxiety, or memory loss or being forgetful.

  • Dizziness or headache.

  • Trouble sleeping.

  • Pain, swelling, itching, or burning where the catheter is placed.

  • Sleepiness or unusual drowsiness.

  • Lack or loss of strength.

  • Diarrhea or loss of appetite.

  • Sensation of spinning.

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